Journals / Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi / 2020 / Cilt: 25 - Sayı: 2

Epidemiology, Risk Factors and Mortality of Candidemia: Case-control Study

Kandidemi Epidemiyolojisi, Risk Faktörleri ve Mortalitesi: Olgu-kontrol Çalışması

Pages
206–212
Publication Date
2022-10-17
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Prior antibiotic use [Odds Ratio (OR)= 15.52; 95% confidence interval (CI) 6.025-39.99; p< 0.0001], durationof hospitalization (OR= 1.043; 95% CI 1.007-1.08; p= 0.019), and total parenteral nutrition (OR= 1.181; 95% CI 1.032-1.353;p= 0.016) were found to be independent risk factors for candidemia.Conclusion: A better understanding of the risk factors for candidemia among hospitalized patients may have significant implicationsfor prevention.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Candida species are important nosocomial bloodstream infections that cause high mortality rates and prolonged hospitalization.In this study, we aimed to determine risk factors for candidemia and the distribution of Candida species causing bloodstreaminfections.Materials and Methods: The study was conducted as case-control study at an 810-bed tertiary care teaching hospital between April2014 and April 2017.Results: A total of 75 candidemia episodes were identified during the study period.
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Key Findings & Data:Candida albicans was the most-frequent species(68%), followed by Candida glabrata (9.3%), and Candida tropicalis (6.7%).
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Conclusion & Impact:Prior antibiotic use [Odds Ratio (OR)= 15.52; 95% confidence interval (CI) 6.025-39.99; p< 0.0001], durationof hospitalization (OR= 1.043; 95% CI 1.007-1.08; p= 0.019), and total parenteral nutrition (OR= 1.181; 95% CI 1.032-1.353;p= 0.016) were found to be independent risk factors for candidemia.Conclusion: A better understanding of the risk factors for candidemia among hospitalized patients may have significant implicationsfor prevention.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: Candida species are important nosocomial bloodstream infections that cause high mortality rates and prolonged hospitalization.In this study, we aimed to determine risk factors for candidemia and the distribution of Candida species causing bloodstreaminfections.Materials and Methods: The study was conducted as case-control study at an 810-bed tertiary care teaching hospital between April2014 and April 2017.Results: A total of 75 candidemia episodes were identified during the study period. Candida albicans was the most-frequent species(68%), followed by Candida glabrata (9.3%), and Candida tropicalis (6.7%). The rate of candidemia was higher in intensive care unitsthan in other units. Prior antibiotic use [Odds Ratio (OR)= 15.52; 95% confidence interval (CI) 6.025-39.99; p< 0.0001], durationof hospitalization (OR= 1.043; 95% CI 1.007-1.08; p= 0.019), and total parenteral nutrition (OR= 1.181; 95% CI 1.032-1.353;p= 0.016) were found to be independent risk factors for candidemia.Conclusion: A better understanding of the risk factors for candidemia among hospitalized patients may have significant implicationsfor prevention.

Özet

Giriş: Kandidaların etken olduğu kan dolaşımı infeksiyonları, yüksek mortalite oranları ve hastane yatış sürelerini uzatmaları açısından önemli nozokomiyal infeksiyonlar arasındadır. Bu çalışmada, üçüncü basamak sağlık hizmeti veren bir üniversite hastanesinde kandidemi risk faktörlerini ve etken olan kandida türlerinin saptanması amaçlanmıştır. Materyal ve Metod: Çalışma 810 yataklı üçüncü basamak bir üniversite hastanesinde Nisan 2014-Nisan 2017 tarihleri arasında olgu-kontrol çalışması olarak yürütüldü. Bulgular: Çalışma süresi boyunca toplam 75 kandidemi olgusu değerlendirilmiştir. En sık kandidemi etkeni Candida albicans (%68) olarak bulunmuştur. Candida glabrata (%9.3) ve Candida tropicalis (%6.7) diğer sık etkenler olarak tespit edilmiştir. Yoğun bakım ünitelerinde kandidemi sıklığı diğer ünitelerden daha fazla bulunmuştur. Daha önceden antibiyotik kullanımı [Odds Ratio (OR)= 15.52; %95 güven aralığı (GA) 6.025-39.99; p< 0.0001] ve total parenteral nütrisyon (OR= 1.181; %95 GA 1.032-1.353; p= 0.016) kandidemi için bağımsız risk faktörleri olarak bulunmuştur. Sonuç: Kandidemi risk faktörlerinin iyi anlaşılması hastanede uzun süreli yatan hastalarda bu infeksiyonların önlenmesi için önemlidir.

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Cite This Article

ERGİN, Ç., ÖZDEMİR, K., KOCAOĞLU, C., KUTLU, S. S., KUTLU, M. (2022). Epidemiology, Risk Factors and Mortality of Candidemia: Case-control Study. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Cilt: 25 - Sayı: 2, 206–212. https://ajindex.com/articles/517111

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