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Journals / Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi / 2016 / Cilt: 30 - Sayı: 1

Reelin Gene RS7341475 Polymorphism is Associated with Migraine with Aura

Reelin Gen rs7341475 Polimorfizmi Auralı Migrenle İlişkilidir

Kürşat KARGÜN
Bilge KARA
Ayşe SÖZEN
Ebru MARZİOĞLU ÖZDEMİR
Murat KARA
Gökhan ÖZDEMİR
Pages
9–14
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There was a significant correlation between nausea and rs12705169 (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: In this study, the association between Reeline and migraine disease was investigated through analyzing reelin gene polymorphism in patients with migraine with aura.
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Key Findings & Data:Reelin gene localized on chromosome 7 synthesizes an extracellular matrix protein which plays a role in central nervous system development.
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Conclusion & Impact:There was a significant correlation between nausea and rs12705169 (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: In this study, the association between Reeline and migraine disease was investigated through analyzing reelin gene polymorphism in patients with migraine with aura. Migraine is the most common vascular headache in which genetic and environmental components are acting and which leads to loss of labor force. Reelin gene localized on chromosome 7 synthesizes an extracellular matrix protein which plays a role in central nervous system development. Any mutations or altered expressions in reelin gene are known to precipitate neuropsychiatric diseases. Methods: Ninety-one patients diagnosed with migraine and 85 healthy controls were included in the study. DNA was obtained in blood samples and rs7341475, rs362691, rs12705169 polymorphisms were studied with RT-PCR using TaqMan probes. Results: rs7341475 polymorphism and A allele detected in migraine patients were statistically significant when compared with control group. There was a significant correlation between nausea and rs12705169 (P

Özet

Amaç: Bu çalışmada auralı migren hastalarında Reelin gen polimorfizmleri incelenerek, Reelin gen ile migren hastalığı arasındaki ilişki araştırıldı. Migren vasküler baş ağrıları içinde en sık görülen, genetik ve çevresel komponentlerin etkili olduğu ve işgücü kaybına yol açan bir hastalıktır. İnsanlarda 7. kromozomda lokalize olan Reelin geni, santral sinir sisteminin gelişiminde önemli bir rol oynayan ekstraselüler bir matriks proteinini sentezler. Reelin genindeki herhangi bir mutasyon ya da ekspresyon değişikliklerinin nöropsikiyatrik hastalıklara zemin hazırladığı bilinmektedir. Gereç ve Yöntem: Bu çalışmaya migren tanısı almış 91 hasta ve 85 sağlıklı kontrol grubu alındı. Kişilerden alınan kanlardan DNA elde edildi ve rs7341475, rs362691, rs12705169 polimorfizmleri TaqMan probları kullanılarak RT-PCR ile çalışıldı. Bulgular: Migren hastalarında tespit edilen rs7341475 polimorfizmi ve A alleli kontrol grubu ile karşılaştırıldığında istatiksel olarak anlamlı bulundu (P

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Cite This Article

KARGÜN, K., KARA, B., SÖZEN, A., ÖZDEMİR, E. M., KARA, M., ÖZDEMİR, G. (2022). Reelin Gene RS7341475 Polymorphism is Associated with Migraine with Aura. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, Cilt: 30 - Sayı: 1, 9–14. https://ajindex.com/articles/514569

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