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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2015 / Cilt: 23 - Sayı: 4

Koroner arter hastalarında adiponektin ve leptin polimorfizmleri

Adiponectin and leptin polymorphisms in patients with coronary artery disease

Kürşat KARGÜN
Sefa ŞENOL
Mustafa YILDIZ
Murat KARA
Hayrettin TEKÜMİT
Pages
637–642
Publication Date
2022-09-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our study results showed that gene polymorphismof adiponectin at rs2241766 decreased the risk of CAD,while gene polymorphism of leptin receptor rs1137101 andrs7799039 increased the risk.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: In this study, adiponectin and leptin genepolymorphism were analyzed in patients with planned coronaryartery bypass graft (CABG) surgeries.
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Key Findings & Data:Methods: Between January 2012 and April 2013, 110 patients inthe study group (78 males, 32 females; mean age 61.3±7.8 years;range 47 to 76 years) were scheduled for CABG surgery forcoronary artery disease (CAD) and 96 healthy subjects withoutCAD in the control group (68 males, 28 females; mean age59.4±8.3 years; range 46 to 78 years) were included in the study.
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Conclusion & Impact:Conclusion: Our study results showed that gene polymorphismof adiponectin at rs2241766 decreased the risk of CAD,while gene polymorphism of leptin receptor rs1137101 andrs7799039 increased the risk.
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Background: In this study, adiponectin and leptin genepolymorphism were analyzed in patients with planned coronaryartery bypass graft (CABG) surgeries. Methods: Between January 2012 and April 2013, 110 patients inthe study group (78 males, 32 females; mean age 61.3±7.8 years;range 47 to 76 years) were scheduled for CABG surgery forcoronary artery disease (CAD) and 96 healthy subjects withoutCAD in the control group (68 males, 28 females; mean age59.4±8.3 years; range 46 to 78 years) were included in the study. Results: Adiponectin rs2241766 gene polymorphism and allelefrequency were statistically significantly lower in the studygroup (p 0.05). Gene polymorphisms of adiponectin at rs1501299 andtheir allele frequencies were similar between the study and thecontrol groups (p>0.05). Conclusion: Our study results showed that gene polymorphismof adiponectin at rs2241766 decreased the risk of CAD,while gene polymorphism of leptin receptor rs1137101 andrs7799039 increased the risk. By demonstrating the biochemicalconsequences of adiponectin and leptin polymorphisms, thisstudy may, together with larger and more comprehensive studies,serve as a reference concerning these risks associated with thesepolymorphisms and the benefits of prophylaxis in CAD.

Özet

Amaç: Bu çalışmada, koroner arter baypas greft (KABG)cerrahisi yapılacak hastalarda adiponektin ve leptin genpolimorfizmleri analiz edildi. Ça­lış­ma­pla­nı:­ Ocak 2012 - Nisan 2013 tarihleri arasındaçalışma grubunda koroner arter hastalığı (KAH) nedeniyleKABG yapılması planlanan toplam 110 hasta (78 erkek, 32 kadın;ort. yaş 61.3±7.8 yıl; dağılım 47-76 yıl) ve kontrol grubundaKAH olmayan 96 sağlıklı birey (68 erkek, 28 kadın; ort. yaş59.4±8.3 yıl; dağılım 46-78 yıl) çalışmaya dahil edildi. Bul gu lar: Adiponektin rs2241766 gen polimorfizmi ve allelgörülme sıklığı, çalışma grubunda istatistiksel olarak anlamlıdüzeyde daha düşüktü (p 0.05). Adiponektikrs1501299 gen polimorfizmleri ve allel görülme sıklıkları,çalışma ve kontrol grupları arasında benzerdi (p>0.05). So nuç: Çalışma bulgularımız, adiponektin rs2241766 genpolimorfizminin KAH riskini azalttığını, ancak leptinreseptörü rs1137101 ve rs7799039 gen polimorfizminin riskiartırdığını gösterdi. Adiponektin ve leptin polimorfizmlerininbiyokimya sonuçlarını gösteren bu çalışma, daha geniş ölçeklive daha kapsamlı çalışmalar ile birlikte, bu polimorfizmlerebağlı riskler ve KAHta profilaksinin yararına ilişkin birreferans olabilir.

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Cite This Article

KARGÜN, K., ŞENOL, S., YILDIZ, M., KARA, M., TEKÜMİT, H. (2022). Koroner arter hastalarında adiponektin ve leptin polimorfizmleri. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 23 - Sayı: 4, 637–642. https://ajindex.com/articles/424193

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