Journals / European Journal of Therapeutics / 2017 / Cilt: 23 - Sayı: 2

90-90-90 targets: Reaching the first 90 diagnosing exposed babies using the virologic HIV DNA nucleic acid-based technique

90-90-90 hedefleri: Virolojik HIV DNA nükleik asit bazlı teknik kullanarak enfekte olan bebeklerin yüzde 90 teşhis edilmesi

Pages
55–59
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, the feat of mother-to-baby HIV transmission elimination achieved by Cuba, Armenia, Belarus, and Thailand is achievable in Nigeria through provision of universal access to health care.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The HIV pandemic has continued to be a huge challenge in Nigeria, with the problem of stigmatization reducing the chances of early determination of HIV status in pregnant women, which may increase the chances of transmission to the child from the mother.
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Key Findings & Data:Methods: This was a study of HIV-exposed infants conducted between January 2013 and December 2015.
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Conclusion & Impact:However, the feat of mother-to-baby HIV transmission elimination achieved by Cuba, Armenia, Belarus, and Thailand is achievable in Nigeria through provision of universal access to health care.
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The HIV pandemic has continued to be a huge challenge in Nigeria, with the problem of stigmatization reducing the chances of early determination of HIV status in pregnant women, which may increase the chances of transmission to the child from the mother. Our study was designed to determine the trend as well as diagnosis of HIV infection in exposed infants. It will also determine among infants the factors associated with the transmission of the infection from their mothers. Methods: This was a study of HIV-exposed infants conducted between January 2013 and December 2015. The study population was HIV-exposed infants. Dried blood spots (DBS) were analyzed using the polymerase chain reaction technique. Results: Only 18.3%, 20.1%, and 14.2% of the babies had their DBS samples taken at six weeks of age in 2013, 2014, and 2015, respectively. The percentage of positives across the three years was 3.6%, 3.2%, and 3.1%, as the majority of the babies took single-dose nevirapine and had exclusive breastfeeding, but only 1.5% and 1.3% of the babies within 18-month PMTCT retested for 2013 and 2014 were confirmed positive after cessation of all exposures. Conclusion: ART administration to both HIV-infected mothers and their babies has demonstrated an effective mechanism of the PMTCT program, as this is evident in the low positivity outcome. However, the feat of mother-to-baby HIV transmission elimination achieved by Cuba, Armenia, Belarus, and Thailand is achievable in Nigeria through provision of universal access to health care.

Özet

Amaç: HIV salgını, hamilelerde erken tespit şansını azaltan ve anneden çocuğa geçme olasılığını artırabilecek damgalama ile birlikte, Nijerya'da büyük bir problem olmaya devam etmektedir. Çalışmamız etkilenen bebeklerde HIV enfeksiyonunun tanısının yanı sıra eğilimi belirlemek amacıyla dizayn edilmiştir. Ayrıca, çocuklarda annelerden enfeksiyon geçişi ile ilişkili faktörler de çalışmada tespit edilecektir. Yöntemler: Bu çalışma Ocak 2013 ve Aralık 2015 tarihleri arasında HIV'den etkilenen çocuklarla yapıldı. Çalışma popülasyonunu HIV'e maruz kalan çocuklar oluşturdu. Kuru kan lekeleri (DBS) polimeraz zincir reaksiyonu tekniği kullanılarak analiz edildi. Bulgular: Bebeklerin sadece %18,3, %20,1 ve %14,2'sinin ilk altı haftalarında kuru kan lekesi örnekleri sırasıyla 2013, 2014 ve 2015 yıllarında alındı. Üç yıldaki pozitiflik yüzdesi %3,6, %3,2 ve %3,1 olarak bulunan bebeklerin çoğunluğu tek doz nevirapin alıyordu ve sadece anne sütü ile besleniyordu. Ancak, 18 ayda PMTCT (prevention of mother-to-child transmission: anneden çocuğa HIV geçişinin önlenmesi) kapsamında 2013 ve 2014 yıllarında tekrar test edilen bebeklerin sadece %1,5 ve %1,3'ü tüm risk maruziyetlerin kesilmesi sonrasında pozitif olarak bulundu. Sonuç: HIV-enfekte annelerde ve bebeklerinde ART (antiretroviral therapy) uygulaması PMTCT programının etkili bir mekanizmasını göstermiştir ve bu da düşük pozitiflik sonucunda belirgindir. Ancak, Küba, Ermenistan, Belarus ve Tayland tarafından gerçekleştirilen anneden bebeğe HIV geçişinin önlenmesi başarısı evrensel sağlık bakımına erişim şartıyla Nijerya'da mümkündür.

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Cite This Article

USMAN, S. O., AGBOOLA, G. B., UMEOZULU, F. C. (2022). 90-90-90 targets: Reaching the first 90 diagnosing exposed babies using the virologic HIV DNA nucleic acid-based technique. European Journal of Therapeutics, Cilt: 23 - Sayı: 2, 55–59. https://ajindex.com/articles/512362

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