SavedAdd your journal

Journals / European Journal of Therapeutics / 2019 / Cilt: 25 - Sayı: 4

Comparison of Pulmonary Artery Catheter and Central Venous Catheter for Early Goal Directed Targeted Therapy in Sepsis and Septic Shock

Gülseren ELAY
Kürşat GÜNDOĞAN
Muhammet GÜVEN
Ramazan COŞKUN
Murat SUNGUR
Pages
253–258
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the early resuscitation period, it was found that in the CVC-directed therapy group, the urine output and the mean arterial blood pressure were higher, but vasoconstrictor need was lower (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of the present study was to compare the effect of the pulmonary artery catheterization (PAC) method and the central venous catheterization (CVC) method on hemodynamic and inflammatory parameters in early goal-directed therapy (EGDT).Methods: This was a randomized prospective study.
📊
Key Findings & Data:Patients with sepsis and septic shock within 12 h of diagnosis were included in the study.
💡
Conclusion & Impact:In the early resuscitation period, it was found that in the CVC-directed therapy group, the urine output and the mean arterial blood pressure were higher, but vasoconstrictor need was lower (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of the present study was to compare the effect of the pulmonary artery catheterization (PAC) method and the central venous catheterization (CVC) method on hemodynamic and inflammatory parameters in early goal-directed therapy (EGDT).Methods: This was a randomized prospective study. Patients with sepsis and septic shock within 12 h of diagnosis were included in the study. Each group received strict protocolized resuscitation for 72 h.Results: The mean age of the patients was 63.4±14.5 years. The study included 15 (52%) male and 14 (48%) female patients. The length of stay in the hospital and the duration of mechanical ventilation were similar between the two groups. The length of stay in the intensive care unit was shorter in the CVC group (p=0.025). High mobility group box 1 levels were lower at 72 h in the CVC group (p=0.026). In the early resuscitation period, it was found that in the CVC-directed therapy group, the urine output and the mean arterial blood pressure were higher, but vasoconstrictor need was lower (p

🔖

Cite This Article

ELAY, G., GÜNDOĞAN, K., GÜVEN, M., COŞKUN, R., SUNGUR, M. (2022). Comparison of Pulmonary Artery Catheter and Central Venous Catheter for Early Goal Directed Targeted Therapy in Sepsis and Septic Shock. European Journal of Therapeutics, Cilt: 25 - Sayı: 4, 253–258. https://ajindex.com/articles/512252

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pin-sky MR. Epidemiology of severe sepsis in the United States. Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001
  2. [CrossRef ] 2. El-Samalouti VT, Hamann L, Flad HD, Ulmer AJ. The biology of endo-toxin. Methods Mol Biol 2000
  3. [CrossRef ] 3. Nguyen HB, Corbett SW, Steele R, Banta J, Clark RT, Hayes SR, et al. Implementation of a bundle of quality indicators for the early man-agement of severe sepsis and septic shock is associated with de-creased mortality. Crit Care Med 2007
  4. [CrossRef ] 4. Rady MY, Rivers EP, Nowak RM. Resuscitation of the critically ill in the ED. Responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate. Am J Emerg Med 1996
  5. [CrossRef ] 5. Cortez A, Zito J, Lucas CE, Gerrick SJ. Mechanism of inappropriate polyuria in septic patients. Arch Surg 1977
  6. [CrossRef ] 6. Beal AL, Cerra FB. Multiple organ failure syndrome in the 1990s. Sys-temic inflammatory response and organ dysfunction. JAMA 1994
  7. [CrossRef ] 7. Rajaram SS, Desai NK, Kalra A, Gajera M, Cavanaugh SK, Brampton W, et al. Pulmonary artery catheters for adult patients in intensive care. Cochrane Database Syst Rev 2013
  8. CD003408. [CrossRef ] 8. Seymour CW, Rosengart MR. Septic shock: Advances in diagnosis and treatment. JAMA 2015
  9. [CrossRef ] 9. Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014
  10. [CrossRef ] 10. Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD, et al. Trial of early goal-directed resuscitation for septic shock. N Engl J Med 2015
  11. [CrossRef ]11. Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2014
  12. [CrossRef ] 12. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign: international guidelines for manage-ment of severe sepsis and septic shock: 2008. Crit Care Med 2008
  13. [CrossRef ] 13. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001
  14. [CrossRef ] 14. Boyd O, Grounds RM, Bennett ED. A random