AI Summary & Key Takeaways
AI InsightIn this cohort of patients, westudied the utility of LNR in predicting recurrence and overall survival (OS) after NAC.Materials and Methods: An Institutional cancer registry was queried from 2009 to 2014 for women with axillary node-positive BC with noevidence of distant metastasis, and who received NAC followed by surgery for loco-regional treatment (axillary dissection with breast conservingsurgery or total mastectomy).
📌 3 Key Takeaways
Abstract
Objective: Axillary lymph node status is an important prognostic factor in breast cancer (BC). Residual nodal disease burden after neoadjuvantchemotherapy (NAC) is one of the important prognostic factors to determine the prognosis and in the treatment of BC. Lymph node ratio (LNR)defied as the ratio of the number of positive lymph nodes to total excised axillary lymph nodes, may be a stronger determinant of prognosis thanpN in axillary nodal staging, although there is very limited data evaluating its prognostic value in the setting of NAC. In this cohort of patients, westudied the utility of LNR in predicting recurrence and overall survival (OS) after NAC.Materials and Methods: An Institutional cancer registry was queried from 2009 to 2014 for women with axillary node-positive BC with noevidence of distant metastasis, and who received NAC followed by surgery for loco-regional treatment (axillary dissection with breast conservingsurgery or total mastectomy). Patients with axillary complete response were excluded. Locoregional recurrence (LRR), distant recurrence (DR) andoverall survival (OS) rates were reviewed regarding pN and LNR.Results: A total of 179 patients were analyzed. Median follow up time was 24 [25%, 75%: 13-42] months. Patients with pN1 in comparison topN2 and pN3 had lower rate of LRR (9% vs. 15% and 14%, respectively; p=0.41), lower rate of DR (14% vs. 25% and 27%, respectively, p=0.16)and increased rate of OS (89% vs. 79% and 78%, respectively, p=0.04). In comparison to patients with LNR >20%, patients with LNR ≤20% hadlower LRR (9% vs. 14%, p=0.25), lower DR (13% vs. 27%, p=0.01) and improved OS (89% vs. 79%, p=0.02) rates. In the pN1 group, patientswho had a LNR >20% had higher DR (22% vs. 14%, p=0.48) rates in comparison to patients with LNR ≤20%. In ER/PR (+) patients who hadLNR ≤20% DR was 6% compared with 23% in patient who had LNR >20% (p=0.02), and in triple negative patients’ OS rate was signifiantlybetter compared the LNR less/equal or more than 20% (71% vs 33%, p=0.001).Conclusion: Our study demonstrated that LNR adds valuable information for the prognosis after NAC and this additional information shouldbe considered when deciding further treatment and follow-up for patients who had residual tumor burden on the axilla. Ths observation should betested in a larger study