Journals / Eurasian Journal of Medicine / 2010 / Cilt: 42 - Sayı: 3

Stabil KOAH'lı hastalarda serum prealbümin seviyelerinin hastalığın ağırlığını ve amfizem paternini gösteren parametreler ile ilişkisi

The relationships of serum prealbumin levels with parameters that indicate severity of disease and emphysema pattern in patients with stable chronic obstructive pulmonary disease

Pages
105–110
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Also, in COPD patients with low prealbumin levels, while the FEV1 and FEV1/ FVC% values and the length of the line connecting the costophrenic sinus to the diaphragm dome significantly decreased, the retrosternal distance dramatically increased compared to COPD patients with normal prealbumin levels.Conclusion: Serum prealbumin levels were convenient for monitoring malnutrition in COPD, were correlated with spirometric and anamnestic data indicating the severity of COPD, and were useful in distinguishing the subtype of COPD due to its decrease in the presence of emphysema.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Malnutrition, which is a complication frequently observed in chronic obstructive pulmonary disease (COPD) and negatively affects prognosis, has become a parameter that must be monitored.
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Key Findings & Data:Serum prealbumin levels had a negative correlation with the total number of hospitalizations due to acute exacerbation, total hospitalization time, and average number of annual hospitalizations, whereas it showed a positive correlation with FEV1 and FEV1/FVC% values.
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Conclusion & Impact:Also, in COPD patients with low prealbumin levels, while the FEV1 and FEV1/ FVC% values and the length of the line connecting the costophrenic sinus to the diaphragm dome significantly decreased, the retrosternal distance dramatically increased compared to COPD patients with normal prealbumin levels.Conclusion: Serum prealbumin levels were convenient for monitoring malnutrition in COPD, were correlated with spirometric and anamnestic data indicating the severity of COPD, and were useful in distinguishing the subtype of COPD due to its decrease in the presence of emphysema.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Malnutrition, which is a complication frequently observed in chronic obstructive pulmonary disease (COPD) and negatively affects prognosis, has become a parameter that must be monitored. Even though various methods are applied to assess malnutrition, biochemical parameters, especially serum prealbumin levels, are useful.Materials and Methods: The relationships between serum prealbumin levels, which we used as an indicator of malnutrition, with the severity of disease and the parameters predicting emphysema in stable COPD patients with no additional health problems were determined in this prospective study.Results: One hundred stable COPD patients were evaluated prospectively. Serum prealbumin levels had a negative correlation with the total number of hospitalizations due to acute exacerbation, total hospitalization time, and average number of annual hospitalizations, whereas it showed a positive correlation with FEV1 and FEV1/FVC% values. Serum prealbumin levels were positively correlated with the length of the line connecting the costophrenic sinus to the dome of the diaphragm, which is used to assess the presence of emphysema and was negatively correlated with retrosternal distance. Also, in COPD patients with low prealbumin levels, while the FEV1 and FEV1/ FVC% values and the length of the line connecting the costophrenic sinus to the diaphragm dome significantly decreased, the retrosternal distance dramatically increased compared to COPD patients with normal prealbumin levels.Conclusion: Serum prealbumin levels were convenient for monitoring malnutrition in COPD, were correlated with spirometric and anamnestic data indicating the severity of COPD, and were useful in distinguishing the subtype of COPD due to its decrease in the presence of emphysema.

Özet

Amaç: KOAH'ta sık rastlanan ve prognozu olumsuz etkileyen bir komplikasyon olan malnütrisyon, takibi zorunlu bir parametre halini almıştır. Malnütrisyonu değerlendirmede birçok yöntem kullanılsa da, biyokimyasal parametrelerin özellikle de serum prealbümin düzeyinin oldukça yararlı olduğu gösterilmiştir.Gereç ve Yöntem: Prospektif çalışmamızda malnütrisyon belirteci olarak kullandığımız serum prealbümin düzeyinin, malnütrisyon nedeni olabilecek ek sağlık problem olmayan stabil KOAH'lı hastalarda hastalığın ağırlığı ve amfizemi predikte eden parametrelerle ilişkisi araştırıldı.Bulgular: Yüz stabil KOAH'lı hastanın prospektif olarak değerlendirildiği çalışmada serum prealbümin değerinin KOAH akut alevlenme nedenli toplam yatış sayısı, toplam yatış günü ve ortalama yıllık yatış sayısı ile negatif; %FEV1 ve FEV1/FVC değerleri ile pozitif korelasyon gösterdiği saptandı. Amfizem varlığını değerlendirdiğimiz kostofrenik sinüsleri birleştiren çizginin diyafragma kubbesine uzaklığı ile pozitif, retrosternal mesafe ile negatif korelasyon mevcuttu. Prealbümin değeri normal olan KOAH'lılara oranla düşük olan KOAH'lılarda %FEV1, FEV1/FVC değerleri ve kostofrenik sinüsleri birleştiren çizginin diyafragma kubbesine uzaklığının anlamlı derecede azalmış, retrosternal mesafenin anlamlı derecede artmış olduğu görüldü.Sonuç: Serum prealbümin düzeyinin KOAH'ta malnütrisyon düzeyini takip etmede kullanışlı, KOAH'ta hastalığın ağırlığını gösteren spirometrik ve anamnestik verilerle korele olduğu, amfizem varlığında düzeyinin daha çok azalması nedeniyle KOAH subtipinin ayrımında yardımcı olabileceği sonucuna varıldı.

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Cite This Article

EDİGER, D., EGE, E., UZASLAN, E., GÜNEY, N. A., DOĞANAY, S., GÖÇMEN, H. (2022). Stabil KOAH'lı hastalarda serum prealbümin seviyelerinin hastalığın ağırlığını ve amfizem paternini gösteren parametreler ile ilişkisi. Eurasian Journal of Medicine, Cilt: 42 - Sayı: 3, 105–110. https://ajindex.com/articles/509294

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