Journals / Eurasian Journal of Medicine / 2017 / Cilt: 49 - Sayı: 3

Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus

Plazma Aterojenik İndeks, Sistemik Lupus Eritematozusunda Subklinik Aterosklerozun Bağımsız Bir Göstergedir

Pages
193–197
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Besides, for the control group, the PAI value was −0.09±0.20 and cIMT value was 0.50±0.15 mm (p=0.002, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation.
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Key Findings & Data:The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients.Materials and Methods: We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria.
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Conclusion & Impact:Besides, for the control group, the PAI value was −0.09±0.20 and cIMT value was 0.50±0.15 mm (p=0.002, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients.Materials and Methods: We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria. Furthermore, we selected age- and body mass index (BMI)-matched 56 female healthy individuals. PAI was measured as a logarithmic value of triglyceride to high-density cholesterol ratio. We used carotid intima media thickness (cIMT) as an inflammatory marker because of its widespread use. The lipid and other biochemical parameters of patient and control groups were examined.Results: The PAI and cIMT values of SLE patients were 0.04±0.23 and 0.78±0.18 mm, respectively. Besides, for the control group, the PAI value was −0.09±0.20 and cIMT value was 0.50±0.15 mm (p=0.002, p

Özet

Amaç: Sistemik lupus eritematozus (SLE), kronik inflamasyon ile karakterize bir hastalıktır. Plazma aterojenik indeks (PAI), kardiyovasküler hastalık ve kardiyak risk için değerli bir belirteçtir. Bu çalışmanın amacı PAI'in SLE hastalarında aterosklerozu ve kardiyak riski değerlendirmekteki rolü ve klinik kullanılabilirliliğini araştırmaktır.Gereç ve Yöntem: Amerikan Romatoloji Koleji (1997) tanı kriterlerine göre değerlendirilen 56 kadın SLE hastası dahil edildi. Ayrıca yaş ve vucüt kitle indeksi uyumlu 56 kadın sağlıklı kişi seçildi. PAI, trigliserit'in yüksek yoğunluklu kolesterole oranı logartimik ölçümüdür. Karotis intima medya kalınlığı (KIMK) inflamatuvar belirteç olarak yaygın olarak kullanıldığından, bu işareti bu çalışmada kullandık. Hasta ve kontrol gruplarının lipid ve diğer biyokimyasal parametreleri incelendi.Bulgular: Hasta grubunda PAI 0,04±0,23, KIMK 0,78±0,18 mm, kontrol grubunda PAI -0,09±0,20, KIMK 0,50±0,15 mm olduğu tespit edildi. Hasta grubunda PAI ve KIMK'ın kontrol grubuna kıyasla yüksek olduğu görüldü (sırasıyla p=0,002, p

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Cite This Article

KUCUK, A., CURE, E., ICLİ, A., ARSLAN, S., SAKİZ, D., BAYKARA, R. A., USLU, A. U. (2022). Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus. Eurasian Journal of Medicine, Cilt: 49 - Sayı: 3, 193–197. https://ajindex.com/articles/509032

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References (1)

  1. Kucuk A, Uslu AU, Yilmaz R, Salbas E, Solak Y, Tunc R. Relationship between prevalence and severity of restless legs syndrome and anemia in patients with systemic lupus erythematosus. Int J Rheum Dis 2015; 20: 469-73. [CrossRef] 2. Barutcu A, Aksu F, Ozcelik F, et al. Evaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies. Lupus 2015; 24: 1019-28. [CrossRef] 3. Chaudhari D, Madani M Al, Balbissi Md K Al, Paul TK. Lupus Myocarditis Presenting as Life-threatening Overt Heart Failure: A Case Report with Review of Cardiovascular Manifestations of Systemic Lupus Erythematosus. J La State Med Soc 2015; 167: 220-2. 4. Icli A, Cure E, Cumhur Cure M, et al. Novel myokine: irisin may be an independent predictor for subclinic atherosclerosis in Behçet’s disease. J Investig Med 2016; 64: 875-81. [CrossRef] 5. Batún Garrido JA de J, Radillo Alba HA, Hernández Nú-ez É, Olán F. Dyslipidaemia and atherogenic risk in patients with systemic lupus erythematosus. Med Clin (Barc) 2016; 147: 63-6. [CrossRef] 6. Dobiásová M. AIP--atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice. Vnitr Lek 2006; 52: 64-71. 7. Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, et al. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran 2015; 29: 627-35. 8. Balta S, Aparci M, Ozturk C, Yildirim AO, Demir M, Celik T. Carotid intima media thickness and subclinical early atherosclerosis. Int J Cardiol.2016; 203: 1146. [CrossRef] 9. Kucuk A, Uslu AU, Arslan S, et al. IschemiaModified Albumin and Atherosclerosis in Patients With Familial Mediterranean Fever. Angiology 2016; 67: 456-60. [CrossRef] 10. Uslu AU, Kucuk A, Balta S, et al. The relation between ischemia modified albumin levels and carotid intima media thickness in patients with rheumatoid arthritis. Int J Rheum Dis 2016; 12851. [CrossRef] 11. Icli A, Cure E, Cure MC, et al. Endocan Levels and Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus. Angiology 2015; 67: 749-55. [CrossRef] 12. Feingold KR, Grunfeld C. The Effect of Inflammation and Infection on Lipids and Lipoproteins. In: De Groot LJ, Beck-Peccoz P, Chrousos G, et al., eds. Endotext. South Dartmouth (MA)2000. 13. Khovidhunkit W, Kim M-S, Memon RA, et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 2004; 45: 1169