Journals / İstanbul Kuzey Klinikleri / 2019 / Cilt: 6 - Sayı: 4

Evaluation of serum thiol/disulfide homeostasis in patients with ankylosing spondylitis by a novel method

Pages
348–354
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thiol and disulfide values were measured by thenovel methods.RESULTS: Native thiol (NT) (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVE: Increased reactive oxygen species may play an important role in Ankylosing spondylitis (AS) etiopathogenesis.The thiol group is a very potent antioxidant.
📊
Key Findings & Data:In this study, we aimed to investigate the presence of oxidative stress in patientswith AS by evaluating thiol/disulfide homeostasis.METHODS: In this study, a total of 66 AS patients (27 male, 39 female) and 66 healthy controls (21 male, 45 female) wereenrolled.
💡
Conclusion & Impact:Thiol and disulfide values were measured by thenovel methods.RESULTS: Native thiol (NT) (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Increased reactive oxygen species may play an important role in Ankylosing spondylitis (AS) etiopathogenesis.The thiol group is a very potent antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patientswith AS by evaluating thiol/disulfide homeostasis.METHODS: In this study, a total of 66 AS patients (27 male, 39 female) and 66 healthy controls (21 male, 45 female) wereenrolled. Recently, a novel method for the thiol measurement was found. Thiol and disulfide values were measured by thenovel methods.RESULTS: Native thiol (NT) (p

🔖

Cite This Article

DOĞAN, E., EREL, Ö., ACET, G. K., AYDIN, A., CÜRE, E., KUCUK, A., OMMA, A., TUZCU, A., CÜRE, M. C., BAYKARA, R. A. (2022). Evaluation of serum thiol/disulfide homeostasis in patients with ankylosing spondylitis by a novel method. İstanbul Kuzey Klinikleri, Cilt: 6 - Sayı: 4, 348–354. https://ajindex.com/articles/551450

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A. Ankylosing spondylitis: an overview. Ann Rheum Dis 2002
  2. 8–18. [CrossRef ] 2. Kim TH, Uhm WS, Inman RD. Pathogenesis of ankylosing spondylitis and reactive arthritis. Curr Opin Rheumatol 2005
  3. 17(4):400–5. 3. Marker-Hermann E, Fraundorf E, Zeidler H, Sieper J. Pathogenesis of ankylosing spondylitis -mechanisms of disease manifestation and chronicity. Z. Rheumatol 2004
  4. 187–92. [CrossRef ] 4. Sieper J. Spondyloarthritis. Z. Rheumatol 2004
  5. [CrossRef ] 5. Valente RL, Valente JM, de Castro GR, Zimmermann AF, Fialho SC, Pereira IA. Subclinical atherosclerosis in ankylosing spondylitis: is there a role for inflammation? Rev Bras Reumatol 2013
  6. 377–81. [CrossRef ] 6. Zochling J, Smith EU. Seronegative spondyloarthritis. Best Pract Res Clin Rheumatol 2010
  7. 747–56. [CrossRef ] 7. Stanek A, Cieslar G, Romuk E, Kasperczyk S, Sieron-Stoltny K, Birkner E, et al. Decrease in antioxidant status of plasma and erythrocytes from patients with ankylosing spondylitis. Clin Biochem 2010
  8. 566–70. [CrossRef ] 8. Ozgocmen S, Sogut S, Ardicoglu O, Fadillioglu E, Pekkutucu I, Akyol O. Serum nitric oxide, catalase, superoxide dismutase, and malondialdehyde status in patients with ankylosing spondylitis. Rheumatol Int 2004
  9. 80–3. [CrossRef ] 9. Kundi H, Ates I, Kiziltunc E, Cetin M, Cicekcioglu H, Neselioglu S, et al. A novel oxidative stress marker in acute myocardial infarction
  10. thiol/ disulphide homeostasis. Am J Emerg Med 2015
  11. 1567–71. [CrossRef ] 10. Içme F, Erel Ö, Avci A, Satar S, Gülen M, Acehan S. The relation between oxidative stress parameters, ischemic stroke, and hemorrhagic stroke. Turk J Med Sci 2015
  12. 947–53. [CrossRef ] 11. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014
  13. 326–32. [CrossRef ] 12. Pasaoglu H, Sancak B, Bukan N. Lipid peroxidation and resistance to oxidation in patients with type 2 diabetes mellitus. Tohoku J Exp Med 2004
  14. 211–8. [CrossRef ] 13. Dogru A, Balkarli A, Cetin GY, Neselioglu S, Erel O, Tunc SE, et al. Thiol/disulfide homeostasis in patients with ankylosing spondylitis. Bosn J Basic Med Sci 2016
  15. 187–92. [CrossRef ] 14. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994
  16. 2286–91. 15. Calin A, Garrett S, Whitelock H, Kennedy LG, O’Hea J, Mallorie P,