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Journals / Eurasian Journal of Medicine / 2020 / Cilt: 52 - Sayı: 3

Leucocytes and Th-associated Cytokine Profile of HIV-Leishmaniasis Co-Infected Persons Attending Abuja Teaching Hospital, Nigeria

Idris Nasir ABDULLAHİ
Anthony Uchenna EMERİBE
Hafeez Aderinsayo ADEKOLA
Habiba Yahaya MUHAMMAD
Abdurrahman El-fulaty AHMAD
Abubakar Umar ANKA
Yusuf MOHAMMED
Shamsuddeen HARUNA
Bamidele Soji ODERİNDE
Halima Ali SHUWA
Adamu BABAYO
Pages
271–276
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

There were significantly higher values in basophil (4.4±2.5%) and eosinophil counts (12.9±3.8%) in HIV/leishmania coinfected persons (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: T-helper cells (Th)-1& -2 cytokines homeostasis control or predict clinical outcome of infected persons, especially those with HIV /AIDS.
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Key Findings & Data:This case-control study evaluated the leucocytes differentials, TNF-alpha, interleukin (IL)-2 and -10 levels among HIV infected persons with serological evidence of leishmaniasis attending University of Abuja Teaching Hospital, NigeriaMaterials and Methods: Blood samples from 28 HIV infected persons who had Leishmania donovani rK39 and Immunoglobulin-G (IgG) positive (group 1), 30 age- & -sex matched HIV infected persons without Leishmania antibodies (group 2) and 30 apparently healthy persons without HIV and Leishmania antibodies (group 3).
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Conclusion & Impact:There were significantly higher values in basophil (4.4±2.5%) and eosinophil counts (12.9±3.8%) in HIV/leishmania coinfected persons (p
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: T-helper cells (Th)-1& -2 cytokines homeostasis control or predict clinical outcome of infected persons, especially those with HIV /AIDS. This case-control study evaluated the leucocytes differentials, TNF-alpha, interleukin (IL)-2 and -10 levels among HIV infected persons with serological evidence of leishmaniasis attending University of Abuja Teaching Hospital, NigeriaMaterials and Methods: Blood samples from 28 HIV infected persons who had Leishmania donovani rK39 and Immunoglobulin-G (IgG) positive (group 1), 30 age- & -sex matched HIV infected persons without Leishmania antibodies (group 2) and 30 apparently healthy persons without HIV and Leishmania antibodies (group 3). Full blood counts, TNF alpha, IL-2 and -10 levels were analyzed using automated hematology analyzer and ELISA, respectively. Structured questionnaires were used to collate biodata and clinical presentations of participants.Results: Ten (35.7%) participants in group 1 were on ART, 15 (50%) in group 2 were on ART, while group 3 were ART naïve. There were significantly higher values in basophil (4.4±2.5%) and eosinophil counts (12.9±3.8%) in HIV/leishmania coinfected persons (p

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Cite This Article

ABDULLAHİ, I. N., EMERİBE, A. U., ADEKOLA, H. A., MUHAMMAD, H. Y., AHMAD, A. E., ANKA, A. U., MOHAMMED, Y., HARUNA, S., ODERİNDE, B. S., SHUWA, H. A., BABAYO, A. (2022). Leucocytes and Th-associated Cytokine Profile of HIV-Leishmaniasis Co-Infected Persons Attending Abuja Teaching Hospital, Nigeria. Eurasian Journal of Medicine, Cilt: 52 - Sayı: 3, 271–276. https://ajindex.com/articles/508871

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