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Journals / Eurasian Journal of Medical Investigation / 2019 / Cilt: 3 - Sayı: 1

Evaluation of Visual Evoked Potential and Optical Coherence Tomography Results in Idiopathic Parkinson’s Disease Patients

Sibel ÜSTÜN ÖZEK
Emma JAMOUSSİ
Cihat ÖRKEN
Pages
7–13
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

P100latency can be measured in addition to UPDRS for evaluating the PD’s severity.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study evaluates Visual Evoked Potential (VEP) and Optical Coherence Tomography (OCT) in IdiopathicParkinson’s Disease (PD) Patients; analyzes the relation between the disease’s severity and such values, and investigatesthe presence of interocular asymmetry in patients with one-sided dominance.Methods: 40 eyes of 20 PD patients at various stages were evaluated.
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Key Findings & Data:The disease’s severity was measured via UPDRS(Unified Parkinson’s Disease Rating Scale) and Hoehn&Yahr (H&Y) scales.Results: There were 21 (52%) eyes with a pathological P100 latency.
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Conclusion & Impact:P100latency can be measured in addition to UPDRS for evaluating the PD’s severity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: This study evaluates Visual Evoked Potential (VEP) and Optical Coherence Tomography (OCT) in IdiopathicParkinson’s Disease (PD) Patients; analyzes the relation between the disease’s severity and such values, and investigatesthe presence of interocular asymmetry in patients with one-sided dominance.Methods: 40 eyes of 20 PD patients at various stages were evaluated. The disease’s severity was measured via UPDRS(Unified Parkinson’s Disease Rating Scale) and Hoehn&Yahr (H&Y) scales.Results: There were 21 (52%) eyes with a pathological P100 latency. P100 latency prolonged as the H&Y staging wentup; however, it was not statistically significant. Retinal nerve fiber layer (RNFL) thickness was normal in 70% and retinalthinning was found in 25% of the eyes. The most thinning was observed in the lower and upper quadrant, respectively.Central macular thickness decreased in 62.5% and macular volume decreased in 70% of the eyes. The difference inaverage RNFL thickness was higher in patients with motor involvement on the left (p=0.044).Conclusion: It was observed that P100 latency prolonged in parallel with the progression of the disease stage, andaverage RNFL thickness increased in advanced stages while the central macular thickness and volume decreased. P100latency can be measured in addition to UPDRS for evaluating the PD’s severity.

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Cite This Article

ÖZEK, S. Ü., JAMOUSSİ, E., ÖRKEN, C. (2022). Evaluation of Visual Evoked Potential and Optical Coherence Tomography Results in Idiopathic Parkinson’s Disease Patients. Eurasian Journal of Medical Investigation, Cilt: 3 - Sayı: 1, 7–13. https://ajindex.com/articles/508747

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References (16)

  1. References 1. Archibald NK, Clarke MP, Mosimann UP, Burn DJ. The retina in Parkinson’s disease. Brain 2009
  2. 132(pt 5):1128–45. 2. Ehinger B. Functional role for dopamine in the retina. In: Osborne NN, Chader G, eds. Progress in Retinal Research, Vol 2, Oxford, Pergamon Press, 1983
  3. 213–32. 3. Osborne NN. Indoleamines in the eye with special reference to the serotonergic neurones of the retina. In: Osborne NN, Chader G, eds. Progress in Retinal Research, Vol 3, Oxford, Pergamon Press, 1984
  4. 61–104. 4. Qu XZ, Fertel R, Neff NH, Hadjiconstantinou M. Pharmacological characterization of rat retinal dopamine receptors. J Pharm Exp Ther 1989
  5. 621–25. 5. Alter M, Halpern L, Kurtland LT, et al. Multiple sclerosis in Israel. Arch Neurol 1962
  6. 253–63. 6. Bodis-Wollner I. Retinopathy in Parkinson disease. J Neural Transm 2009
  7. 1493–1501. 7. Bodis-Wollner I. Yahr MD, Mylin L, Thornton J. Dopaminergic deficiency and delayed visual evoked potentials in humans. Ann Neurol 1982
  8. 478–83. 8. Balcı S Y. Muhsin Erslan M, Temel. Glaucoma, Parkinson’s disease and neurodegeneration Marmara Medical Journal 2015
  9. 8–12. 9. La Morgia C, Barboni P, Rizzo G, et al. Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern? Eur J Neurol 2013
  10. 198–201. 10. Kirbas S, Turkyilmaz K, Tufekci A, Durmus M.Retinal nerve fiber layer thickness in Parkinson disease. J Neuroophthalmol 2013
  11. 62–5. 11. Miri S, GlazmanS, Mylin L, Bodis-Wollner I. A combination of retinal morphology and visual electrophysiology testing increases diagnostic yield in Parkinson's disease. ParkinsonismRelat Disord 2016
  12. S134–7. 12. Altintaş O. Işeri P, Özkan B, Çağlar Y. Correlation between retinal morphological and functional findings and clinical severity in Parkinson's disease. Doc Ophthalmol 2008
  13. 137–46. 13. I. Bodis-Wollner, M.D. Yahr, Measurements of visual evoked potentials in Parkinson's disease, Brain 1978
  14. 661–71. 14. Price MJ, Feldman RG, Adelberg D, Kayne H. Abnormalities in color vision and contrast sensitivity in Parkinson’s disease. Neurology 1992
  15. 887–90. 15. Garcia-Martin E. Rodriguez-Mena D, Satue M, Almarcegui C
  16. Dolz I, Alarcia R et al. Electrophysiology and Optical Coherence Tomography to Evaluate Parkinson Disease Severity. Investigative Ophthalmology & Visual Science February 2014, Vol.55, 696–705. 16. Kaur M, Saxena R, Singh D, Behari M, Sharma P, Menon V. Correlation Between Structural and Functional Retinal Changes in Parkinson Disease. J Neuroophth