Journals / Eurasian Journal of Medical Investigation / 2020 / Cilt: 4 - Sayı: 1

Effects of Fenugreek Extract on Total Antioxidant/Oxidant Status at Ehrlich Ascites Tumor Bearing Mice

Pages
116–122
Publication Date
2022-10-12
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

In the end of in vivo studies, while the weight of experimental animals was estimated.Results: It was found that fenugreek extract delaying the weight gain.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: In this study, we aimed to effect of extract that derived from fenugreek on total antioxidant/oxidant statusat Ehrlich ascites tumor bearing Balb/C mice.Methods: The phenolic of Fenugreek extract was calculated as gallic acid equivalent using Folin-Ciocalteu method.Fenugreek extract concentration determined 200–400 mg/kg.
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Key Findings & Data:These effects were higher inthe group receiving fenugreek 400 mg/kg intraperitoneally.Conclusion: As a result, the fenugreek extract shows antioxidant effect on EAT cells.
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Conclusion & Impact:In the end of in vivo studies, while the weight of experimental animals was estimated.Results: It was found that fenugreek extract delaying the weight gain.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: In this study, we aimed to effect of extract that derived from fenugreek on total antioxidant/oxidant statusat Ehrlich ascites tumor bearing Balb/C mice.Methods: The phenolic of Fenugreek extract was calculated as gallic acid equivalent using Folin-Ciocalteu method.Fenugreek extract concentration determined 200–400 mg/kg. In the end of in vivo studies, while the weight of experimental animals was estimated.Results: It was found that fenugreek extract delaying the weight gain. Administered fenugreek extract group hadlower serum TOS and OSI index and had higher serum TAS compared to the control group. These effects were higher inthe group receiving fenugreek 400 mg/kg intraperitoneally.Conclusion: As a result, the fenugreek extract shows antioxidant effect on EAT cells. We believe that our studies will beguiding for new studies about fenugreek and fenugreek could be advised as a food because of its antioxidant effect.Thus, it may have anticancer effect.

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Cite This Article

ALPA, S., YİLMAZ, S., INANÇ, N., NİSARİ, M. (2022). Effects of Fenugreek Extract on Total Antioxidant/Oxidant Status at Ehrlich Ascites Tumor Bearing Mice. Eurasian Journal of Medical Investigation, Cilt: 4 - Sayı: 1, 116–122. https://ajindex.com/articles/508651

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References (13)

  1. Cross CE, HALLIWELL B, BORISH ET, PRYOR WA, AMES BN, SAUL RL, et al. Oxygen radicals and human disease. Ann Intern Med 1987;107:526–45
  2. Asayama K, Nakane T, Uchida N, Hayashibe H, Dobashi K, Nakazawa S. Serum antioxidant status in streptozotocin-induced diabetic rat. Horm Metab Res 1994;26:313–5
  3. Corrocher R, Casaril M, Bellisola G, Gabrielli GB, Nicoli N, Guidi GC, et al. Severe impairment of antioxidant system in human hepatoma. Cancer 1986;58:1658–62
  4. Mantha S V, Prasad M, Kalra J, Prasad K. Antioxidant enzymes in hypercholesterolemia and effects of vitamin E in rabbits. Atherosclerosis 1993;101:135–44
  5. Mccoy RN, Hill KE, Ayon MA, Stein JH, Burk RF. Oxidant stress following renal ischemia: changes in the glutathione redox ratio. Kidney Int 1988;33:812–7
  6. Carneiro SR, da Silva Lima AA, de Fátima Silva Santos G, de Oliveira CSB, Almeida MCV, da Conceição Nascimento Pinheiro M. Relationship between Oxidative Stress and Physical Activity in Women with Squamous Intraepithelial Lesions in a Cervical Cancer Control Program in the Brazilian Amazon. Oxid Med Cell Longev 2019;2019
  7. Wu R, Feng J, Yang Y, Dai C, Lu A, Li J, et al. Significance of serum total oxidant/antioxidant status in patients with colorectal cancer. PLoS One 2017;12:e0170003
  8. Sarı S. Farelerde Ehrlich Asit Solid tümör modelinde thymus sipyleus ve taurinin, böbrek MDA, Glutatyon, AOPP düzeylerine ve SOD aktivitesine etkileri. Gazi Üniversitesi Sağlık Bilimleri Enstitüsü; 2008
  9. Yavuz M, İlçe AÖ, Kaymakçı Ş, Bildik G, Dıramalı A. Meme kanserli hastaların tamamlayıcı ve alternatif tedavi yöntemlerini kullanma durumlarının incelenmesi. Turkiye Klin J Med Sci 2007;27:680–6
  10. Molassiotis A, Fernandez-Ortega P, Pud D, Ozden G, Scott JA, Panteli V, et al. Use of complementary and alternative medicine in cancer patients: a European survey. Ann Oncol 2005;16:655–63
  11. Chatterjee S, Kumar M, Kumar A. Chemomodulatory effect of Trigonella foenum graecum (L.) seed extract on two stage mouse skin carcinogenesis. Toxicol Int 2012;19:287
  12. Alshatwi AA, Shafi G, Hasan TN, Syed NA, Khoja KK. Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated in- EJMI 121 dependently by fas receptor change. Asian Pacific J Cancer Prev 2013;14:5783–8
  13. Raju J, Patlolla JMR, Swamy M V, Rao C V. Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon can