The Clinical Importance of Fibroblast Growth Factor 23 on Advanced Non-small Cell Lung Cancer Patients Without Druggable Alterations in Genes as EGFR or ALK or ROS1 Fibroblast Growth Factor 23 and Non-small Cell Lung Cancer

The median FGF 23 levels were 91.1±58.4 pg/ml and 92.5±60.8 pg/ml in squamous cell carcinoma and adenocarcinoma groups respectively (p=0.926).Conclusion: Our study suggests that high FGF-FGFR interaction may be causative for stage 3B and 4 NSCLC withoutdruggable alterations in genes as EGFR, ALK or ROS1 and is important in terms of suggesting the FGF pathway as a newtreatment target in NSCLC patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We aimed to investigate the relation between serum fibroblast growth factor (FGF) 23 levels and clinicopathologic features of stage 3B and 4 non-small cell lung cancer (NSCLC) patients without druggable alterations ingenes as epidermal growth factor receptor (EGFR) or rearrangements of the anaplastic lymphoma kinase (ALK) or c-ROSoncogene 1 (ROS1), by comparing healthy control group.Methods: This was a prospective, single-center study.

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Key Findings & Data:Newly diagnosed stage 3B and 4 NSCLC patients without druggable alterations in genes as EGFR, ALK or ROS1 and healthy control in similar age, without any chronic disease andvitamin D deficiency were enrolled in the study.

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Conclusion & Impact:The median FGF 23 levels were 91.1±58.4 pg/ml and 92.5±60.8 pg/ml in squamous cell carcinoma and adenocarcinoma groups respectively (p=0.926).Conclusion: Our study suggests that high FGF-FGFR interaction may be causative for stage 3B and 4 NSCLC withoutdruggable alterations in genes as EGFR, ALK or ROS1 and is important in terms of suggesting the FGF pathway as a newtreatment target in NSCLC patients.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objectives: We aimed to investigate the relation between serum fibroblast growth factor (FGF) 23 levels and clinicopathologic features of stage 3B and 4 non-small cell lung cancer (NSCLC) patients without druggable alterations ingenes as epidermal growth factor receptor (EGFR) or rearrangements of the anaplastic lymphoma kinase (ALK) or c-ROSoncogene 1 (ROS1), by comparing healthy control group.Methods: This was a prospective, single-center study. Newly diagnosed stage 3B and 4 NSCLC patients without druggable alterations in genes as EGFR, ALK or ROS1 and healthy control in similar age, without any chronic disease andvitamin D deficiency were enrolled in the study. Fibroblast growth factor 23 levels were compared between groups.Results: Forty men newly diagnosed stage 3B and 4 patients and 24 healthy men were enrolled. The median age ofpatients and controls were 54.7 and 53.1 years. The number of patients were 22 (55.0%) and 18 (45.0%) in stage 3B andstage 4 groups respectively. The mean FGF 23 level was calculated as 87.7±58.0 pg/ml in patients group and 63.1±11.4pg/ml in control group (p=0.045). Fibroblast growth factor 23 levels were 85.5±42.5 pg/ml and 89.6±69.1 in metastaticand non-metastatic patients respectively (p=0.532). The median FGF 23 levels were 91.1±58.4 pg/ml and 92.5±60.8 pg/ml in squamous cell carcinoma and adenocarcinoma groups respectively (p=0.926).Conclusion: Our study suggests that high FGF-FGFR interaction may be causative for stage 3B and 4 NSCLC withoutdruggable alterations in genes as EGFR, ALK or ROS1 and is important in terms of suggesting the FGF pathway as a newtreatment target in NSCLC patients.

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Cite This Article

SAKİN, A., CİHAN, Ş., ARICI, S., ÇEKİN, R., SEÇMELER, Ş., ATÇI, M. M., OCAK, B. (2022). The Clinical Importance of Fibroblast Growth Factor 23 on Advanced Non-small Cell Lung Cancer Patients Without Druggable Alterations in Genes as EGFR or ALK or ROS1 Fibroblast Growth Factor 23 and Non-small Cell Lung Cancer. Eurasian Journal of Medical Investigation, Cilt: 4 - Sayı: 3, 365–369. https://ajindex.com/articles/508633

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