SavedAdd your journal

Journals / Eurasian Journal of Medical Investigation / 2021 / Cilt: 5 - Sayı: 4

Partial Effect of Resveratrol on Wound Healing: Study on Wistar Albino Rats

Tayfun Bilgic
Nazli Caf
A. Nilhan Atsu
Pages
460–468
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results may shed light on new therapeutic approaches that can be used in the reversal of oxidative stress in wound-causing disease

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Resveratrol (RSV) is a polyphenol compound found naturally in fruits.
📊
Key Findings & Data:Methods: 16 rats were divided into two groups as the RSV and control.
💡
Conclusion & Impact:The results may shed light on new therapeutic approaches that can be used in the reversal of oxidative stress in wound-causing disease
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Resveratrol (RSV) is a polyphenol compound found naturally in fruits. Resveratrol's antioxidant, anti-aging, cardioprotective, anti-inflammatory, and anti-carcinogenic effects have been shown. This study aims to determine the effects of RSV on perfusion, neovascularization, inflammation, and granulation stages of wound healing in addition to its antioxidant capacity. Methods: 16 rats were divided into two groups as the RSV and control. Six excisions were made in each rat. Three exci- sions in each rat were sutured and the other 3 were left as open wounds. Topical RSV was applied to wounds of rats in the RSV group. Blood perfusion of the wounds in both groups was measured using the PeriScan PIM 3 System Laser Doppler Blood Perfusion Imager. Punch biopsies were taken for histopathological examinations and the evaluation of antioxidant capacity. Results: GPX level of the closed wounds of RSV group was higher compared to the control group. There was no statisti- cally significant difference in SOD and MDA levels between the groups. Neovascularization was registered higher in the open wounds of RSV group. Conclusion: RSV may be effective in wound healing. The results may shed light on new therapeutic approaches that can be used in the reversal of oxidative stress in wound-causing disease

🔖

Cite This Article

Bilgic, T., Caf, N., Atsu, A. N. (2022). Partial Effect of Resveratrol on Wound Healing: Study on Wistar Albino Rats. Eurasian Journal of Medical Investigation, Cilt: 5 - Sayı: 4, 460–468. https://ajindex.com/articles/508599

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Masson-Meyers DS, Andrade TAM, Caetano GF, Guimaraes FR, Leite MN, Leite SN, et al. Experimental models and methods for cutaneous wound healing assessment. Int J Exp Pathol 2020;101:21–37
  2. Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound re- pair and regeneration. Nature 2008;453:314–21
  3. Maver T, Maver U, Stana Kleinschek K, Smrke DM, Kreft S. A review of herbal medicines in wound healing. Int J Dermatol 2015;54:740–51
  4. Kaleci B, Koyuturk M. Efficacy of resveratrol in the wound healing process by reducing oxidative stress and promot- ing fibroblast cell proliferation and migration. Dermatol Ther 2020;33:14357
  5. Zhou X, Ruan Q, Ye Z, Chu Z, Xi M, Li M, et al. Resveratrol ac- celerates wound healing by attenuating oxidative stress-in- duced impairment of cell proliferation and migration. Burns 2021;47:133–9
  6. Meshkibaf MH, Maleknia M, Noroozi S. Effect of curcumin on gene expression and protein level of methionine sulfoxide re- ductase A (MSRA) SOD, CAT and GPx in Freund’s adjuvant in- flammation-induced male rats. J Inflamm Res 2019;12:241–9
  7. Sadi G, Konat D. Resveratrol regulates oxidative biomarkersand antioxidant enzymes in the brain of streptozotocin-in- duced diabetic rats. Pharm Biol 2016;54:1156–63
  8. Brito PM, Mariano A, Almeida LM, Dinis TCP. Resveratrol af- fords protection against peroxynitrite-mediated endothelial cell death: A role for intracellular glutathione. Chem Biol Inter- act 2006;164:157–66
  9. Li Y, Cao Z, Zhu H. Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotec- tion against oxidative and electrophilic stress. Pharmacol Res 2006;53:6–15
  10. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, et al. Oxidative stress: Harms and benefits for human health. Oxid Med Cell Longev 2017;2017:8416763
  11. Wang B, Peng L, Zhu L, Ren P. Protective effect of total flavo- noids from Spirodela polyrrhiza (L.) Schleid on human umbili- cal vein endothelial cell damage induced by hydrogen perox- ide. Colloids Surfaces B Biointerfaces 2007;60:36–40
  12. Brigelius-Flohé R, Maiorino M. Glutathione peroxidases. Bio- chim Biophys Acta 2013;1830:3289–303
  13. Younus H. Therapeutic potentials of superoxide dismutase. Int J Health Sci (Qassim) 2018;12:88–93
  14. Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: Produc- tion, metabolism, and signaling mechanisms of malondi- aldehyde and 4-hydroxy-2-nonenal. Oxid