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Journals / Eurasian Journal of Medical Investigation / 2021 / Cilt: 5 - Sayı: 1

Association between Beta-Hydroxybutyrate Levels and Survival in Sepsis Patients

İlker TAŞÇI
Bilgin Bahadır BAŞGÖZ
İsmail ERTÜRK
Gürhan TAŞKIN
Erdem SERTOĞLU
Ramazan ACAR
Halil KIZILÖZ
Metin UYANIK
Serhat ÖZER
Levent YAMANEL
Murat Emrah MAVİŞ
Canan PORUCU
Pages
39–44
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Beta-hydroxybutyrate levels were 20.4 µM (IQR=9.2-29.98 µM) in Group I and 54.9 µM (IQR=13.55–120.83µM) in Group II (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Sepsis is a systemic inflammatory response.
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Key Findings & Data:Beta-hydroxybutyrate is a product of ketogenesis that develops after the formation of coenzyme A from fatty acids.We aimed to evaluate the association between survival andbeta-hydroxybutyrate in sepsis patients.Methods: This is a single-center, prospective, cross-sectional study.
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Conclusion & Impact:Beta-hydroxybutyrate levels were 20.4 µM (IQR=9.2-29.98 µM) in Group I and 54.9 µM (IQR=13.55–120.83µM) in Group II (p
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: Sepsis is a systemic inflammatory response. Beta-hydroxybutyrate is a product of ketogenesis that develops after the formation of coenzyme A from fatty acids.We aimed to evaluate the association between survival andbeta-hydroxybutyrate in sepsis patients.Methods: This is a single-center, prospective, cross-sectional study. Between May 2018 and May 2019, 51 patients diagnosed with sepsis or septic shock in Gulhane Education and Research Hospital were included in the study. Patients,grouped as non-survivors (Group I) and survivors (Group II) were included in the study and followed for 28 days aftertheir initial blood samples obtained. Plasma beta-hydroxybutyrate level analyses were measured by using Liquid Chromatography Tandem Mass Spectrometry (LC-MS-MS).Results: Within 28 days, 22 patients died (Group I); 29 patients survived (Group II). The SOFA scores were 12.45±4.22 inGroup I and 9.97±3.30 (p=0.022) in Group II, and the APACHE-2 scores were 38.05±6.23 in Group I and 34.10±7.22(p=0.046)in Group II. Beta-hydroxybutyrate levels were 20.4 µM (IQR=9.2-29.98 µM) in Group I and 54.9 µM (IQR=13.55–120.83µM) in Group II (p

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Cite This Article

TAŞÇI, İ., BAŞGÖZ, B. B., ERTÜRK, İ., TAŞKIN, G., SERTOĞLU, E., ACAR, R., KIZILÖZ, H., UYANIK, M., ÖZER, S., YAMANEL, L., MAVİŞ, M. E., PORUCU, C. (2022). Association between Beta-Hydroxybutyrate Levels and Survival in Sepsis Patients. Eurasian Journal of Medical Investigation, Cilt: 5 - Sayı: 1, 39–44. https://ajindex.com/articles/508553

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