Journals / Eurasian Journal of Family Medicine / 2020 / Cilt: 9 - Sayı: 3

Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Patients with Hypothyroidism

Hipotiroidizmli Hastalarda Nötrofil-Lenfosit Oranı, Trombosit Lenfosit Oranı ve Ortalama Trombosit Hacminin Değerlendirilmesi

Pages
139–146
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We believe that prospective studies that evaluate neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume together with other inflammatory parameters are needed to predict the risk of microinflammation and cardiovascular disease in patients with hypothyroidism.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Our aim was the evaluation of neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume levels in the patient and control groups with hypothyroidism.
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Key Findings & Data:Methods: Our study was conducted with 111 participants; 68 patients and 43 healthy individuals as the control group.
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Conclusion & Impact:We believe that prospective studies that evaluate neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume together with other inflammatory parameters are needed to predict the risk of microinflammation and cardiovascular disease in patients with hypothyroidism.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Our aim was the evaluation of neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume levels in the patient and control groups with hypothyroidism. Methods: Our study was conducted with 111 participants; 68 patients and 43 healthy individuals as the control group. Thyroid hormones, lipid panel and hemogram levels of the participants were examined. Neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume levels were calculated. Results: Neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume levels were similar between the patients with subclinical and overt hypothyroidism and the control group. A positive correlation was found between neutrophil-lymphocyte ratio and platelet lymphocyte ratio. A negative correlation was found between platelet lymphocyte ratio and mean platelet volume. While there was no relationship between thyroid stimulating hormone and neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume; a negative correlation was found between neutrophil-lymphocyte ratio and free thyroxine. Conclusion: Neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume levels were similar in the hypothyroidism and control groups. We believe that prospective studies that evaluate neutrophil-lymphocyte ratio, platelet lymphocyte ratio and mean platelet volume together with other inflammatory parameters are needed to predict the risk of microinflammation and cardiovascular disease in patients with hypothyroidism.

Özet

Amaç: Bu çalışmadaki amacımız; hipotiroidizmi olan hasta ve kontrol grubunda nötrofil-lenfositoranı, trombosit lenfosit oranı ve ortalama trombosit hacmi düzeylerinin değerlendirilmesidir.Yöntem: Çalışmamız, 68 hasta ve 43 kişi kontrol grubu olmak üzere 111 katılımcı ilegerçekleştirilmiştir. Katılımcıların tiroid hormonları, lipid paneli ve hemogram düzeyleri incelendi.Nötrofil-lenfosit oranı, trombosit lenfosit oranı ve ortalama trombosit hacmi düzeyleri hesaplandı.Bulgular: Subklinik ve aşikar hipotiroidi olan hastalar ile kontrol grubu arasında nötrofil-lenfositoranı, trombosit lenfosit oranı ve ortalama trombosit hacmi düzeyi benzer bulundu. Nötrofil-lenfositoranı, trombosit lenfosit oranı arasında pozitif yönde korelasyon bulundu. Trombosit lenfosit oranı veortalama trombosit hacmi arasında negatif yönde korelasyon bulundu. Tiroid stimulan hormon ilenötrofil-lenfosit oranı, trombosit lenfosit oranı ve ortalama trombosit hacmi arasında ilişkibulunmazken; nötrofil-lenfosit oranı ile serbest tiroksin arasında negatif yönde korelasyon bulundu.Sonuç: Hipotiroidi ve kontrol grubunda nötrofil-lenfosit oranı, trombosit lenfosit oranı veortalama trombosit hacmi düzeyleri benzer bulundu. Hipotiroidizmde mikro inflamasyon vekardiyovasküler hastalık riskini öngörmede nötrofil-lenfosit oranı, trombosit lenfosit oranı ve ortalamatrombosit hacminin kullanılıp kullanılmadığını anlamak için diğer inflamatuar parametrelerin debirlikte değerlendirildiği prospektif çalışmaların yapılması gerektiğine kanaat getirildi.

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Cite This Article

PEKGÖR, S., ERYILMAZ, M. A., KAYA, İ. F. K. (2022). Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Patients with Hypothyroidism. Eurasian Journal of Family Medicine, Cilt: 9 - Sayı: 3, 139–146. https://ajindex.com/articles/508340

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References (14)

  1. Chaker, L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet 2017;390(10101):1550-62
  2. Shah KN, Gohil PV. Hypothyroidism and atherosclerosis: from etiology to pathophysiology. Sch Acad J Pharm 2014;3(1):89-96
  3. Ning N, Gao D, Triggiani V, Lacoviello M, Mitchell J, Ma R, et al. Prognostic role of hypothyroidism in heart failure: a meta-analysis. Medicine (Baltimore) 2015;94(30):e1159
  4. Imtiaz, F, Shafique K, Mirza SS, Ayoob, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012;5(1):2
  5. Sara JD, Zhang M, Gharib H, Lerman LO, Lerman A. Hypothyroidism is associated with coronary endothelial dysfunction in women. J Am Heart Assoc 2015;4(8):e002225
  6. Mayer OJ, Simon J, Filipovsky J, Plaskova M, Pikner R. Hypothyroidism in coronary heart disease and its relation to selected risk factors. Vasc Health Risk Manag 2006;2(4):499
  7. Cooper DS, Biondi B. Subclinical thyroid disease. Lancet 2012;379(9821):1142- 54
  8. Rhee CM, Curhan GC, Alexander EK, Bhan I, Brunelli SM. Subclinical hypothyroidism and survival: the effects of heart failure and race. J Clin Endocrinol Metab 2013;98(6):2326-36
  9. Hak AE, Pos HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 2000;132(4):270-8
  10. Oflazoglu U, Alacacioglu A, Kundak Somali I, Yuce M, Buyruk MA, Varol U, et al. Prognostic value of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients with colorectal carcinoma. Ann Oncol 2016;27(suppl_6):vi149- vi206
  11. Kuyumcu ME, Yesil Y, Ozturk ZA, Kizilarslanoglu C, Etgul S, Halil M, et al. The evaluation of neutrophillymphocyte ratio in Alzheimer's disease. Dement Geriatr Cogn Disord 2012;34(2):69-74
  12. Manatakis DK, Balafouta ST, Balalis D, Soulou VN, Korkolis DP, Sakorafas GH, et al. Association of baseline neutrophil-to-lymphocyte ratio with clinicopathological characteristics of papillary thyroid carcinoma. Int J of Endocrinol 2017;2017:7
  13. Dolan RD, Lim J, Mcsorley ST, Horgan PG, McMillan DC. The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: systematic review and metaanalysis. Sci Rep 2017;7(1):16717. doi: 10.1038/s41598-017-16955- 5
  14. Kilic E, Rezvani A, Toprak Erek A, Erman H, Ayhan Kesgin