AI Summary & Key Takeaways
AI InsightIt was determined that active fragment includes 4 carbon atoms. 14 molecules from 22 active and 2 molecules from 23 inactive compounds contain this fragment.
📌 3 Key Takeaways
Abstract
Antiulcer activities belong to the imidazo $[1,2-varpropto]$ pyridinyl alkyl benzoxazole derivatives were investigated according to Electron-Topological approach. A series of 45 compounds were divided as 22 active (Antiulcer activity>63.7) and 23 inactive (Antiulcer activity $leq$ 63,7). The Electron-Topological matrices were constituted for each one of the compounds under consideration. This matrices involves electronic and geometrical properties. It was determined that active fragment includes 4 carbon atoms. 14 molecules from 22 active and 2 molecules from 23 inactive compounds contain this fragment.
Özet
İmidazo $[1,2-varpropto]$ pridinil etil benzoxazol türevleri üzerinde antiülser aktiviteleri Elektron-Topolojik (ET) yaklaşıma göre incelenmiştir. 45 bileşik serisi 22'i aktif, (antiülser aktivitesi >63.7) 23'ü inaktif (antiülser aktivitesi $leq$ 63,7) olarak bölünmüştür. İncelenen her bir bileşik için elektron-topolojik matrisler oluşturulmuştur. Bu matrisler, elektronik ve geometrik özellikleri içerir. Aktif fragmentin 4 karbon atomu içerdiği belirlenmiştir. 22 aktif bileşikten 14 molekül ve 23 inaktif bileşikten 2 molekül bu fragmenti taşır.