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Journals / Erciyes Tıp Dergisi / 2004 / Cilt: 26 - Sayı: 3

The impact of the sentinel lymph node biopsy on the early stage breast cancer; Can it replace axillary dissection?

Erken evre meme kanserinde sentinel lenf nodu biyopsisinin yeri; Aksiller diseksiyonun yerini alabilir mi?

Sezai DEMİRBAŞ
Yavuz KURT
M. Levhi AKIN
Tuncay ÇELENK
A. İlker FİLKİZ
Şükrü YILDIRIM
Pages
119–125
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further randomized studies with more patients are required.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Several studies have displayed staining sentinel lymph node(s) (SLN) render regional metastases in the patients with breast cancer.
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Key Findings & Data:Results: There was a significant increase in the identification (97.4% vs. 59.3%) rate and significant improvement on the period of SLNB (18.2 vs. 27.4 min., p=0.023).
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Conclusion & Impact:Further randomized studies with more patients are required.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: Several studies have displayed staining sentinel lymph node(s) (SLN) render regional metastases in the patients with breast cancer. The present study was planned to verify if sentinel lymph node biopsy (SLNB) could replace axillary dissection in patients with early stage breast cancer. Materials and Methods: Sixty-five patients with early stage breast cancer were enrolled and SLNB was completed before the surgery. After SLNB was achieved, patients underwent level I-II axillary dissection. Results: There was a significant increase in the identification (97.4% vs. 59.3%) rate and significant improvement on the period of SLNB (18.2 vs. 27.4 min., p=0.023). The false negative rate was 8.1%. The upgrading occurred in two cases (14.3%). False negativity was in reasonable ratio, however; upgrading on stage of breast cancer occurred in 14% of patients. SLNs demonstrated tumoral origin with high accuracy (92%). Conclusion: In patients with early breast cancer with high morbidity, SLNB could replace axillary dissection . Further randomized studies with more patients are required.

Özet

Amaç: Bu prospektif çalışma erken evre meme kanserli hastalarda sentinel lenf nodu biyopsisinin (SLNB) aksiler (koltukaltı lenf bezleri) diseksiyonun yerini alıp alamayacağını ortaya koymak için planlanıp çalışılmıştır. Gereç ve Yöntem: 65 erken meme kanserli hastada belirlenmiş kanser cerrahisi öncesinde mavi vital boya (patent blueV %2 lik sol.) kullanılarak SLNB yapıldı. Takiben operasyon ve 1-2 düzey aksiler lenf nodu diseksiyonu yapılarak cerrahi prosedür her bir hasta için tamamlandı. Bulgular: Çalışma boyunca sentinel lenf nodu (SLN) bulmada belirgin bir gelişme gözlendi. SLNB zamanı da istatistiksel olarak belirgin kısaldı (18.2 dk-27.4 dk., p=0.023). Yanlış negatiflik %8.1 olarak bulunurken, evre yükselmesi ise %14.3 hastada gözlendi. Sınırlı sayıda hasta olsa da yeterli bir öğrenim periyodundan sonra hemen her hastada SLN nu bulundu ve SLNB’si aksiler yatağı yüksek doğruluk oranı ile gösterdi (%92). Sonuç: SLNBnin erken evre meme kanserli hastalarda morbiditesi yüksek aksiler diseksiyonun yerini alacağını düşünmekteyiz. Fakat daha çok hasta ile hazırlanmış geniş seriler ile randomize ve çok merkezli çalışmalara ihtiyaç vardır.

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Cite This Article

DEMİRBAŞ, S., KURT, Y., AKIN, M. L., ÇELENK, T., FİLKİZ, A. İ., YILDIRIM, Ş. (2022). The impact of the sentinel lymph node biopsy on the early stage breast cancer; Can it replace axillary dissection?. Erciyes Tıp Dergisi, Cilt: 26 - Sayı: 3, 119–125. https://ajindex.com/articles/502850

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