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Journals / Erciyes Tıp Dergisi / 2005 / Cilt: 27 - Sayı: 3

Effects of age on open field parameters in depression developed rats

Depresyon oluşturulan sıçanlarda yaşın açık alan parametrelerine etkisi

Mustafa ARSLAN
Ayşegül KÜÇÜK
Asuman GÖLGELİ
Pages
110–114
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Statistical differences were found only in line crossings, the indicator of locomotor activity (p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: We aimed to study the effects of age on open field parameters after the behavioural despair test, a depression model, in rats.
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Key Findings & Data:Results: After the behavioural despair test, all parameters in the open field decreased in both young and old rats, although these decreases were not statistically significant in the old rats (p>0.05).
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Conclusion & Impact:Statistical differences were found only in line crossings, the indicator of locomotor activity (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: We aimed to study the effects of age on open field parameters after the behavioural despair test, a depression model, in rats. Materials and Methods: Ten young and ten adult male rats were used. Before and after the behavioural depression session, the animals were individually placed in the open field in order to evaluate behavioural parameters. Results: After the behavioural despair test, all parameters in the open field decreased in both young and old rats, although these decreases were not statistically significant in the old rats (p>0.05). In addition, the decreases in grooming and defecation were not statistically significant in the young rats (p>0.05). All parameters increased in young rats compared to the aged rats in the open field. Statistical differences were found only in line crossings, the indicator of locomotor activity (p

Özet

Amaç: Çalışmamızda sıçanlara, deneysel depresyon modellerinden birisi olan davranışsal ümitsizlik testi uygulayarak, yaşın açık alan davranış parametrelerine etkisini araştırmayı amaçladık. Gereç ve Yöntem: 10 adet genç ve 10 adet yaşlı erkek sıçana davranışsal ümitsizlik ve açık alan testi uygulandı. Davranışşsal ümitsizlik testi öncesinde ve sonrasında hayvanlara açık alan testi uygulanarak davranış parametreleri test edildi. Bulgular: Genç ve yaşlı sıçanlarda davranışsal ümitsizlik testi sonrası kaydedilen açık alan parametrelerinin hepsinde, ümitsizlik testi öncesi uygulanan açık alan parametrelerine göre azalma gözlendi. Ancak bu azalma yaşlı sıçanlarda istatistiksel olarak anlamlı bulunmadı (p>0.05). Kaşınma ve defekasyondaki azalma genç sıçanlarda da anlamlı değildi (p>0.05).Yaşlı sıçanların açık alan test parametrelerinin hepsinde genç sıçanlara göre azalma gözlendi. İstatistiksel anlamlılık hayvanın lokomotor aktivitesini gösteren çizgi geçme sayısında ortaya çıktı (p

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Cite This Article

ARSLAN, M., KÜÇÜK, A., GÖLGELİ, A. (2022). Effects of age on open field parameters in depression developed rats. Erciyes Tıp Dergisi, Cilt: 27 - Sayı: 3, 110–114. https://ajindex.com/articles/502799

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