Journals / Erciyes Tıp Dergisi / 2011 / Cilt: 33 - Sayı: 3

Farklı uzunluklarda thiry-vella fistül oluşturulmuş ratlarda intestinal adaptif değişiklikler

Adaptive changes of bowel in rats with various length of thiry-vella fistulas

Pages
205–212
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Group 3 and Group 4 were significantly different from other groups (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: The aim of the current experimental study was to determine interaction between functional and dysfunctional bowel segments in terms of structural changes in the gut mucosa.
📊
Key Findings & Data:Materials and Methods: Twenty-two male rats were divided into four groups in which following operations were performed respectively: Group 1; sham operation, Group 2; 5% Thiry-Vella fistula, Group 3; 80% Thiry-Vella fistula, and Group 4; 5% Thiry-Vella fistula plus 75% bowel resection.
💡
Conclusion & Impact:Group 3 and Group 4 were significantly different from other groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: The aim of the current experimental study was to determine interaction between functional and dysfunctional bowel segments in terms of structural changes in the gut mucosa. Materials and Methods: Twenty-two male rats were divided into four groups in which following operations were performed respectively: Group 1; sham operation, Group 2; 5% Thiry-Vella fistula, Group 3; 80% Thiry-Vella fistula, and Group 4; 5% Thiry-Vella fistula plus 75% bowel resection. At the end of the 14 days, ileum in continuity and Thiry-Vella fistula samples were examined histologically.Results: Mucosal thickness in ileal samples in continuity were 605±24 µ, 615±14 µ, 731±16 µ, 860±44 µ, in Groups 1, 2, 3 and 4, respectively. Group 3 and Group 4 were significantly different from other groups (p

Özet

Amaç: Bu deneysel çalışmanın amacı, fonksiyonel ince barsak ile nonfonksiyonel ince barsak arasındaki karşılıklı etkileşime bağlı yapısal değişiklikleri incelemekti. Gereç and Yöntem: Otuz iki adet sıçan 4 gruba ayrıldı. Grup 1'e sham operasyonu, Grup 2'ye %5 Thiry-Vella fistül, Grup 3'e %80 Thiry-Vella fistül ve Grup 4'e %5 Thiry-Vella fistül+%75 barsak rezeksiyonu yapıldı. Fonksiyonel ileum ve Thiry-Vella fistül örnekleri 14ncü günün sonunda histolojik olarak incelendi.Bulgular: Fonksiyonel ileal örnelerin mukozal kalınlıkları sırasıyla Grup 1; 605±24 µ, Grup 2; 615±14 µ, Grup 3; 731±16 µ ve Grup 4; 860±44 µ, idi. Grup 3 ve 4 diğer iki gruptan anlamlı olarak farklıydı (p

🔖

Cite This Article

AKÇORA, B. (2022). Farklı uzunluklarda thiry-vella fistül oluşturulmuş ratlarda intestinal adaptif değişiklikler. Erciyes Tıp Dergisi, Cilt: 33 - Sayı: 3, 205–212. https://ajindex.com/articles/502519

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Williamson RC. Intestinal adaptation (second of two parts). Mechanisms of control. N Engl J Med 1978; 298(26): 1444 –1450
  2. Hanson WR, Rijke RPC, Plasier HM, Van Ewijk W, Osborne JW. The effect of intestinal resection on Thiry- Vella fistulae of jejunal and ileal origin in the rat: evidence for a systemic control mechanism of cell renewal. Cell Tissue Kinet 1977;10(6): 543–555
  3. Booth IW, Lander AD. Short bowel syndrome. Baillieres Clin Gastroenterol 1998; 12(4):739–773
  4. Sukhotnik I, Siplovich L, Shiloni E, Mor-Vaknin N, Harmon CM, Coran AG. Intestinal adaptation in short- bowel syndrome in infants and children: a collective review. Pediatr Surg Int 2002; 18(4): 258–263
  5. Vanderhoof JA. Short bowel syndrome. Neonat Gastroenterol 1996; 23(2): 377–386
  6. Chaet MS, Arya G, Ziegler MM, Warner BW. Epidermal growth factor enhances intestinal adaptation after massive small bowel resection. J Pediatr Surg 1994; 29(8):1035–1038
  7. Hanson WR, Osborne JW, Sharp JG. Compensation by the residual intestine after intestinal resection in the rat. I. Influence of amount of tissue removed. Gastroenterology 1977; 72(4 Pt 1):692–700
  8. Hanson WR, Osborne JW, Sharp JG. Compensation by the residual intestine after intestinal resection in the rat. II. Influence of postoperative time interval. Gastroenterology 1977; 72(4 Pt 1):701–705
  9. O’Loughlin E, Winter M, Shun A, Hardin JA, Gall DG. Structural and functional adaptation following jejunal resection in rabbits: Effect of epidermal growth factor. Gastroenterology 1994; 107(1):87–93
  10. Al-Mukhtar MYT, Sagor GR, Ghatei MA, Bloom SR, Wright NA. The role of pancreatico-biliary secretions in intestinal adaptation after resection and its relationship to plasma enteroglucagon. Br J Surg 1983; 70(7):398- 11) Johnson LR, Lichtenberger LM, Copeland EM, Dudrick SJ, Castro GA. Action of gastrointestinal structure and function. Gastroenterology 1975; 68(5 Pt 1):1184–1192
  11. Tappenden KA. Mechanisms of enteral nutrient- enhanced intestinal adaptation. Gastroenterology 2006; 130(2 Suppl 1):93–99
  12. Juno RJ, Knott AW, Erwin R, Warner BW. A Serum factor(s) after small bowel resection induces intestinal epithelial cell proliferation: effects of timing, site, and extent of resection. J Pediatr Surg 2000; 38(6): 868–874
  13. Dowling RH. Small bowel adaptation and its regulation. Scand J Gastroenterol Suppl 1982; 74:53–74
  14. Gleeson MH, Cullen J, Dowling RH. Intestinal structure and function after small bowel by-pass in th