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Journals / Erciyes Tıp Dergisi / 2012 / Cilt: 34 - Sayı: 2

Kronik hepatit C’de C-Kit pozitif hepatik progenitör hücrelerinin hastalığın takibinde rolü var mı?

İlyas ÖZARDALI
Celal ÇALIŞIR
Süda KORUK TEKİN
Muhammed Emin GÜLDÜR
Dilnur DİNÇOĞLU
Pages
44–49
Publication Date
2022-10-17
DOI
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⚡ TL;DR(Too Long; Didn't Read)

There was no statistically significant difference in c-Kit positivity status with respect to the ALT, AST or HCV RNAresults. c-Kit positivity increased with increasing hepatitisgrade (p

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Objective & Hypothesis:Objective: The aim of this study was to compare the clinical and pathological properties of cases of hepatitis C virus (HCV) infection with respect to the presence or absence of hepatic progenitor cells positive for the proto-oncogene c-Kit (CD117) in hepatic tissue.
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Key Findings & Data:Material and Methods: The study was performed on hepatic biopsy specimens from 61 cases with HCV infection.
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Conclusion & Impact:There was no statistically significant difference in c-Kit positivity status with respect to the ALT, AST or HCV RNAresults. c-Kit positivity increased with increasing hepatitisgrade (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to compare the clinical and pathological properties of cases of hepatitis C virus (HCV) infection with respect to the presence or absence of hepatic progenitor cells positive for the proto-oncogene c-Kit (CD117) in hepatic tissue. Material and Methods: The study was performed on hepatic biopsy specimens from 61 cases with HCV infection. Stained hepatic biopsy slides were examined. Immunohistochemical staining was performed using an anti-c-Kit antibody. The cases were divided into four groups (minimal, mild, moderate and severe according to their total hepatic activity index and into two groups (none/mild, moderate/severe) according to fibrosis grade. Results: c-Kit-positive oval cells were detected in 30 cases(49.1%). There was no statistically significant difference in c-Kit positivity status with respect to the ALT, AST or HCV RNAresults. c-Kit positivity increased with increasing hepatitisgrade (p

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Cite This Article

ÖZARDALI, İ., ÇALIŞIR, C., TEKİN, S. K., GÜLDÜR, M. E., DİNÇOĞLU, D. (2022). Kronik hepatit C’de C-Kit pozitif hepatik progenitör hücrelerinin hastalığın takibinde rolü var mı?. Erciyes Tıp Dergisi, Cilt: 34 - Sayı: 2, 44–49. https://ajindex.com/articles/502469

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