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Journals / Erciyes Medical Journal / 2022 / Cilt: 44 - Sayı: 3

Leptin Prevents U46619- and Angiotensin II-Elicited Contraction in Isolated Human Umbilical Vessels

İpek DUMAN
Burak Cem SONER
Salim Yalçın İNAN
Ayşe Saide ŞAHİN
Pages
324–329
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The leptin-elicited relaxation in U46619-contracted vessels was greater in veins than in arteries (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study investigated the vasoactive responses of quiescent and pre-contracted isolated human umbilical veins and arteries to cumulative leptin.
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Key Findings & Data:Materials and Methods: The vasoactive response of umbilical vessels pre-contracted with U46619 (10-10M) and angiotensin II (10-6M) to cumulative leptin (10-11-10-7M) were recorded in vitro.
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Conclusion & Impact:The leptin-elicited relaxation in U46619-contracted vessels was greater in veins than in arteries (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study investigated the vasoactive responses of quiescent and pre-contracted isolated human umbilical veins and arteries to cumulative leptin. Materials and Methods: The vasoactive response of umbilical vessels pre-contracted with U46619 (10-10M) and angiotensin II (10-6M) to cumulative leptin (10-11-10-7M) were recorded in vitro. Results: Leptin did not affect the artery or vein basal tonus (p=1). The leptin-elicited relaxation in U46619-contracted vessels was greater in veins than in arteries (p

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Cite This Article

DUMAN, İ., SONER, B. C., İNAN, S. Y., ŞAHİN, A. S. (2022). Leptin Prevents U46619- and Angiotensin II-Elicited Contraction in Isolated Human Umbilical Vessels. Erciyes Medical Journal, Cilt: 44 - Sayı: 3, 324–329. https://ajindex.com/articles/502098

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