Journals / Endokrinolojide Yönelişler / 2004 / Cilt: 13 - Sayı: 5

Amiodarone induced thyroid disfunction: Case report

Amiodarona bağlı gelişen tiroid disfonksiyonu: Olgu sunumu

Pages
167–169
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

After the examinations, we found type 2 amiodarone-induced thyrotoxicosis and gave treatment to her.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:One of the best known side effects of amiodarone which is using for repeating arrhythmias is thyroid disfunction.
📊
Key Findings & Data:It is a benzofuran derivative and includes 75mg iodine at 200mg per tablet.
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Conclusion & Impact:After the examinations, we found type 2 amiodarone-induced thyrotoxicosis and gave treatment to her.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

One of the best known side effects of amiodarone which is using for repeating arrhythmias is thyroid disfunction. It is a benzofuran derivative and includes 75mg iodine at 200mg per tablet. So it causes two types thyrotoxicosis. Our patient is 54 years old woman and using amiodarone for 1 year. Firstly hypothyroidism was found in another medical center and treated; and then when she came to us, hyperthyroidism was determined. After the examinations, we found type 2 amiodarone-induced thyrotoxicosis and gave treatment to her.

Özet

Tekrarlayan aritmilerin tedavisinde sıklıkla kullanılmakta olan amiodaronun en iyi bilinen yan etkilerinden birisi tiroid disfonksiyonudur. Amiodaron bir benzofuran türevi olup, 200mg tabletinde 75mg iyot içermektedir. Buna bağlı olarak hastalarda iki tip amiodarona bağlı tirotoksikoza sebep olmaktadır. Hastamız 54 yaşında, bayan ve 1 senedir ventriküler aritmi nedeniyle amiodaron kullanmaktaydı, ilk olarak başka bir merkezde hipotiroidi görülerek tedavisi başlanmış olan hasta bize başvurduğunda hipertiroidi tablosu mevcuttu. Yapılan tetkikler sonucu hastamızda amiodarona bağlı tip 2 tirotoksikoz tanısı konularak tedavi verildi.

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Cite This Article

TARÇIN, O., TARÇIN, Ö. (2022). Amiodarone induced thyroid disfunction: Case report. Endokrinolojide Yönelişler, Cilt: 13 - Sayı: 5, 167–169. https://ajindex.com/articles/500862

References (14)

  1. McEvoy GK.AHFS drug informalion 2000, Bethesda, MD: American Society of Health-System Pharmacists
  2. Podrid PJ. Amiodarone:reevaluation of an old drug. Ann Intern Med 1995. 122: 689-700
  3. Kennedy HL, Griffiths H, Gray TA. Amodarone and the rhyroid. Clin Chem 1989. 35: 1882-1887
  4. Latini R, Tognoni G, Kates RE. Clinical pharmacokinetics of amiodarone. Clin Pharmacokinet 1984. 9: 136-156
  5. Vandergheynst F, Lienart E, Ducobu J. Amiodarone and Thyroid disor ders. Rev Med Brux 1999; 20(5): 411-7.and thyroid function. Prog Cardiovasc Dis 1989. 31: 427-137
  6. Cappiello E, Boldorini R, Tosoni A, Piraneo S, Beınaaconi R, Raggi U. Ultrasutructural evidence of thyroid da m age in amiodarone-induced thyrotoxicosis.J Endocrinol Invesl 1995; 18(11): 862-8
  7. Martirio E, Safran M, Aghini-Lombaıdi E,et al. Environmental iodine in- take and thyroid dysfonelion during chronic amiodarone therapy. Ann Intern Med 1984. 101: 28-34
  8. Nademanee K, Piwonka RW, Singh BN, Hershman JM. Amiodarone and thyroid function. Prog Cardiovasc Dis 1989. 31: 427-137
  9. Norman MP, Lavin TN. Antagonism of thyroid hormone action by ami odarone in rat pituitary tumor cells. J Clin Invest 1989- 83:306-313 10. Franklyn JA, Davis JH, Gammage MD, Littler WA. Kamsden DB, Shep-pard MC. Amiodarone and thyroid hormone action, Clin Endocrinol (Oxf) 1985. 22: 257-264
  10. Larioa ST, Zaw KM, Ganti AK, Newman W, Akimvande AO. Amioda rone-induced thyrotoxicosis presenting as hypokalemic periodic paralysis, South Med J 2002; 95(11): 1326-8
  11. Shiga T, Wakaumi M, Matsuda N, Slioda M, Hagiwara N, Sato K, Ka-sanuki II. Amiodarone-induced thyroid dysfunction and ventricular tachyarrhytmias during long-term therapy in Japan. Jpn Circ J 2001; 65: 958-960
  12. Marlin-Du Pan R, Konfino O, Zimmermann M, Treatment of amiodarone-induced hypeithyroidism:conicosteroids or potassium Perchlorate? What value do interleukin-6 levels have?.Rev Med Suisse Komande 1997. 117(10): 805-10
  13. Martino E, Agbjini P, Mariotri S, Bartalena L, Bravcrman L, Pinchers A. Amiodarone: a common source of iodine-induced thyrotoxicosis. Horm Res 1987. 26: 158-171
  14. Martino E, Aghini-Lombardi P, Mariotti S,et al. Treatment of amiodaro- ne associated thyrotoxicosis by simultaneous administration of potassium Perchlorate and inethimazole. J Endocrinol Invest 1986, 9201- 207, 16. Reichert LJ, de Rooy HA. Treatment of amiodarone induced hyperthyroidism with potassium perchlonite and methimazole during amiodarone treatment. Br Med J