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Journals / Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) / 2010 / Cilt: 21 - Sayı: 3

Melatonin sıçan modelinde kırık iyileşmesini hızlandırır

Melatonin promotes fracture healing in the rat model

Figen NARİN
Canan HAZLICI
Mithat ÖNER
Mehmet HALICI
Ahmet GÜNEY
Özlem CANÖZ
Pages
172–177
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: Malondialdehyde levels in group 2 decreased at days 3, 7, 14, and 28 compared to control values (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: In this study, we investigated the effect of melatonin on fracture healing in the rat tibia model by using biochemical and histopathologic methods.
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Key Findings & Data:Materials and methods: In this study 80 male Sprague- Dawley rats were randomized into two groups, a control group (Group 1) and melatonin group (Group 2) with eight rats per group according to the day of sacrifice (Days 1, 3, 7, 14 and 28).
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Conclusion & Impact:Results: Malondialdehyde levels in group 2 decreased at days 3, 7, 14, and 28 compared to control values (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: In this study, we investigated the effect of melatonin on fracture healing in the rat tibia model by using biochemical and histopathologic methods. Materials and methods: In this study 80 male Sprague- Dawley rats were randomized into two groups, a control group (Group 1) and melatonin group (Group 2) with eight rats per group according to the day of sacrifice (Days 1, 3, 7, 14 and 28). The fractures were produced by the manual breakage using plate-bending devices, placed at the distal 3rd of the right tibia. Group 2 received 30 mg/kg/day melatonin and group 1 1% alcohol in saline 5 ml/kg/day intraperitoneally during the experiment. Plasma Malondialdehyde (MDA) levels, activity of superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured biochemically. The fracture healing was evaluated using a five-point scale defined by Allen et al. Results: Malondialdehyde levels in group 2 decreased at days 3, 7, 14, and 28 compared to control values (p

Özet

Amaç: Bu çalışmada sıçan tibia modelinde melatoninin kırık iyileşmesi üzerine olan etkileri biyokimysal ve histolojik yöntemle araştırıldı. Gereç ve yöntemler: Bu çalışmada 80 adet erkek Sprague- Dawley sıçan kontrol grubu (Grup 1) ve melatonin grubu (Grup 2) olarak iki gruba ayrıldı, her gruptan sekizer sıçan 1, 3, 7, 14 ve 28. günlerde sakrifiye edilecek şekilde randomize edildi. Kırıklar, plak eğme cihazı kullanılarak elle kırma yöntemiyle sağ tibianın distal 1/3’ünde oluşturuldu. Grup 2’ye deney süresince 30 mg/kg/gün melatonin, grup 1’e ise salin solüsyonu içerisinde %1’lik alkol 5 ml/kg/gün intraperitoneal yolla verildi. Plazma malondialdehit (MDA) seviyeleri ile süperoksit dismutaz (SOD) ve miyeloperoksidaz (MPO) aktiviteleri biyokimyasal yolla ölçüldü. Kırık iyileşmesi Allen ve ark.nın beş dereceli skalası kullanılarak değerlendirildi. Bulgular: Malondialdehit seviyesi, grup 2’de 3, 7, 14 ve 28. günlerde kontrol değerlerine göre düşük bulundu. (p

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Cite This Article

NARİN, F., HAZLICI, C., ÖNER, M., HALICI, M., GÜNEY, A., CANÖZ, Ö. (2022). Melatonin sıçan modelinde kırık iyileşmesini hızlandırır. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), Cilt: 21 - Sayı: 3, 172–177. https://ajindex.com/articles/498706

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