Journals / Ege Tıp Dergisi / 2021 / Cilt: 60 - Sayı: 3

Relationship of multiple myeloma with ABO blood groups

Multipl miyelomun ABO kan grupları ile ilişkisi

Pages
274–280
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

More comprehensive studies are needed on this subject.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Multiple myeloma is a heterogeneous, incurable haematological cancer that occurs as a result ofthe clonal proliferation of plasma cells.
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Key Findings & Data:We investigated the blood group distribution of multiple myeloma patients and whethertheir blood groups are related to immunoglobulin type.Materials and Methods: 75 multiple myeloma patients and 73128 control group were included in thestudy, which was planned retrospectively.
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Conclusion & Impact:More comprehensive studies are needed on this subject.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Multiple myeloma is a heterogeneous, incurable haematological cancer that occurs as a result ofthe clonal proliferation of plasma cells. The impact of blood groups on human diseases and/or theirrole in the prognosis of the disease has attracted the attention of scientists since the discovery ofblood groups. We investigated the blood group distribution of multiple myeloma patients and whethertheir blood groups are related to immunoglobulin type.Materials and Methods: 75 multiple myeloma patients and 73128 control group were included in thestudy, which was planned retrospectively. The statistical evaluation was performed by using StatisticalPackage for Social Sciences (SPSS) software for Windows 20 (IBM SPSS Inc., Chicago, IL). Thenormal distribution of the data was evaluated with the Kolmogorov-Smirnov test.Results: In multiple myeloma patients, the rate of A and B blood groups was low, and the rate of Oand AB blood groups was high. Heavy chain IgA ratio was higher in B blood group compared to otherblood groups. On the other hand, IgG ratio was found higher in O blood group compared to otherblood groups.Conclusion: A relationship has been found between immunoglobulin type and blood types in multiplemyeloma. More comprehensive studies are needed on this subject.

Özet

Amaç: Multipl myelom plazma hücrelerinin klonal proliferasyonu sonucu oluşan, heterojen, kür sağlanamayan hematolojik bir kanserdir. Kan gruplarının insan hastalıklarına katkısı ve/veya hastalık seyrindeki rolü kan gruplarının keşfinden bu yana bilim insanlarının ilgisini çekmiştir. Multipl myelom hastalarının kan grubu dağılımını ve kan gruplarının immunglobulin tipi ile ilişkisinin olup olmadığını araştırdık. Gereç ve Yöntem: Retrospektif planlanan çalışmaya 75 multipl myelom hastası ve 73128 kontrol grubu dahil edildi. İstatistiksel değerlendirme Statistical Package for Social Sciences (SPSS) for Windows 20 (IBM SPSS Inc., Chicago, IL) programı kullanılarak yapıldı. Verilerin normal dağılımı Kolmogorov-Smirnov testi ile değerlendirildi. Bulgular: Multipl myelom hastalarında A ve B kan grupları oranı düşük, O ve AB kan grupları oranı yüksek saptandı. B kan grubunda ağır zincir IgA oranı diğer kan gruplarına kıyasla daha yüksek saptandı. IgG oranı ise O kan grubunda diğer kan gruplarına kıyasla daha yüksek saptandı. Sonuç: Multipl myelomda immunoglobulin tipi ile kan grupları arasında bir ilişki bulunmuştur. Bu konuda yapılacak daha kapsamlı çalışmalara ihtiyaç vardır

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Cite This Article

AVCI, B. Ş., BANKIR, M., AÇIK, D. Y. (2022). Relationship of multiple myeloma with ABO blood groups. Ege Tıp Dergisi, Cilt: 60 - Sayı: 3, 274–280. https://ajindex.com/articles/496055

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