Journals / Ege Tıp Dergisi / 2022 / Cilt: 61 - Sayı: 2

The role of systemic inflammatory markers in prediction of medical treatment failure in patients with tubo-ovarian abscess

Tuboovaryan apseli hastalarda sistemik inflamatuvar belirteçlerin medikal tedavi başarısızlığını öngörmedeki yeri

Pages
184–191
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CRP could be used as a marker in predicting the need for surgical treatment in patients with TOA.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Aimed to evaluate the role of systemic inflammatory markers and Aspartate aminotransferase to Platelet Ratio Index (APRI) sore in predicting medical treatment failure in patients with Tubo-ovarian abscess (TOA).
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Key Findings & Data:Materials and Methods: Patients (n=240) hospitalized with a diagnosis of TOA between August 2016 - October 2020 were included in the study.
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Conclusion & Impact:CRP could be used as a marker in predicting the need for surgical treatment in patients with TOA.
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: Aimed to evaluate the role of systemic inflammatory markers and Aspartate aminotransferase to Platelet Ratio Index (APRI) sore in predicting medical treatment failure in patients with Tubo-ovarian abscess (TOA). Materials and Methods: Patients (n=240) hospitalized with a diagnosis of TOA between August 2016 - October 2020 were included in the study. Patients' demographic and clinical characteristics and mean C-Reactive protein (CRP) level, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and APRI score measured on admission were also recorded. The role of these parameters was investigated in predicting medical treatment failure in patients who only received medical treatment or who needed surgical treatment. Results: The mean age (40.95 ± 6.96 vs. 38.09 ± 7.69), abscess size (67.57 ± 19.86 mm vs. 52.78 ± 16.63 mm), CRP level, (140.61 ± 110.88 vs. 75.24 ± 36.64 mg/L), white blood cell count (13818.86 ± 5445.80 and 11845.31 ± 4424.39 μL), neutrophil count (11146.81 ± 5284.83 and 9242.03 ± 4278.60 μL) and NLR (9.52 ± 6.88 and 6.64 ± 6.30) of patients who received surgical treatment were significantly higher than those who received only medical treatment. In receiver operating characteristics (ROC) analysis area under the curve (AUC) 0.607 was statistically significant for CRP with a cut-off value of 11.57 to predict medical treatment failure (95% 0.531-0.682, sensitivity 63.3%, specificity 55.4%). Conclusion: NLR, PLR and APRI score are ineffective in predicting the need for surgical treatment. CRP could be used as a marker in predicting the need for surgical treatment in patients with TOA.

Özet

Amaç: Tuboovaryan apse (TAO) olgularında sistemik inflamatuar belirteçler ve Aspartate aminotransferaz/Platelet Index (APRİ) skorun medikal tedavi başarısızlığını öngörmede yeri olup olmadığı araştırıldı. Gereç ve Yöntem: Ağustos 2016 – Ekim 2020 tarihleri arasında TOA tanısı ile yatırılarak tedavi edilen 240 hasta çalışmaya dâhil edildi. Hastaların demografik ve klinik özellikleri, tanı anında bakılan C- Reaktif protein (CRP), Nötrofil lenfosit oranı (NLR), Platelet lenfosit oranı (PLR) ve APRI skoru dosya kayıtlarından elde edildi. Sadece medikal (n=74) tedavi alan veya cerrahi tedavi gereken hastalarda (n=166) bu parametrelerin medikal tedavi başarısızlığını öngörmedeki yerleri araştırıldı. Bulgular: Cerrahi tedavi alan hastaların sadece medikal tedavi alanlara göre ortalama yaşı (40,95 ± 6,96 ve (38,09 ± 7,69), apse boyutu (67,57 ± 19,86 mm ve 52,78 ± 16,63 mm), CRP değeri (140,61 ± 110,88 ve 75,24 ± 36,64 mg/L), beyaz küre (13818,86 ± 5445,80 ve 11845,31 ± 4424,39 μL), nötrofil (11146,81 ± 5284,83 ve 9242,03 ± 4278,60 μL) ve NLR değeri (9.52 ± 6.88 ve 6.64 ± 6.30) anlamlı olarak daha yüksek bulundu. Receiver Operating Characteristics (ROC) eğrisi analizi (95% 0,531-0,682) ile CRP’nin >11,57 olmasının %63,3 sensitivite, %55,4 spesifite ile medikal tedavi başarısızlığını öngördüğü saptandı. Sonuç: NLR, PLR ve APRI skoru cerrahi tedavi gereksinimini öngörmede etkisizdir. CRP başvuru anında cerrahi tedavi gereksinimini belirlemek adına kullanılabilecek bir belirteçtir

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Cite This Article

AKSAKAL, S. E., SAÇINTI, H. G., ALTINBAŞ, Ş. K., TAPISIZ, Ö. L., ÜSTÜN, Y. E. (2022). The role of systemic inflammatory markers in prediction of medical treatment failure in patients with tubo-ovarian abscess. Ege Tıp Dergisi, Cilt: 61 - Sayı: 2, 184–191. https://ajindex.com/articles/496010

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