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Journals / Ege Klinikleri Tıp Dergisi / 2020 / Cilt: 58 - Sayı: 2

Oocyte Triggering in Overweight and Obese Patients Undergo ICSI: 250 µg Versus 500 µg Recombinant Hcg

ICSI Yapılacak Fazla Kilolu ve Obez Hastalarda Oosit Tetikleme: 250 µg veya 500 µg Recombinant hCG

İlker SELÇUK
Gökhan BOYRAZ
Gürkan BOZDAĞ
Lale KARAKOÇ SÖKMENSÜER
İbrahim ESİNLER
Pages
1–6
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Implantation rates (12.9% vs 32.4%, p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim:To evaluate the impact of recombinant-human chorionic gonadotropin (r-hCG) dose; 250 µg or 500 µg, on intracytoplasmic sperm injection (ICSI) outcomes in overweight and obese patients.
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Key Findings & Data:Materials and Methods: Fifty-eight consecutive infertile patients with a body mass index (BMI) ≥25kg/m2 who underwent ICSI were retrospectively evaluated according to the r-hCG dosage used to trigger ovulation.
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Conclusion & Impact:Implantation rates (12.9% vs 32.4%, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim:To evaluate the impact of recombinant-human chorionic gonadotropin (r-hCG) dose; 250 µg or 500 µg, on intracytoplasmic sperm injection (ICSI) outcomes in overweight and obese patients. Materials and Methods: Fifty-eight consecutive infertile patients with a body mass index (BMI) ≥25kg/m2 who underwent ICSI were retrospectively evaluated according to the r-hCG dosage used to trigger ovulation. We included patients between 20-38 years of age without polycystic ovarian syndrome and poor ovarian reserve. Group I was constituted of 16 patients (21 cycles) who get 250 µg r-hCG for oocyte triggering, and Group II was constituted of 42 patients (55 cycles) who get 500 µg r-hCG. Results: The mean age and mean body mass indexes (28.63.7 and 28.43.2) were similar between the Group I and II. Germinal vesicle oocytes/oocyte-cumulus complexes ratio (14.6% vs 8.9%), rate of arrested embryos (18.0% vs 7.5%) and rate of embryos with multinucleation (14.2% vs 7.2%) were significantly higher in Group I. The metaphase II oocytes/oocyte-cumulus complexes ratio (76.9% vs 82.9%), the rate of embryos with ≥7 blastomeres on day 3 (61.4 %vs 79.4%) and rate of blastocyst transfer (11.8% vs 51.8%) were significantly higher in Group II. Implantation rates (12.9% vs 32.4%, p

Özet

Amaç: Fazla kilolu ve obez hastalarda, 250 µg veya 500 µg recombinant-human chorionic gonadotropin (r-hCG) dozunun intrastoplasmik sperm enjeksiyonu (Intracytoplasmic sperm injection/ICSI) sonuçları üzerine etkisini değerlendirmek. Gereç ve yöntemler: Vücut kitle indeksi (VKİ) ≥25kg/m2 olan ICSI yapılmış 58 ardışık inferil hasta ovulasyonun tetiklenmesi için verilmiş olan r-hCG dozuna göre retrospektif olarak analiz edilmiştir. Polikistik over sendromu veya kötü over rezervi olmayan 20-38 yaş arası hastalar dahil edilmiş olup, Grup I oosit tetiklenmesi için 250 µg r-hCG almış olan 16 hasta (21 siklus) ve Grup II 500 µg r-hCG almış olan 42 hastadan (55 siklus) oluşmuştur. Bulgular: Grup I ve II arasında ortalama yaş ve VKİ (28.63.7 ve 28.43.2) benzerdi. Germinal vezikül oosit/oosit-kumulus yapısı oranı (14.6% vs 8.9%), duraklamış embriyo oranı (18.0% vs 7.5%) and multinukleasyon olan embriyo oranı (14.2% vs 7.2%) Grup I’de anlamlı olarak daha yüksekti. Metafaz II oosit/oosit-kumulus yapısı oranı (76.9% vs 82.9%), 3. günde≥7 blastomer olan embriyo oranı (61.4% vs 79.4%) ve blastokist transfer oranı (11.8% vs 51.8%) Grup II’de anlamlı olarak daha yüksekti. İmplantasyon oranları (12.9% vs 32.4%, p

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Cite This Article

SELÇUK, İ., BOYRAZ, G., BOZDAĞ, G., SÖKMENSÜER, L. K., ESİNLER, İ. (2022). Oocyte Triggering in Overweight and Obese Patients Undergo ICSI: 250 µg Versus 500 µg Recombinant Hcg. Ege Klinikleri Tıp Dergisi, Cilt: 58 - Sayı: 2, 1–6. https://ajindex.com/articles/495654

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