SavedAdd your journal

Journals / Ege Klinikleri Tıp Dergisi / 2020 / Cilt: 58 - Sayı: 1

Covid-19 Managementin Pregnancy

Gebelikte Covid-19 Yönetimi

Ahmet Akın SİVASLIOĞLU
Gülin FEYKAN YEĞİN
Mehmet Ferdi KINCI
Pages
50–54
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

ThenumberofindividualsinfectedwithSARS-CoV-2virushasbeenincreasingdaybyday.Overtime,apparently,agrowingnumberofpregnantwomenwillbecomeinfectedwiththisviruswhichleadstothediseaseCovid-19.ThenumberofstudiesisinsufficienttoconcludeontheprognosisofCovid-19duringpregnancy;however,availablestudiessuggestabetterprognosiscomparedtothatofSARSandMERS.Noviruswasfoundinamnioticfluid,vaginalsecretions,cordblood,orplacenta.Existingstudiessuggestanincreasedriskofpretermlabor.Ourprimarygoalshouldbepreventionofcontractingthevirusandtostopitsfurthertransmission,ifcontracted.Hospitalizationisnotindicatedforthosewhoremainasymptomaticbuttheircompliancewiththeisolationprecautionsisparamount.Therehasbeennoconsensusonroutinepregnancyfollow-ups.Obstetriciansshoulddecideonthefollow-upfrequencypayingparticularattentiontotheimportanceoffirsttrimesterscreeningandUSGscanatweeks18to22.Forsymptomaticpregnantwomen,currenttreatmentapproachiscomposedoflopinavir/ritonavirandhydroxychloroquine.Wheretocolyticagentsarerequiredduetoincreasedriskofpretermlabor,nifedipineshouldbepreferredasthetreatmentoffirstchoice.Useofindomethacin,ontheotherhand,isnotrecommendedasitpromotesACE-2expression.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:ThenumberofindividualsinfectedwithSARS-CoV-2virushasbeenincreasingdaybyday.Overtime,apparently,agrowingnumberofpregnantwomenwillbecomeinfectedwiththisviruswhichleadstothediseaseCovid-19.ThenumberofstudiesisinsufficienttoconcludeontheprognosisofCovid-19duringpregnancy;however,availablestudiessuggestabetterprognosiscomparedtothatofSARSandMERS.Noviruswasfoundinamnioticfluid,vaginalsecretions,cordblood,orplacenta.Existingstudiessuggestanincreasedriskofpretermlabor.Ourprimarygoalshouldbepreventionofcontractingthevirusandtostopitsfurthertransmission,ifcontracted.Hospitalizationisnotindicatedforthosewhoremainasymptomaticbuttheircompliancewiththeisolationprecautionsisparamount.Therehasbeennoconsensusonroutinepregnancyfollow-ups.Obstetriciansshoulddecideonthefollow-upfrequencypayingparticularattentiontotheimportanceoffirsttrimesterscreeningandUSGscanatweeks18to22.Forsymptomaticpregnantwomen,currenttreatmentapproachiscomposedoflopinavir/ritonavirandhydroxychloroquine.Wheretocolyticagentsarerequiredduetoincreasedriskofpretermlabor,nifedipineshouldbepreferredasthetreatmentoffirstchoice.Useofindomethacin,ontheotherhand,isnotrecommendedasitpromotesACE-2expression.
📊
Key Findings & Data:ThenumberofindividualsinfectedwithSARS-CoV-2virushasbeenincreasingdaybyday.Overtime,apparently,agrowingnumberofpregnantwomenwillbecomeinfectedwiththisviruswhichleadstothediseaseCovid-19.ThenumberofstudiesisinsufficienttoconcludeontheprognosisofCovid-19duringpregnancy;however,availablestudiessuggestabetterprognosiscomparedtothatofSARSandMERS.Noviruswasfoundinamnioticfluid,vaginalsecretions,cordblood,orplacenta.Existingstudiessuggestanincreasedriskofpretermlabor.Ourprimarygoalshouldbepreventionofcontractingthevirusandtostopitsfurthertransmission,ifcontracted.Hospitalizationisnotindicatedforthosewhoremainasymptomaticbuttheircompliancewiththeisolationprecautionsisparamount.Therehasbeennoconsensusonroutinepregnancyfollow-ups.Obstetriciansshoulddecideonthefollow-upfrequencypayingparticularattentiontotheimportanceoffirsttrimesterscreeningandUSGscanatweeks18to22.Forsymptomaticpregnantwomen,currenttreatmentapproachiscomposedoflopinavir/ritonavirandhydroxychloroquine.Wheretocolyticagentsarerequiredduetoincreasedriskofpretermlabor,nifedipineshouldbepreferredasthetreatmentoffirstchoice.Useofindomethacin,ontheotherhand,isnotrecommendedasitpromotesACE-2expression.
💡
Conclusion & Impact:ThenumberofindividualsinfectedwithSARS-CoV-2virushasbeenincreasingdaybyday.Overtime,apparently,agrowingnumberofpregnantwomenwillbecomeinfectedwiththisviruswhichleadstothediseaseCovid-19.ThenumberofstudiesisinsufficienttoconcludeontheprognosisofCovid-19duringpregnancy;however,availablestudiessuggestabetterprognosiscomparedtothatofSARSandMERS.Noviruswasfoundinamnioticfluid,vaginalsecretions,cordblood,orplacenta.Existingstudiessuggestanincreasedriskofpretermlabor.Ourprimarygoalshouldbepreventionofcontractingthevirusandtostopitsfurthertransmission,ifcontracted.Hospitalizationisnotindicatedforthosewhoremainasymptomaticbuttheircompliancewiththeisolationprecautionsisparamount.Therehasbeennoconsensusonroutinepregnancyfollow-ups.Obstetriciansshoulddecideonthefollow-upfrequencypayingparticularattentiontotheimportanceoffirsttrimesterscreeningandUSGscanatweeks18to22.Forsymptomaticpregnantwomen,currenttreatmentapproachiscomposedoflopinavir/ritonavirandhydroxychloroquine.Wheretocolyticagentsarerequiredduetoincreasedriskofpretermlabor,nifedipineshouldbepreferredasthetreatmentoffirstchoice.Useofindomethacin,ontheotherhand,isnotrecommendedasitpromotesACE-2expression.
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

ThenumberofindividualsinfectedwithSARS-CoV-2virushasbeenincreasingdaybyday.Overtime,apparently,agrowingnumberofpregnantwomenwillbecomeinfectedwiththisviruswhichleadstothediseaseCovid-19.ThenumberofstudiesisinsufficienttoconcludeontheprognosisofCovid-19duringpregnancy;however,availablestudiessuggestabetterprognosiscomparedtothatofSARSandMERS.Noviruswasfoundinamnioticfluid,vaginalsecretions,cordblood,orplacenta.Existingstudiessuggestanincreasedriskofpretermlabor.Ourprimarygoalshouldbepreventionofcontractingthevirusandtostopitsfurthertransmission,ifcontracted.Hospitalizationisnotindicatedforthosewhoremainasymptomaticbuttheircompliancewiththeisolationprecautionsisparamount.Therehasbeennoconsensusonroutinepregnancyfollow-ups.Obstetriciansshoulddecideonthefollow-upfrequencypayingparticularattentiontotheimportanceoffirsttrimesterscreeningandUSGscanatweeks18to22.Forsymptomaticpregnantwomen,currenttreatmentapproachiscomposedoflopinavir/ritonavirandhydroxychloroquine.Wheretocolyticagentsarerequiredduetoincreasedriskofpretermlabor,nifedipineshouldbepreferredasthetreatmentoffirstchoice.Useofindomethacin,ontheotherhand,isnotrecommendedasitpromotesACE-2expression.

Özet

Covid-19virüsüileenfektekişisayısıhergeçengünartmaktadır.Busüreçteenfektegebesayısınınartacağıaşikardır.Covid-19ilegebelikprognozunhakkındayorumyapmakiçinyeterlisayıdaçalışmaolmamasınarağmenmevcutçalışmalarsonucundaprognozunSARSveMERSvirüslerinegöredahaiyiolduğunudüşünüyoruz.Amniyonsıvısında,vajinalsıvılarda,kordonkanında,plasentadavirüserastlanmamıştır.Yapılançalışmalarsonucundapretermeylemriskininarttığıdüşünülmektedir.Primeramacımızvirüsilekarşılaşmamak,karşılaşmaolmuşisediğerkişilerevirüsübulaştırmamaktır.Asemptomatikvakalarınhastaneyatışendikasyonuyoktur.Fakatizolasyonkurallarınauymalarıönemlidir.Rutintakiplerkonusundafikirbirliğiyoktur.Obstetrisyenözellikle1.trimestrtaramave18.-22.haftaUSGtaramasınınöneminiunutmadantakipsıklığınakararvermelidir.SemptomatikgebelerdeiseLopinavir/RitonavirveHidroksiklorokinşuandakabulgörentedaviyaklaşımıdır.PretermeylemriskininartmasınedeniiletokolitiktedaviverilecekiseilkseçenekolarakNipedipinönerilmektedir.ACE-2ekspresyonunuarttırdığıiçinİndometazinkullanımıönerilmemektedir.Gebeliğinfizyolojikdeğişiklikleriunutulmadanyoğunbakımyatışkriterlerineuygunolaraksolunumdesteğiveaşırısıvıyüklenmesindenkaçınmakoldukçaönemlidir.YoğunbakımtedavisigerekengebelerbaştaolmaküzeretedavisürecindeEnfeksiyonHastalıkları,Perinatoloji,Anestezi,GöğüsHastalıklarıveYenidoğanUzmanıilebirliktemultidisiplineryaklaşımönerilmektedir.

🔖

Cite This Article

SİVASLIOĞLU, A. A., YEĞİN, G. F., KINCI, M. F. (2022). Covid-19 Managementin Pregnancy. Ege Klinikleri Tıp Dergisi, Cilt: 58 - Sayı: 1, 50–54. https://ajindex.com/articles/495646

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. GorbalenyaAE.Severeacuterespiratorysyndrome-relatedcoronavirus–Thespeciesanditsviruses,astatementoftheCoronavirusStudyGroup.BioRxiv.2020.2.HuangC,WangY,LiX,RenL,ZhaoJ,HuY,etal.Clinicalfeaturesofpatientsinfectedwith2019novelcoronavirusinWuhan,China.TheLancet.2020
  2. 395(10223):497-506. 3.NovelCPERE.Theepidemiologicalcharacteristicsofanoutbreakof2019novelcoronavirusdiseases(COVID-19)inChina.Zhonghualiuxingbingxuezazhi=Zhonghualiuxingbingxuezazhi.2020
  3. 41(2):145. 4.ZengJ,HuangJ,PanL.HowtobalanceacutemyocardialinfarctionandCOVID- 19:theprotocolsfromSichuanProvincialPeople’sHospital.Intensivecaremedicine.2020:1- 3. 5.LuR,ZhaoX,LiJ,NiuP,YangB,WuH,etal.Genomiccharacterisationandepidemiologyof2019novelcoronavirus:implicationsforvirusoriginsandreceptorbinding.TheLancet.2020
  4. 395(10224):565-74. 6.ChenY,LiuQ,GuoD.Emergingcoronaviruses:genomestructure,replication,andpathogenesis.Journalofmedicalvirology.2020. 7.WuZ,McGooganJM.Characteristicsofandimportantlessonsfromthecoronavirusdisease2019(COVID-19)outbreakinChina:summaryofareportof72314casesfromtheChineseCenterforDiseaseControlandPrevention.Jama.2020.8.RasmussenSA,SmulianJC,LednickyJA,WenTS,JamiesonDJ.CoronavirusDisease2019(COVID-19)andPregnancy:Whatobstetriciansneedtoknow.Americanjournalofobstetricsandgynecology.2020.9.BAKANLIĞITS.COVID-19(2019-nCoVHASTALIĞI)REHBERİ. 10.BaiY,YaoL,WeiT,TianF,JinD-Y,ChenL,etal.PresumedasymptomaticcarriertransmissionofCOVID-19.Jama.2020. 11.XuZ,ShiL,WangY,ZhangJ,HuangL,ZhangC,etal.PathologicalfindingsofCOVID-19associatedwithacuterespiratorydistresssyndrome.TheLancetrespiratorymedicine.2020. 12.DongE,DuH,GardnerL.Aninteractiveweb-baseddashboardtotrackCOVID-19inrealtime.TheLancetInfectiousDiseases.2020.13.PrompetcharaE,KetloyC,PalagaT.ImmuneresponsesinCOVID-19andpotentialvaccines:LessonslearnedfromSARSandMERSepidemic.AsianPacJAllergyImmunol.2020
  5. ChenW-H,StrychU,HotezPJ,BottazziME.TheSARS-CoV-2VaccinePipeline:anOverview.CurrentTropicalMedicineReports.2020:1-4. 15.DhamaK,SharunK,TiwariR,SircarS,BhatS,MalikYS,etal.Coronavirusdisease2019–COVID-19.2020 16.ChenL,XiongJ,BaoL,ShiY.ConvalescentplasmaasapotentialtherapyforCOVID-19.TheLancetInfectiousDiseases.2020
  6. 20(4):398-400. 17.Soma-PillayP,CatherineN-P,TolppanenH,MebazaaA,TolppanenH,MebazaaA.Physiologicalchangesinpregnancy.CardiovascularjournalofAfrica.2016
  7. 27(2):89. 18.RasmussenSA,JamiesonDJ,BreseeJS.Pandemicinfluenzaandpregnantwomen.Emerginginfectiousdiseases.2008
  8. 14(1):95. 19.WongSF,ChowKM,LeungTN,NgWF,NgTK,ShekCC,etal.Pregnancya