The Relatıonshıp Between Novel Peripheral Blood C ell Ratios And 90 Day Mortality In Patients Wıth Acute Ischemic Stroke Receiving Thrombolitic Therapy
Trombolitik Tedavi Alan Akut İskemik İnmeli Hastalarda Yeni Periferik Kan Hücresi Oranları İle 90 Günlük Mortalite Arasındaki İlişki
Introduction Stroke is the leading cause of neurological morbidity and mortality worldwide İnflammation occurs in the cerebral tissue in acute ischemic stroke ( The aim of this study to evaluate the relationship between short term clinical outcomes and inflammatory biomarkers in AIS patients after intravenous thrombolysis ( Material and Method 126 patients with AIS who received IVT were screened retrospectively Inflammatory parameters such as leukocyte count neutrophil count lymphocyte count neutrophil lymphocyte ratio ( nad platelet lymphocyte ratios ( were recorded before IVT and in the first 24 hours after IVT The primary outcome was good functional improvement Modified Rankin Score MRS 0 2 at three months Sekondary outcomes were symtomatic intracranial hemorrhage ( and three month mortality rate A multivariate analysis was performed to evaluate associations between inflammatory biomarkers and three month clinical outcomes Results:In our study, %51.6 of patients with MRS
📌 3 Key Takeaways
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Objective & Hypothesis:Introduction Stroke is the leading cause of neurological morbidity and mortality worldwide İnflammation occurs in the cerebral tissue in acute ischemic stroke ( The aim of this study to evaluate the relationship between short term clinical outcomes and inflammatory biomarkers in AIS patients after intravenous thrombolysis ( Material and Method 126 patients with AIS who received IVT were screened retrospectively Inflammatory parameters such as leukocyte count neutrophil count lymphocyte count neutrophil lymphocyte ratio ( nad platelet lymphocyte ratios ( were recorded before IVT and in the first 24 hours after IVT The primary outcome was good functional improvement Modified Rankin Score MRS 0 2 at three months Sekondary outcomes were symtomatic intracranial hemorrhage ( and three month mortality rate A multivariate analysis was performed to evaluate associations between inflammatory biomarkers and three month clinical outcomes Results:In our study, %51.6 of patients with MRS
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Key Findings & Data:Introduction Stroke is the leading cause of neurological morbidity and mortality worldwide İnflammation occurs in the cerebral tissue in acute ischemic stroke ( The aim of this study to evaluate the relationship between short term clinical outcomes and inflammatory biomarkers in AIS patients after intravenous thrombolysis ( Material and Method 126 patients with AIS who received IVT were screened retrospectively Inflammatory parameters such as leukocyte count neutrophil count lymphocyte count neutrophil lymphocyte ratio ( nad platelet lymphocyte ratios ( were recorded before IVT and in the first 24 hours after IVT The primary outcome was good functional improvement Modified Rankin Score MRS 0 2 at three months Sekondary outcomes were symtomatic intracranial hemorrhage ( and three month mortality rate A multivariate analysis was performed to evaluate associations between inflammatory biomarkers and three month clinical outcomes Results:In our study, %51.6 of patients with MRS
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Conclusion & Impact:Introduction Stroke is the leading cause of neurological morbidity and mortality worldwide İnflammation occurs in the cerebral tissue in acute ischemic stroke ( The aim of this study to evaluate the relationship between short term clinical outcomes and inflammatory biomarkers in AIS patients after intravenous thrombolysis ( Material and Method 126 patients with AIS who received IVT were screened retrospectively Inflammatory parameters such as leukocyte count neutrophil count lymphocyte count neutrophil lymphocyte ratio ( nad platelet lymphocyte ratios ( were recorded before IVT and in the first 24 hours after IVT The primary outcome was good functional improvement Modified Rankin Score MRS 0 2 at three months Sekondary outcomes were symtomatic intracranial hemorrhage ( and three month mortality rate A multivariate analysis was performed to evaluate associations between inflammatory biomarkers and three month clinical outcomes Results:In our study, %51.6 of patients with MRS
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Introduction Stroke is the leading cause of neurological morbidity and mortality worldwide İnflammation occurs in the cerebral tissue in acute ischemic stroke ( The aim of this study to evaluate the relationship between short term clinical outcomes and inflammatory biomarkers in AIS patients after intravenous thrombolysis ( Material and Method 126 patients with AIS who received IVT were screened retrospectively Inflammatory parameters such as leukocyte count neutrophil count lymphocyte count neutrophil lymphocyte ratio ( nad platelet lymphocyte ratios ( were recorded before IVT and in the first 24 hours after IVT The primary outcome was good functional improvement Modified Rankin Score MRS 0 2 at three months Sekondary outcomes were symtomatic intracranial hemorrhage ( and three month mortality rate A multivariate analysis was performed to evaluate associations between inflammatory biomarkers and three month clinical outcomes Results:In our study, %51.6 of patients with MRS
Özet
Giriş İnme, dünya çapında nörolojik morbidite ve mortalitenin en önemli nedenidir Akut iskemik inmede ( serebral dokuda inflamasyon meydana gelmektedir Bu çalışmanın amacı, intravenöz tromboliz ( sonrası AIS hastalarının kısa dönem klinik sonuçları ile inflamatuar biyobelirteçler arasındaki ilişkiyi değerlendirmektir Gereç ve Yöntem IVT alan AIS 126 hasta retrospektif olarak tarandı Hastalardan IVT öncesi ve IVT’den sonraki ilk 24 saat içerisinde inflamatuvar parametreler olan lökosit sayısı, nötrofil sayısı, lenfosit sayısı, nötrofil lenfosit oranı ( ve trombosit lenfosit oranları ( kaydedildi Birincil sonuç, 3 ayda iyi fonksiyonel iyileşme Modifiye Rankin Skoru ( 0 2 idi İkincil sonuçlar ise semptomatik intrakraniyal hemoraji ( ve 3 aylık mortaliteydi İnflamatuar biyobelirteçler ile 3 aylık klinik sonuçlar arasındaki ilişkileri değerlendirmek için çok değişkenli bir analiz gerçekleştirildi Bulgular Ç alışmamızda MRS< 3 olan hastalar 51 6 ve MRS 3 5 arasında olanlar 38 9 olarak bulundu Hasta popülasyonunda 5 hastada IKH saptanmış olup 12 hasta ex olmuştur İnme risk faktörlerinden en sık hipertansiyon tespit edildi Tüm hastalarda trombosit değerleri dışındaki lökosit, nötrofil lenfosit, NLO ve TLO başlangıç ile 24 saat içindeki laboratuvar değerleri istatistiksel olarak anlamlı bulundu (p˂ 0 05 Sonuç Çalışmamız IVT ile tedavi edilen AIS hastalarında artmış inflamatuar biyobelirteç seviyelerinin 3 ayda kötü sonuçlarla ilişkili olduğunu göstermektedir
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Cite This Article
GÜLLÜPINAR, B., KORAN, S., VAROL, K. N., ÜNAL, G. Ç., ORTAN, P., ÜNLÜER, E. E. (2022). The Relatıonshıp Between Novel Peripheral Blood C ell Ratios And 90 Day Mortality In Patients Wıth Acute Ischemic Stroke Receiving Thrombolitic Therapy. Ege Klinikleri Tıp Dergisi, Cilt: 60 - Sayı: 1, 36–42. https://ajindex.com/articles/495561
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