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Journals / Düzce Üniversitesi Bilim ve Teknoloji Dergisi / 2020 / Cilt: 8 - Sayı: 1

Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases

Asimetrik Schiff Bazı Ni(II) Komplekslerinin Antimutajenik Aktivitesinin Değerlendirilmesi

Dilek NARTOP
Elvan HASANOĞLU ÖZKAN
Hamit Emre KIZIL
Güleray AĞAR
Nurşen SARI
Pages
608–616
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It has been determined that the synthesized compounds have antimutagenic properties and reduce the mutagenicity caused by sodium azide (NaN3) which is used as a positive control.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this work, Ni(II) complexes with unsymmetric Schiff bases (NiL1, NiL2, NiL3, NiL4) were prepared by a two-stage method reported by one of us recently for investigate antimutagenic properties.
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Key Findings & Data:Sodium azide-induced antimutagenic effect in lymphocytes was determined by sister chromatid exchange (SCE) and micronucleus (MN) methods.
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Conclusion & Impact:It has been determined that the synthesized compounds have antimutagenic properties and reduce the mutagenicity caused by sodium azide (NaN3) which is used as a positive control.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Asimetrik diimin · Ni(II) kompleksi · sodyum azit

Abstract

In this work, Ni(II) complexes with unsymmetric Schiff bases (NiL1, NiL2, NiL3, NiL4) were prepared by a two-stage method reported by one of us recently for investigate antimutagenic properties. Sodium azide-induced antimutagenic effect in lymphocytes was determined by sister chromatid exchange (SCE) and micronucleus (MN) methods. It has been determined that the synthesized compounds have antimutagenic properties and reduce the mutagenicity caused by sodium azide (NaN3) which is used as a positive control.

Özet

Bu çalışmada, asimetrik Ni(II) kompleksleri (NiL1, NiL2, NiL3, NiL4) potansiyel antimutajen özelliklerini incelemek için son zamanlarda grubumuzdan biri tarafından rapor edilen yeni iki aşamalı bir yöntem ile hazırlandı. Lenfositlerdeki sodyum azid kaynaklı antimutagenik etki, kardeş kromatid değişimi (SCE) ve mikronükleus (MN) yöntemleriyle belirlendi. Sentezlenen bileşiklerin antimutagenik özelliklere sahip olduğu ve pozitif kontrol olarak kullanılan sodyum azid (NaN3)'ün neden olduğu mutajeniteyi azalttıkları belirlenmiştir.

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Cite This Article

NARTOP, D., ÖZKAN, E. H., KIZIL, H. E., AĞAR, G., SARI, N. (2022). Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases. Düzce Üniversitesi Bilim ve Teknoloji Dergisi, Cilt: 8 - Sayı: 1, 608–616. https://ajindex.com/articles/494241

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