Journals / Dicle Üniversitesi Veteriner Fakültesi Dergisi / 2020 / Cilt: 13 - Sayı: 2

Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas

Köpek Meme Karsinomlarında PCNA ve MMP-9 Ekspresyonlarının İmmunohistokimyasal Olarak Değerlendirilmesi

Pages
119–124
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, there may be a positive relationship between cell proliferation, invasion andmetastasis capacity under the solid subtype.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to evaluate reveal whether there is a significant relationship between cell proliferation and invasion-metastasiscapacity in various mammary carcinomas subtypes observed in dogs immunohistochemically with PCNA and MMP-9 markers.
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Key Findings & Data:Thematerial of this study consisted of tissue samples of mammary carcinomas taken from 6 Kangal and 4 Setter dogs with an average age of8.4 years brought to our department between 2012 and 2020. 4 of 10 mammary carcinoma cases were classified as intraductal papillarycarcinoma, 4 as carcinoma mixed, 1 as solid carcinoma and 1 as tubular carcinoma.
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Conclusion & Impact:In conclusion, there may be a positive relationship between cell proliferation, invasion andmetastasis capacity under the solid subtype.
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

The aim of this study was to evaluate reveal whether there is a significant relationship between cell proliferation and invasion-metastasiscapacity in various mammary carcinomas subtypes observed in dogs immunohistochemically with PCNA and MMP-9 markers. Thematerial of this study consisted of tissue samples of mammary carcinomas taken from 6 Kangal and 4 Setter dogs with an average age of8.4 years brought to our department between 2012 and 2020. 4 of 10 mammary carcinoma cases were classified as intraductal papillarycarcinoma, 4 as carcinoma mixed, 1 as solid carcinoma and 1 as tubular carcinoma. We found the highest mean number of PCNA andMMP-9 positive cells in solid subtype. In conclusion, there may be a positive relationship between cell proliferation, invasion andmetastasis capacity under the solid subtype.

Özet

Bu çalışmanın amacı, köpeklerde görülen çeşitli meme karsinomu alt tiplerinde hücre proliferasyonu ile invazyon-metastaz kapasitesi arasında anlamlı bir ilişki olup olmadığını PCNA ve MMP-9 gibi immunohistokimyasal belirteçler aracılığıyla ortaya koymaktır. Bu çalışmanın materyali, 2012-2020 yılları arasında anabilim dalımıza getirilen yaş ortalaması 8,4 yıl olan 6 Kangal ve 4 Setter köpeğinden alınan meme kanseri doku örnekleri oluşturdu. 10 meme karsinomu vakasından 4'ü intraduktal papiller karsinom, 4'ü miks karsinom, 1'i solid karsinom ve 1'i tübüler karsinom olarak sınıflandırıldı. Solid alt tipte en yüksek ortalamada PCNA ve MMP-9 pozitif hücre sayısı bulundu. Sonuç olarak sadece solid alt tipte hücre proliferasyonu ile invazyon ve metastaz kapasitesi arasında pozitif bir ilişki olabileceği kanısına varıldı.

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Cite This Article

ORAL, H., KURU, M., KARAKURT, E., DAĞ, S., YILDIZ, A., NUHOĞLU, H., BEYTUT, E. (2022). Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas. Dicle Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 13 - Sayı: 2, 119–124. https://ajindex.com/articles/488161

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