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Journals / Mellifera / 2020 / Cilt: 20 - Sayı: 1

Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats

Züleyha DOĞANYİĞİT
Emin KAYMAK
Aslı OKAN
Dilek PANDIR
Sibel SİLİCİ
Journal
Mellifera
Pages
3–15
Publication Date
2020-06-29
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found that the lung samples of LPS + 0,4 and LPS + 0,8 API groups decreased statistically significant compared to the LPS group.

📌 3 Key Takeaways

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Objective & Hypothesis:Apilarnil is a bee product that has attracted attention due to its beneficial biological properties recently.
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Key Findings & Data:For the study, 64 adult male Sprague dawley rats were divided into eight groups; control, 0.2, 0.4 and 0.8 g / kg API treated groups by gavage for 10 days, 30 mg / kg lipopolysaccharide (LPS) administered intraperitoneally (single dose), LPS + 0.2, LPS + 0.4 and LPS + 0.8 g / kg API applied groups.
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Conclusion & Impact:It was found that the lung samples of LPS + 0,4 and LPS + 0,8 API groups decreased statistically significant compared to the LPS group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Apilarnil · LPS · TUNEL method

Abstract

Apilarnil is a bee product that has attracted attention due to its beneficial biological properties recently. This study aimed to investigate the effect of apilarnil (API) on endotoxin-induced lung injury. For the study, 64 adult male Sprague dawley rats were divided into eight groups; control, 0.2, 0.4 and 0.8 g / kg API treated groups by gavage for 10 days, 30 mg / kg lipopolysaccharide (LPS) administered intraperitoneally (single dose), LPS + 0.2, LPS + 0.4 and LPS + 0.8 g / kg API applied groups. In histopathological evaluation, hyperemia, intra-alveolar hemorrhage, cellular infiltration, and increased cellular abnormal proliferation were observed in the lung samples of the LPS group. It was found that the lung samples of LPS + 0,4 and LPS + 0,8 API groups decreased statistically significant compared to the LPS group. The number of TUNEL positive cells observed in both LPS and API treated groups showed a statistically significant decrease compared to the LPS group. In comet test, 0,8 API group was found to be reduced more in tail % DNA and tail length when LPS + API treated groups were compared with LPS group. In conclusion, the API applied to rats can prevent LPS-induced lung injury.

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Cite This Article

DOĞANYİĞİT, Z., KAYMAK, E., OKAN, A., PANDIR, D., SİLİCİ, S. (2020). Investigation of Protective Effects of Apilarnil Against Lipopolysaccharide Induced Lung Injury in Rats. Mellifera, Cilt: 20 - Sayı: 1, 3–15. https://ajindex.com/articles/48806

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