Does changes in trace elements levels explain tissue hypoxia?

According to these results, levels of trace elements and oxidative stress were more important than viscosity in hypoxia distal to atherosclerotic arteriel occlusion.

📌 3 Key Takeaways

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Objective & Hypothesis:Plasma lipid peroxidation, iron (Fe), zinc (Zn), copper (Cu) levels, viscosity and erythrocyte membrane deformibility (EMD) were measured in blood samples taken from 25 patients with peripheral vascular disease and 25 healthy individuals, to investigate the roles of lipid peroxidation and trace elements in chronic ischemia.

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Key Findings & Data:In group with peripheral vascular disease, Fe, Cu and lipid peroxidation levels were found high, in contrast to low levels of Zn, viscosity and EMD.

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Conclusion & Impact:According to these results, levels of trace elements and oxidative stress were more important than viscosity in hypoxia distal to atherosclerotic arteriel occlusion.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Plasma lipid peroxidation, iron (Fe), zinc (Zn), copper (Cu) levels, viscosity and erythrocyte membrane deformibility (EMD) were measured in blood samples taken from 25 patients with peripheral vascular disease and 25 healthy individuals, to investigate the roles of lipid peroxidation and trace elements in chronic ischemia. In group with peripheral vascular disease, Fe, Cu and lipid peroxidation levels were found high, in contrast to low levels of Zn, viscosity and EMD. The differences were stastistically meaningful. According to these results, levels of trace elements and oxidative stress were more important than viscosity in hypoxia distal to atherosclerotic arteriel occlusion.

Özet

Lipid peroksidasyonu ve eser elementlerin kronik iskemide rollerini araştırmak amacıyla, 25 periferik damar hastasından ve damar hastalığı bulunmayan 25 bireyden alınan kan örneklerinde plazma lipid peroksidasyonu, demir (Fe), çinko (Zn), bakır (Cu) seviyeleri, viskosite ve eritrosit membran deformibilitesi (EMD) ölçüldü. Periferik arter hasta gurubunda Fe, Cu ve lipid peroksidasyon düzeyleri istatistiksel anlamlı yüksek, Zn düzeyi, viskosite ve EMD değerleri düşük bulundu. Bu sonuçlara göre, aterosklerotik tıkanıklığın distalindeki doku hipoksisinde, eser element düzeylerinin ve oksidatif stresin, viskositeden daha önemli etkenler olduğu anlaşılmaktadır.

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Cite This Article

KÖKSAL, C., BOZKURT, K., ARSLAN, C., KAZIMOĞLU, K., SAYIN, A. G., ERCAN, M., KONUKOĞLU, D. (2022). Does changes in trace elements levels explain tissue hypoxia?. Damar Cerrahi Dergisi, Cilt: 10 - Sayı: 1, 19–22. https://ajindex.com/articles/486906

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