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Journals / Damar Cerrahi Dergisi / 2006 / Cilt: 15 - Sayı: 2

The effects of nebivolol on intimal hyperplasia following endothelial injury: An experimental study

Endotel hasarı sonrası oluşan intimal hiperplazi üzerine nebivololün etkisi: Deneysel çalışma

İlker AKAR
Mehmet BALİN
Erdoğan İLKAY
Oktay BURMA
Ayhan UYSAL
Bilal ÜSTÜNDAĞ
İbrahim Hanifi ÖZERCAN
Ali RAHMAN
Pages
23–31
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The neointimal thickening was significantly less in nebivolol group than in control and solvent group (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Pupose: Intimal hyperplasia is a vascular remodelling process.
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Key Findings & Data:Methods: The study was made on 21 rabbits which were equally divided into 3 groups.
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Conclusion & Impact:The neointimal thickening was significantly less in nebivolol group than in control and solvent group (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Pupose: Intimal hyperplasia is a vascular remodelling process. It is a clinical problem which forms in vascular wall as a result of smooth muscle cell migration, proliferation and extracellular matrix accumulation. In this study we examined the effects of nebivolol on intimal hyperplasia at denadue endothelial tissue. Methods: The study was made on 21 rabbits which were equally divided into 3 groups. Control, solvent and nebivolol. The rabbits in control group only underwent balloon injury on abdominal aorta. The rabbits in solvent group and nebivolol group underwent balloon injury and were treated with solvent and nebivolol intraperitoneally during the study. At the end of the study, abdominal aortas were harvested. Intimal, medial areas were measured and intima/media ratios were calculated. Tissue nitric oxide levels were detected. Results: Statistically there were no differences between control and solvent groups at intimal, medial areas, intima/media ratios and tissue NO levels. The neointimal thickening was significantly less in nebivolol group than in control and solvent group (p

Özet

Amaç: İntimal hiperplazi vasküler remodeling süreci olup vasküler duvarda düz kas hücre migrasyonu ve proliferasyonu ile ekstrasellüler matriks birikimi sonucu oluşan klinik bir problemdir. Bu çalışmada; nebivololün hasarlanmış endotel dokusunda intimal hiperplazi gelişimine etkilerini araştırdık. Yöntem: Çalışma eşit 3 gruba ayrılan toplam 21 tavşanda gerçekleştirildi: Kontrol, solvent ve nebivolol grupları. Kontrol grubundaki tavşanların abdominal aortalarına sadece balon ile endotel hasarı uygulandı. Solvent ve nebivolol grubundaki tavşanlara ise balon hasarı uygulanmasının dışında işlem öncesi 2 gün ve sonrası 28 gün süresince intraperitoneal olarak solvent ve nebivolol verildi. Tüm gruplarda 28. günde alınan abdominal aort kesitlerinde intimal-medial alanları ölçülerek her bir kesitteki intima/media oranları elde edildi. Ayrıca biyokimyasal olarak doku NO düzeyleri ölçüldü. Bulgular: Kontrol ve solvent grupları arasında intimal, medial alanlar ile intima/media oranları ve doku NO düzeyleri yönünden anlamlı fark bulunmadı. İntimal alan artışı nebivolol grubunda kontrol ve solvent gruplarına göre anlamlı derecede az iken (p

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Cite This Article

AKAR, İ., BALİN, M., İLKAY, E., BURMA, O., UYSAL, A., ÜSTÜNDAĞ, B., ÖZERCAN, İ. H., RAHMAN, A. (2022). The effects of nebivolol on intimal hyperplasia following endothelial injury: An experimental study. Damar Cerrahi Dergisi, Cilt: 15 - Sayı: 2, 23–31. https://ajindex.com/articles/486845

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