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Journals / Damar Cerrahi Dergisi / 2014 / Cilt: 23 - Sayı: 1

Effect of ıloprost and levosimendan on renal ınjury ınduced by acute lower extremity ıschemia-reperfusion

Akut alt ekstremite iskemi reperfüzyon sonrasında gelişen böbrek hasarına iloprost ve levosimendanın etkilerinin araştırılması

Seyhan BABAROĞLU
Mustafa SEREN
Atalay KARAKAYA
Recep ASLAN
Fatih YILMAZ
Kanat ÖZIŞIK
Orçun ÜNAL
Emine DÜNDAR
Pages
34–39
Publication Date
2022-10-10
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In IR+IL group and in Group IR+LV group tubular necrosis, hydropic degeneration, neutrophilic infiltration, edema and congestion were statistically non-significant.Conclusion: The histological analyses have revealed that iloprost and levosimendan have no protective effect against reperfusion injury in rat kidney.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, we investigated the effects of iloprost and levosimendan in ischemia-reperfusion injury after infrarenal abdominal aorta occlusion in rats.Material and Methods: Thirty two adult female Sprague-Dawley rats were randomly divided in to 4 groups.
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Key Findings & Data:In Group IR, ischemia was produced for 60 minutes and then they were reperfused for 120 minutes.
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Conclusion & Impact:In IR+IL group and in Group IR+LV group tubular necrosis, hydropic degeneration, neutrophilic infiltration, edema and congestion were statistically non-significant.Conclusion: The histological analyses have revealed that iloprost and levosimendan have no protective effect against reperfusion injury in rat kidney.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, we investigated the effects of iloprost and levosimendan in ischemia-reperfusion injury after infrarenal abdominal aorta occlusion in rats.Material and Methods: Thirty two adult female Sprague-Dawley rats were randomly divided in to 4 groups. Group K was the control group. In Group IR, ischemia was produced for 60 minutes and then they were reperfused for 120 minutes. In Group IR+IL, 20 ng/kg/min iloprost, and in Group IR+LV 0.2 µg/kg/min levosimendan were given 15 minutes before reperfusion. Renal samples were put into formaldehyde solution and were histologically examined under the light microscope.Results: Histopathological investigations showed no pathologic damage in the control and ischemia groups. In IR+IL group and in Group IR+LV group tubular necrosis, hydropic degeneration, neutrophilic infiltration, edema and congestion were statistically non-significant.Conclusion: The histological analyses have revealed that iloprost and levosimendan have no protective effect against reperfusion injury in rat kidney.

Özet

Amaç: Bu çalışmada sıçan infrarenal abdominal aortasında oklüzyon-reperfüzyon sonrası, böbreklerde oluşan iskemi-reperfüzyon hasarına iloprost ve levosimendanın etkileri araştırılmıştır.Gereç ve Yöntemler: Otuz iki adet Sprague-Dawley cinsi dişi sıçan randomize olarak, eşit sayıda (n=8) dört gruba ayrıldı. Grup K kontrol grubu idi. Grup IRde 60 dakika iskemi oluşturuldu, daha sonra 120 dakika reperfüze edildi. Grup IR+IL ve grup IR+LVde reperfüzyondan 15 dakika önce sırası ile 20 ng/kg/dk iloprost, 0,2 µg/kg/dk levosimendan infüzyonu verildi. Ratlardan alınan böbrek doku örnekleri formaldehit fiksasyonu sonrası ışık mikroskobunda histolojik olarak değerlendirildi.Bulgular: Histopatolojik incelemede, K grubu ile IR grubunda anlamlı patolojik değişiklik tespit edilmedi. IR+IL ve IR+LV gruplarında bulanık şişme, tübüler nekroz, iltihabi hücre infiltrasyonu, ödem ve konjesyon, istatistiksel olarak anlamlı bulunmadı.Sonuç: Histolojik analizler iloprost ve levosimendanın reperfüzyon hasarı oluşan rat böbrekleri üzerinde koruyucu etkileri olduğunu göstermemiştir.

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Cite This Article

BABAROĞLU, S., SEREN, M., KARAKAYA, A., ASLAN, R., YILMAZ, F., ÖZIŞIK, K., ÜNAL, O., DÜNDAR, E. (2022). Effect of ıloprost and levosimendan on renal ınjury ınduced by acute lower extremity ıschemia-reperfusion. Damar Cerrahi Dergisi, Cilt: 23 - Sayı: 1, 34–39. https://ajindex.com/articles/486745

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