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Journals / Çukurova Üniversitesi Tıp Fakültesi Dergisi / 1996 / Cilt: 21 - Sayı: 1

Acute and short-term effects of nicardipine on cardiovascular system in essential hypertension

Esansiyel hipertansiyonda nicardipine'in kardiyovasküler sistem üzerine akut ve kısa dönem etkileri

Ahmet IŞIK
A. İhsan GÜNAL
Harika ÇELEBİ
Cemal LÜLECİ
Şafak YÜKSEL
H. Cahit ELMACI
Pages
47–58
Publication Date
2022-10-10
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Aort systolic and transmitral flows were evaluated with continious Doppler.During acute dose phase, nicardipine decreased TPVR by 21% (p

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, the acute (single dose) and the short-term (12 weeks) cardiovascular effects of nicardipine in 34 and 14 cases with essentially hypertensive respectively were evaluated.Heart rate, systolic and diastolic blood pressures (SBP, DBP) were measured at baseline, peak effect time, and on the 2nd, 4th, 8th, 12th weeks respectively.
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Key Findings & Data:The mean blood pressure (MBP), stroke volume (SV), cardiac output (CO), total peripheral vascular resistance (TPVR) and large artery distansibility (LAD) were calculated.
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Conclusion & Impact:Aort systolic and transmitral flows were evaluated with continious Doppler.During acute dose phase, nicardipine decreased TPVR by 21% (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, the acute (single dose) and the short-term (12 weeks) cardiovascular effects of nicardipine in 34 and 14 cases with essentially hypertensive respectively were evaluated.Heart rate, systolic and diastolic blood pressures (SBP, DBP) were measured at baseline, peak effect time, and on the 2nd, 4th, 8th, 12th weeks respectively. The mean blood pressure (MBP), stroke volume (SV), cardiac output (CO), total peripheral vascular resistance (TPVR) and large artery distansibility (LAD) were calculated. Aort systolic and transmitral flows were evaluated with continious Doppler.During acute dose phase, nicardipine decreased TPVR by 21% (p

Özet

Çalışmamızda, dihydropyridine türevi nicardipine'in esansiyel hipertansiyonlu 34 olguda akut (tek doz) ve 14 olguda kısa dönem (12 hafta) kardiyovasküler etkileri incelendi. İlaç uygulaması öncesi, ilacın zirve etki dönemi, kısa dönem ilaç uygulamasının 2, 4, 8 ve 12. haftalarında nabız, sistolik ve diyastolik kan basınçları (SKB, DKB) ölçüldü. Ortalama kan basıncı (OKB), atım hacmi, dakika hacmi, total periferik vasküler direnç (TPVR) ve büyük arter distansibilitesi (BAD) hesaplandı. Kontinü Doppler ile aort sistolik akım ve transmitral akım örnekleri değerlendirildi. Akut doz fazında nicardipine'in hem küçük, hem de büyük arterler üzerinde aynı anda etki göstererek TPVR'ı (% 21, p

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Cite This Article

IŞIK, A., GÜNAL, A. İ., ÇELEBİ, H., LÜLECİ, C., YÜKSEL, Ş., ELMACI, H. C. (2022). Acute and short-term effects of nicardipine on cardiovascular system in essential hypertension. Çukurova Üniversitesi Tıp Fakültesi Dergisi, Cilt: 21 - Sayı: 1, 47–58. https://ajindex.com/articles/486331

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