AI Summary & Key Takeaways
AI InsightAs a conclusion, it can be said that RRT may be a proper choice of treatment in patients with KPS>70 and who were not required an obligatory palliation.
📌 3 Key Takeaways
Abstract
Our Inoperable Locally Advanced (Stage IIIA.B) Non-Small Cell Lung Cancer Patients: Results of Short-Term Low-Dose or Long-Term High-Dose Radiotherapy Administration. In this study, 71 patients with inoperable non-small cell lung cancer (INSCLC) given radiotherapy (RT) in our clinic from 1990 through 1995 were retrospectively analysed. In these patients who had not the requirement of immediate or obligatory palliation, selection of RT dose was prqspectively done only according to "Karnofsky Performance Score" (KPS): 33 patients who had KPS70 treated with high-dose radical (R) RT. In statistical analyses, there were no statistically significant difference and correlation between these two treatment groups according to age, sex and histological grade (p>0.05). While100% of patients in the PRT group was stage NIB, 63% of patients was stage IIIA and 37% was stage IIIB in the RRT group (p=0.00000). Treatment response and median survival were significantly higher in the RRT group than PRT group (13% and 11 months versus 3% and 8 months, p=0.00099 and p=0.001). However it was observed that the survival difference between these groups was come to the same level upto the 3rd year. . As a conclusion, it can be said that RRT may be a proper choice of treatment in patients with KPS>70 and who were not required an obligatory palliation.
Özet
Bu çalışmada, kliniğimizde, 1990-1995 yılları arasında eksternal radyoterapi (RT) verilen, 71 İnopere, lokal ileri, küçük hücreli dışı akciğer kanseri (KHDAK) olgusu retrospektif olarak incelenmiştir. Acil veya zorunlu palyasyon gerekmeyen bu olgularda, RT doz seçimi, prospektif olarak, sadece "Karnofsky Performance Score" (KPS)'una göre yapılmıştır: KPS70 olan 38'ine yüksek doz radikal (R) RT uygulanmıştır. İstatistik! analizlerde, iki tedavi grubu arasında yaş, cinsiyet, histolojik diferansiyasyon derecesine göre anlamlı fark ve korelasyon bulunamamıştır (p>0.05). PRT grubunun %100'ü EIIIB iken, RRT grubunun %63'ü EIIIA, %37'si EIIIB bulunmuştur (p=0.00000). Tedavi cevabı ve median sağ kalım, RRT grubunda anlamlı olarak yüksek çıkmıştır (%13 ve 11 aya karşı %3 ve 8 ay, p=0.00099 ve p=0.001). Ancak gruplar arasındaki bu sağ kalım farkının 3. yılda eşitlendiği gözlenmiştir. Sonuç olarak KPS>70 olan ve zorunlu palyasyonu gerekmeyen olgularımızda, RRT'nin uygun bir tedavi seçeneği olabileceği anlaşılmıştır.