Journals / Çukurova Üniversitesi Tıp Fakültesi Dergisi / 2013 / Cilt: 38 - Sayı: 4

Kömür Tozu Solunması ve Sigaranın Hematobiokimyasal Parametreler Üzerine Etkisi

Effects of Combined Inhalation of Coal Dust and Cigarette Smoking on Haematobiochemical Parameters

Pages
547–552
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Beside that, this exposure also induces an acute phase process of inflammation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: The aim of this study is to determine the effect of inhaled particulate matter coal dust and smoking on the haematobiochemical profile of worker in coal analysis laboratory.
📊
Key Findings & Data:Material and Methods: Twenty nine workers, were randomly divided into three groups, one control group (n=5), one group who exposed to coal dust but non smoking (CDNS) (n=15), and one group exposed to coal dust and smoking (CDS) (n=9).
💡
Conclusion & Impact:Beside that, this exposure also induces an acute phase process of inflammation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: The aim of this study is to determine the effect of inhaled particulate matter coal dust and smoking on the haematobiochemical profile of worker in coal analysis laboratory. Material and Methods: Twenty nine workers, were randomly divided into three groups, one control group (n=5), one group who exposed to coal dust but non smoking (CDNS) (n=15), and one group exposed to coal dust and smoking (CDS) (n=9). The control group included subjects working in administrative division which none have been exposed to coal dust. Exposed group working on coal dust material analysis were divided as smokers and non smokers. The duration of their work period were less than 10 years. Results: Mean of eosinophil and monocytes counts were significantly lower in both of coal dust exposure compared to control group (p < 0.05). Segmental neutrophil counts were significant higher in coal dust exposure group with or without smoking compared to control group (p < 0.05). The level of erythocytre sedimentation rate (ESR) was significantly lower in CDNS group compared to control group (p < 0.05). Conclusion: Combined inhalation of coal dust and cigarette smoking changes cellular immune system such as decreasing of eosinophil and monocytes counts also increasing of segmental neutrophil. Beside that, this exposure also induces an acute phase process of inflammation.

Özet

Amaç: Bu çalışmanın amacı, solunan kömür tozu partiküllerinin ve sigaranın, kömür analiz labaratuvarlarında çalışan işçilerin hematibiokimyasal profilleri üzerindeki etkisini saptamaktır. Materyal ve Metod: 29 işçi rastgele biçimde; kontrol (n=5),kömür tozuna maruz kalmış ancak sigara içmeyen (CDNS) (n=15) ve kömür tozuna maruz kalmış ve sigara içen (CDS) (n=9) olmak üzere üç gruba ayrılmıştır. Kontrol grubundaki bireyler idare ile ilgili birimde çalışan ve kömür tozuna maruz kalmayan bireylerden oluşmaktadır. Maruziyet grubundaki bireyler kömür tozu materyali ile çalışan bireyler olup sigara içen ve içmeyen olarak 2 gruba ayrılmıştır. Bireylerin kurumdaki çalışma süresi 10 yıldan azdır. Bulgular: Eozinofil ve monosit sayıları kontrol grupla karşılaştırıldığında kömür tozuna maruz kalan her 2 grupta da anlamlı şekilde azalmıştır (p < 0.05) . Segmental nötrofil sayıları kontrol grupla karşılaştırıldığında kömür tozuna maruz kalan her 2 grupta da anlamlı olarak artmıştır (p < 0.05). Eritrosit sedimentasyon oranı (ESR), kömür tozuna maruz kalmış ancak sigara içmeyen (CDNS) grupta kontrol grubuna göre anlamlı derecede azalmıştır (p < 0.05). Sonuç: Kömür Tozu solunması ile birlikte sigara içilmesi, eozinofil ve monosit sayısını azaltırken, segmental nötrofillerin sayısının artması gibi hücresel immün sistem mekanizmalarını değiştirmektedir. Bunun yanında bu maruziyet inflamasyonun akut fazınıda indüklemektedir.

🔖

Cite This Article

SETİAWAN, B., KANİA, N., WİDJAJANTO, E., WİDODO, M. A., SUMİTRO, S. B., KUSUMA, H. C. (2022). Kömür Tozu Solunması ve Sigaranın Hematobiokimyasal Parametreler Üzerine Etkisi. Çukurova Üniversitesi Tıp Fakültesi Dergisi, Cilt: 38 - Sayı: 4, 547–552. https://ajindex.com/articles/485982

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Pinho RA, Silveira, PCL, Silva, LA, Steck EL, DalPizzol F, Moreira JCF. N-acetylsisteine and deferoxamine reduce pulmonary oxidative stress and inflammation in rats after coal dust exposure. Environ Res. 2005; 99:355-60
  2. Hendryx M, Zullig KJ. Higher coronary artery disease and heart attack morbidity in Appalachian coal mining regions. Prevent Med. 2009; 49:355-9
  3. Zhang Q, Dai J, Ali A, Chen L, Huang X. Roles of bioavailable iron and calcium in coal dust-induced oxidative stress: Possible implications in coal workers' lung disease. Free Rad Res. 2002; 36285- 294
  4. Zhang Q, Huang X. (2002). Induction of ferritin and lipid peroxidation by coal samples with different prevalence of coal workers' pneumoconiosis: role of iron in the coals. Am J Ind Med. 2002; 42:171-9
  5. Armutcu, F., Gun. B.D., Altin, R., Gurel, A. (2007). Examination of lung toxicity, oxidant/antioxidant status and effect of erdosteine in rats kept in coal mine ambience. Environ Toxicol Pharmacol. 2007; 24:106-13
  6. Junior SA, Possamai FP, Budni P, Backes P, Parisotto EB, Rizelio VM. Occupational airborne contamination in South Brazil: oxidative stress detected in blood of coal miners. Ecotoxicol. 2009; 18:1150-57
  7. Ulker OC, Yucesoy B, Demir O, Tekin IO, Karakaya A. Serum and BAL cytokine and antioxidant enzyme level at different stages of pneumoconiosis in coal workers. Human Exp Toxicol. 2008; 27:871-7
  8. Donaldson K, Brown GM, Brown DM, Robertson MD, Slight J, Cowie H, Jones AD, Bolton RE, Davis JM. Contrasting bronchoalveolar leukocyte responses in rats inhaling coal mine dust, quartz, or titanium dioxide: effects of coal rank, airborne mass concentration, and cessation of exposure. Environ Res. 1990; 52:62-76
  9. Kung MH, Yukata K, O'Keefe RJ. Zuscik MJ. Aryl hydrocarbon receptor-mediated impairmentof chondrogenesis and fracture healing by cigarette smoke and benzo(?)pyrene. J Cell Physiol. 2012; 227:1062-70
  10. Noor Z, Setiawan B. Combined inhalation of cigarette smoke and particulate matter 10 increase bone iron level in rat. J Exp Integr Med. 2013; 3:69- 72
  11. Otitoloju AA, Osunkalu VO, Oduware R, Obe IA, Adewale AO. Haematological effects of radiofrequency radiation from GSM base stations on four succesive generations (F1-F4) of albino mice, Mus musculus. J Environ Occup Sci. 2012; 1:17-22
  12. Jabit M, Wahyuni FS, Khalid R, Israf DA, Shaari K, Lajis NH, Stanslas J. Cytotoxic and nitric oxide inhibitory activities of methanolic extract of garcinia species. Pharm Biol