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Journals / Dicle Tıp Dergisi / 2011 / Cilt: 38 - Sayı: 4

In-vitro susceptibility of methicillin-resistant Staphylococcus aureus strains to antibiotics

İsmail GÜLER
Hüseyin KILIÇ
M. Altay ATALAY
Duygu PERÇİN
Barış Derya ERÇAL
Pages
466–470
Publication Date
2011-12-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Key words: Antibiotic resistance, Staphylococcus au­reus, methicillin-resistance

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Methicillin resistance of S.aureus strains sourced from hospitals and community-acquired has been increasing.
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Key Findings & Data:The aim of this cross-sectional study is to determine the resistance rates to alternative antibiotics of meticilline resistant S.aureus (MRSA) strains, where the multiple resistances are encountered the most.
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Conclusion & Impact:Key words: Antibiotic resistance, Staphylococcus au­reus, methicillin-resistance
🔬Design:Research Article
📍Scope:2008 Verileri
⚙️Variables:antibiyotik direnci · Staphylococcus aureus · metisilin direnci

Abstract

Objectives: Methicillin resistance of S.aureus strains sourced from hospitals and community-acquired has been increasing. The aim of this cross-sectional study is to determine the resistance rates to alternative antibiotics of meticilline resistant S.aureus (MRSA) strains, where the multiple resistances are encountered the most. Materials and methods: A total of 100 MRSA strains iso­lated consequently from the clinical samples of hospital­ized patients in Erciyes University Medical Faculty Hos­pitals between September 2008 and October 2009 were included in the study. According to “Clinical and Labora­tory Standards Institude (CLSI)” criteria, antimicrobial susceptibility testing was performed by Kirby-Bauer disk diffusion method. Results: The rates of resistance to antibiotics of the MRSA strains included within the study were 77% to erythromy­cin, 1% to trimethoprim/sulfamethoxazole (TMP-SXT), 90% to rifampin, 63% clindamycin, 84% to gentamicin and 0% to teicoplanin and vancomycin. Conclusion: All MRSA strains were susceptible to van­comycine and teicoplanin. On the other hand, TMP-SXT seems to be alternative agent for treatment of MRSA in­fections. Key words: Antibiotic resistance, Staphylococcus au­reus, methicillin-resistance

Özet

Amaç: Hastane ve toplum kaynaklı S.aureus suşların­da görülen metisilin direnci ülkemizde giderek artmakta­dır. Bu kesitsel çalışmada, çoklu direnç probleminin en çok yaşandığı metisilin rezistan Staphylococcus aureus (MRSA) suşlarının alternatif antibiyotiklere direnç oranları saptanarak direnç sorununun belirlenmesi. Gereç ve yöntem: Eylül 2008 ile Ekim 2009 tarihleri ara­sında Erciyes Üniversitesi Tıp Fakültesi Hastaneleri\'nde yatmakta olan hastaların klinik örneklerinden ardışık ola­rak izole edilen toplam 100 MRSA suşu çalışmaya alındı. Antimikrobiyal duyarlılıkları “Clinical and Laboratory Stan­dards Institute (CLSI)” önerileri doğrultusunda Kirby-Bau­er disk difüzyon yöntemi kullanılarak değerlendirildi. Bulgular: Çalışma kapsamına alınan MRSA suşlarının antibiyotiklere direnç oranları sırasıyla; eritromisin %77, trimetoprim/sülfametoksazol (TMP-SXT) %1, rifampisin %90, klindamisin %63, gentamisin %84, teikoplanin ve vankomisin için ise %0 olarak belirlendi. Sonuç: Tüm MRSA suşları vankomisin ve teikoplanine duyarlı bulunmuştur. Diğer taraftan, TMP-SXT MRSA te­davisinde alternatif ajan olarak görünmektedir.

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Cite This Article

GÜLER, İ., KILIÇ, H., ATALAY, M. A., PERÇİN, D., ERÇAL, B. D. (2011). In-vitro susceptibility of methicillin-resistant Staphylococcus aureus strains to antibiotics. Dicle Tıp Dergisi, Cilt: 38 - Sayı: 4, 466–470. https://ajindex.com/articles/485431

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