SavedAdd your journal

Journals / Dicle Tıp Dergisi / 2018 / Cilt: 45 - Sayı: 2

Association of signal transducer and activator of transcription, interleukin-6, and interleukin-10 positivity with antiviral treatment in cirrhotic liver samples from patients with the hepatitis B or C virus

Hepatit B ve Hepatit C Nedenli Sirotik Karaciğer Metaryalinde Sinyal transdüserleri ve transkripsiyon aktivatörleri, İnterlökin-6, İnterlökin-10 Pozitifliğinin Antiviral Tedavi ile İlişkisi

Faik TATLI
Saime Hale KIRIMLIOĞLU
Sezai YILMAZ
Orhan GÖZENELİ
Cüneyt KAYAALP
Melih KARINCAOĞLU
Abuzer DİRİCAN
Bora BARUT
Vedat KIRIMLIOĞLU
Pages
187–194
Publication Date
2018-06-15
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this regard, lamivudine was the most effective drug in the present study.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Terminal liver disease due to viral hepatitis infections is an important health problem.
📊
Key Findings & Data:This study aimed to compare the expression of members of the signal transducer and activator of transcription (STAT) family (STAT-1, -2, -3, -5a, and -5b) and interleukin (IL)-6 and IL-10 in hepatectomy material from patients who received antiviral treatment and underwent a liver transplantation due to terminal liver failure.
💡
Conclusion & Impact:In this regard, lamivudine was the most effective drug in the present study.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:STAT family · IL-6/ IL-10 · nucleoside analogs

Abstract

Objective: Terminal liver disease due to viral hepatitis infections is an important health problem. This study aimed to compare the expression of members of the signal transducer and activator of transcription (STAT) family (STAT-1, -2, -3, -5a, and -5b) and interleukin (IL)-6 and IL-10 in hepatectomy material from patients who received antiviral treatment and underwent a liver transplantation due to terminal liver failure. Methods: The study consisted of 45 patients who underwent a liver transplantation due to chronic liver failure associated with viral hepatitis (hepatitis C virus [HCV] or hepatitis B virus [HBV]). The patients were divided into three groups according to the drug treatments they received prior to the liver transplantation: Group A: lamivudine, Group B: adefovir, and Group C: interferon or interferon + ribavirin. Results: In the study population, 9 (20%) patients were females and 36 (80%) were males. The mean age was 45.7 (29–69) years. STAT-2, -3, and IL-6 expression were significantly higher in hepatocytes in Group A (p<0.05). Conclusion: High STAT-3, high IL-6, and low STAT-1 expression were associated with optimum hepatocyte regeneration and liver metabolic function. In this regard, lamivudine was the most effective drug in the present study.

Özet

Giriş: Viral hepatit infeksiyonlarına bağlı terminal dönem karaciğer hastalığı önemli bir sağlık sorunudur. Bu çalışmada antiviral tedavi almış terminal dönem karaciğer yetmezliği sebebiyle karaciğer nakli yapılan hepatektomi materyallerinde STAT-1,2,3,5,5a,5b, IL-6 ve IL-10 ekspresyonlarının karşılaştırılması amaçlandı. Yöntemler: viral hepatitler (HCV ve HBV)’e bağlı kronik karaciğer yetmezliği nedeni ile karaciğer transplantasyonu yapılan 45 olgu çalışmaya dâhil edildi. Çalışmamızda hastalar karaciğer transplantasyonu öncesi almış oldukları ilaç tedavilerine göre 3 gruba ayrıldı. Grup A: Lamuvidine, Grup B: Adefovir, Grup C: İnterferon veya interferon + ribavidin. Sonuçlar: Çalışma popülasyonunda 9 (%20) hasta kadındı ve 36 (%80) erkek idi. Yaş ortalaması 45.7 (29-69) idi. STAT-2, -3 ve IL-6 ekspresyonu Grup A'da hepatositlerde anlamlı olarak daha yüksekti (p <0.05). Sonuç: Yüksek STAT-3, yüksek IL-6 ve düşük STAT-1 ekspresyonu, optimumhepatositrejenerasyonu ve karaciğer metabolik fonksiyonu ile ilişkiliydi. Bu bağlamda, lamivudin, bu çalışmada en etkili ilaç olmuştur.

🔖

Cite This Article

TATLI, F., KIRIMLIOĞLU, S. H., YILMAZ, S., GÖZENELİ, O., KAYAALP, C., KARINCAOĞLU, M., DİRİCAN, A., BARUT, B., KIRIMLIOĞLU, V. (2018). Association of signal transducer and activator of transcription, interleukin-6, and interleukin-10 positivity with antiviral treatment in cirrhotic liver samples from patients with the hepatitis B or C virus. Dicle Tıp Dergisi, Cilt: 45 - Sayı: 2, 187–194. https://ajindex.com/articles/485050

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Henninghausen L, Robinson G.W. Interpretation of cytokine signaling through the transcription factors STAT 5A and STAT 5B. Genes Dev 2008; 22: 711-21.
  2. Yilmaz S, Kirimlioglu V, Kirimlioglu H et al. Effects of nucleoside analogues on liver regeneration 70% partially hepatectomized rats.Transplant Proc 2006; 38: 568-70.
  3. Moran DM, Mattocks MA, Cahill PA et al. Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway. Journal of Surgical Research 2008; 147: 23-33.
  4. Bautista D, Bermudez-Silva F.J, Lasarte J.J et al. Liver ekspression of proteins controlling interferon- mediated signaling as predictive factors in the response to therapy in patients with hepatitis C virus infection. Journal of Pathology 2007; 213: 347-55. Stärkel P, De Saeger C, Leclercq I et al. Role of signal transducer and activator of transcription 3 in liver fibrosis progression in chronic hepatitis C-infected patients. Laboratory investigation 2007; 87: 173–81
  5. Cui Y, Hosui A, Sun R et al. Loss of signal transducer and activator of transcription 5 leads to Hepatosteatosis and impaired liver regeneration. Hepatology 2007; 46: 504-13.
  6. Waris G, Sıddıqui A. Interaction between STAT-3 and HNF- 3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function. Journal of Virology 2002; 76: 2721-9.
  7. Siebler J, Protzer U, Wirtz S et al. Overexspression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication. European Journal of Gastroenterology & Hepatology 2006; 18: 167-74.
  8. Waris G, Sıddıqui A; J. Biosci. Regulatory mechanisms of viral hepatitis B and C. Journal of Biosciences 2003; 28: 311-21.
  9. Liaw YF, Kao JH, Piratvisuth T et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update. Hepatol Int. 2012 Jun;6: 531-61
  10. Huang R, Hao Y, Zhang J et al. Interferon alpha plus adefovir combination therapy versus interferon alpha monotherapy for chronic hepatitis B treatment: A meta analysis. Hepatol Res 2013; 43: 1040 51 Shi Y, Wu YH, Shu ZY et al. Interferon and lamivudine combination therapy versus lamivudine monotherapy for hepatitis B e antigen negative hepatitis B treatment: A meta analysis of randomized controlled trials. Hepatobiliary Pancreat Dis Int 2010; 9: 462 72. Lam YF, Yuen MF, Seto WK et al. Current antiviral therapy of chronic hepatitis B: Efficacy and safety. CurrHepat Rep 2011; 10: 235 43. Hynicka LM, Yunker N, Patel PH.A review of oral antiretroviral therapy