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Journals / Dicle Tıp Dergisi / 2022 / Cilt: 49 - Sayı: 2

In the differential diagnosis of sepsis and hemophagocytic lymphohistiocytosis, procalcitonin and C-reactive protein (CRP) may be as determinant as ferritin

Arzu OTO
Seher ERDOGAN
Sinan AKBAYRAM
Mehmet BOSNAK
Pages
297–307
Publication Date
2022-06-13
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

CRP and PCT levels were significantly lower (p: 0.007 and p

📌 3 Key Takeaways

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Objective & Hypothesis:Background: Hemophagocytic lymphohistiocytosis (HLH) and sepsis frequently appear as overlapping diagnoses in intensive care units.
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Key Findings & Data:Results: There were 16 patients in Group HLH and 15 in Group non-HLH.
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Conclusion & Impact:CRP and PCT levels were significantly lower (p: 0.007 and p
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:ferritin · Hemophagocytic lymphohistiocytosis · Children

Abstract

Background: Hemophagocytic lymphohistiocytosis (HLH) and sepsis frequently appear as overlapping diagnoses in intensive care units. It is necessary to distinguish HLH, which has a very high mortality, from sepsis. In this study, we wanted to draw attention to the potential of procalcitonin (PCT) and C-Reactive Protein (CRP) as a marker like ferritin in differential diagnosis. Thus, HLH can be diagnosed as early as possible and the necessary aggressive immunosuppressive therapy can be added to the existing treatment. Methods: All of the patients in the sepsis clinic who meet the HLH criteria Group HLH; patients not meeting the HLH criteria were defined as Group non-HLH. Files of all patients were reviewed in regard to HLH diagnosis criteria and H score. Results: There were 16 patients in Group HLH and 15 in Group non-HLH. CRP and PCT levels were significantly lower (p: 0.007 and p

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Cite This Article

OTO, A., ERDOGAN, S., AKBAYRAM, S., BOSNAK, M. (2022). In the differential diagnosis of sepsis and hemophagocytic lymphohistiocytosis, procalcitonin and C-reactive protein (CRP) may be as determinant as ferritin. Dicle Tıp Dergisi, Cilt: 49 - Sayı: 2, 297–307. https://ajindex.com/articles/484867

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