Journals / Çocuk Acil ve Yoğun Bakım Dergisi / 2020 / Cilt: 7 - Sayı: 2

Evaluation of the Incidence and Predictor Factors for Red Blood Cell Transfusion in the Mechanically Ventilated Children

Mekanik Ventilasyon Uygulanan Çocuklarda Eritrosit Transfüzyonu Sıklığı ve Belirleyici Etmenlerin Etmenlerin Değerlendirilmesi

Pages
74–80
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, patients who need transfusion should befollowed up more carefully and closely.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Transfusion of blood components, including redblood cells (RBC), platelets and plasma, is the fastest way to improvethe haematological state of critically ill patients and can be alifesaving intervention.
📊
Key Findings & Data:Therefore, we aimed to evaluate the incidence andpredictors of RBC transfusion in mechanically ventilated children.Methods: Data of patients admitted to PICUs from January 2014to April 2019 were extracted.
💡
Conclusion & Impact:Therefore, patients who need transfusion should befollowed up more carefully and closely.
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: Transfusion of blood components, including redblood cells (RBC), platelets and plasma, is the fastest way to improvethe haematological state of critically ill patients and can be alifesaving intervention. Although transfusion is a common practicein paediatric intensive care units (PICUs), its adverse effects are notclearly defined. Therefore, we aimed to evaluate the incidence andpredictors of RBC transfusion in mechanically ventilated children.Methods: Data of patients admitted to PICUs from January 2014to April 2019 were extracted. The mechanically ventilated patientswere categorised into two groups, and the relationship betweentransfusion and prognostic factors was examined.Results: This study investigated 373 children with a mean ageof 3.86±4.86 years. Among these children, 239 received RBCtransfusion (64.1%). Inotropic drug usage, acute kidney injury,continuous renal replacement therapy (CRRT), mortality, length ofmechanical ventilation, and duration of PICU stay were associatedwith RBC transfusion. Logistic regression analysis revealed thatinotropic drug usage increased the RBC transfusion requirement by5.168 fold, and CRRT increased it by 2.804 fold.Conclusion: Blood transfusion is an associated adversity in criticallyill children. Therefore, patients who need transfusion should befollowed up more carefully and closely.

Özet

Giriş: Eritrosit, trombosit ve plazma dahil olmak üzere kan bileşenlerinin transfüzyonu, kritik hastaların hematolojik durumunu iyileştirmenin en hızlı yoludur ve yaşam kurtarıcı bir girişim olabilir. Transfüzyon, çocuk yoğun bakım ünitelerinde (ÇYBÜ) yaygın bir uygulama olmasına rağmen, yan etkileri açıkça tanımlanmamıştır. Bu nedenle mekanik ventilasyon uygulanan çocuklarda eritrosit süspansiyonu transfüzyonu sıklığını ve belirleyici etmenlerini değerlendirmeyi amaçladık. Yöntemler: ÇYBÜ'ye Ocak 2014-Nisan 2019 tarihleri arasında başvuran hasta verileri toplandı. Mekanik ventilasyon uygulanan hastalar iki gruba ayrıldı ve transfüzyon ile prognostik faktörler arasındaki ilişki incelendi. Bulgular: Yaş ortalaması 3,86±4,86 yıl olan toplam 373 çocuk incelendi. Bu çocukların 239’u eritrosit süspansiyonu transfüzyonu aldı (%64,1). İnotropik ilaç kullanımı, akut böbrek hasarı, sürekli böbrek replasman tedavisi (SRRT), mortalite, mekanik ventilasyon süresi ve PYB'da kalma süresi, eritrosit süspansiyonu transfüzyonu ile ilişkilendirildi. Lojistik regresyon analizi, inotropik ilaç kullanımının eritrosit süspansiyonu transfüzyon gereksinimini 5.168 kat, SRRT kullanımını 2.804 kat arttırdığını göstermiştir. Sonuç: Kan transfüzyonu, kritik hasta çocuklarda daha kötü prognoz ile ilişkilidir. Bu nedenle transfüzyona ihtiyaç duyan hastaların daha dikkatli ve yakından takip edilmeleri gerektiği unutulmamalıdır.

🔖

Cite This Article

AYGÜN, F., DURAK, C., VAROL, F., ŞEN, H. S., PETMEZCİ, M. T., KAÇAR, A. (2022). Evaluation of the Incidence and Predictor Factors for Red Blood Cell Transfusion in the Mechanically Ventilated Children. Çocuk Acil ve Yoğun Bakım Dergisi, Cilt: 7 - Sayı: 2, 74–80. https://ajindex.com/articles/483781

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Armano R, Gauvin F, Ducruet T, Lacroix J. Determinants of red blood cell transfusions in a pediatric critical care unit: a prospective, descriptive epidemiological study. Crit Care Med. 2005;33:2637- 44
  2. Shander A. Anemia in the critically ill. Crit Care Clin. 2004;20:159-78
  3. Scharte M, Fink MP. Red blood cell physiology in critical illness. Crit Care Clin. 2003;31:651-7
  4. Bateman ST, Lacroix J, Boven K, Forbes P, Barton R, et al. Pediatric Acute Lung Injury and Sepsis Investigators Network: Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med. 2008;178:26-33
  5. Morris K. Revising the Declaration of Helsinki. Lancet. 2013;381:1889-90. 6. https://kalite.saglik.gov.tr/content/files/ duyurular_2011/2011/11_agustos_2011/prism.html
  6. Dirican A. Evaluation of the diagnostic tests performance and their comparisons. Cerrahpaşa J Med. 2001;32:25-30
  7. Bahadır E, Kalender B. Determination of Zung depression scale cutoff points using ROC Analysis. Adnan Menderes University. J Inst Soc Sci. 2018;5:137-47
  8. Hanley JA, McNeil BJ. The meaning and use of the area under a ROC curve. Radiology. 1982;143:27-36
  9. Kneyber MC, Hersi MI, Twisk JW, Markhorst DG, Plötz FB. Red blood cell transfusion in critically ill children is independently associated with increased mortality. Intensive Care Med. 2007;33:1414-22
  10. Zubrow ME, Thomas NJ, Friedman DF, Yehya N. RBC Transfusions Are Associated with Prolonged Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2018;19:88-96
  11. Akbaş T. Long length of stay in the ICU associates with a high erythrocyte transfusion rate in critically ill patients. J Int Med Res. 2019;47:1948-57
  12. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017;43:304-77
  13. De Zan F, Amigoni A, Pozzato R, Pettenazzo A, Murer L, et al. AKI Acute Kidney Injury in Critically Ill Children: A Retrospective Analysis of Risk Factors. Blood Purif. 2019;5:1-7
  14. Sık G, Demirbuga A, Günhar S, Nisli K, Citak A. Clinical Features and Indications Associated with Mortality in Continuous Renal Replacement Therapy for Pediatric Patients. Indian J Pediatr. 2019;86:360-4
  15. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, et al. The CRIT Study: anemia and blood transfusion in the critically ill-current