Journals / Çocuk Acil ve Yoğun Bakım Dergisi / 2021 / Cilt: 8 - Sayı: 3

Suicide as an Inflammatory Process: A CRP-based Case-control Study

Özkıyım Enflamatuvar Bir Süreç mi? CRP Temelli Bir Olgu-kontrol Çalışması

Pages
166–171
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The serum CRP levels of the control and suicide groups were 1.5±1.5 and 12.7±6.4 mg/L, respectively (p

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The number of suicide attempts and related deaths among adolescents is increasing every day.
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Key Findings & Data:Previous studies demonstrated the association between inflammation and psychiatric disease.
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Conclusion & Impact:The serum CRP levels of the control and suicide groups were 1.5±1.5 and 12.7±6.4 mg/L, respectively (p
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: The number of suicide attempts and related deaths among adolescents is increasing every day. Although suicide presents a problem for the general population, it is a more serious problem for those with psychiatric diseases. Previous studies demonstrated the association between inflammation and psychiatric disease. Thus, we aim to investigate the relationship between adolescent suicide attempts and the inflammatory biomarker C-reactive protein (CRP). Methods: This research was designed as a case-control study. The study population consisted of patients who been admitted to the pediatric emergency department between 01.03.2016 and 01.03.2019 following a suicide attempt. Healthy volunteers of similar age and gender characteristics who had been admitted to the pediatric clinic for routine examination were also recruited. The groups were compared in terms of demographic and clinical features and serum CRP levels. Results: A total of 239 patients (108 patients and 131 controls) were included in the study. No difference in terms of demographic data was noted between the groups. The serum CRP levels of the control and suicide groups were 1.5±1.5 and 12.7±6.4 mg/L, respectively (p

Özet

Giriş: Çocukluk çağı özkıyım girişimi sayısı ve buna bağlı ölümler gün geçtikçe artmaktadır. Bu durum tüm popülasyon için bir sorun teşkil etse de psikiyatrik hastalığa sahip olanlar için daha ciddi bir sorundur. Önceki çalışmalar enflamasyon ile psikiyatrik hastalık birlikteliğini göstermiştir. Biz de buradan yola çıkarak çocukluk çağı özkıyım girişimleri ile enflamatuvar bir biyomarker olan C-reaktif protein (CRP) ilişkisini araştırmayı planladık. Yöntemler: Çocuk acil servisine 01.03.2016-01.03.2019 tarihleri arasında özkıyım girişimi nedeniyle başvuran ve çalışmaya katılmayı kabul eden çalışma grubu ve sağlıklı gönüllü bireylerden oluşmuş kontrol grubu ile yapılan bu araştırma ileriye yönelik karakterde bir olgu-kontrol çalışması olarak dizayn edilmiştir. Her iki grubun demografik ve klinik verilerine ilaveten CRP düzeyleri incelenmiştir. Tüm bu parametreler açısından gruplar karşılaştırılmıştır. Bulgular: Çalışmaya 108 olgu, 131 kontrol olmak üzere toplam 239 olgu dahil edilmiştir. Gruplar arasında demografik veriler açısından fark tespit edilmemiştir. Serum CRP düzeyleri açısından gruplar değerlendirildiğinde kontrol grubunun ortalaması 1,5±1,5 mg/L olarak saptanırken, olgu gurubunun ortalaması 12,7±6,4 mg/L olarak bulunmuştur. (p

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Cite This Article

Gökalp, G., Berksoy, E., Anıl, M., Demir, Ş., Bardak, Ş., Demir, G. (2022). Suicide as an Inflammatory Process: A CRP-based Case-control Study. Çocuk Acil ve Yoğun Bakım Dergisi, Cilt: 8 - Sayı: 3, 166–171. https://ajindex.com/articles/483758

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References (16)

  1. World Health Organization Revised Global Burden of Disease(GBD)
  2. Available at: http://www.who.int/health info/global burden disease /2004reportupdateenindex.html 2. Kessler RC, Borges G, Walters EE. Prevalence of and risk factorsfor lifetime suicide attempts in the National Comorbidity Survey.Arch Gen Psychiatry. 1999
  3. Malone KM, Haas GL, Sweeney JA, Mann JJ. Major depression andthe risk of attempted suicide. J Affect Disord. 1995
  4. Kushner I. The phenomenon of the acute phase response. Ann N Y Acad Sci. 1982
  5. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999
  6. Gabay C, Smith MF, Eidlen D, Arend WP. Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein. J Clin Invest. 1997
  7. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003
  8. Malle E, De Beer FC. Human serum amyloid A (SAA) protein: a prominent acute-phase reactant for clinical practice. Eur J Clin Invest. 1996
  9. Prajitha N, Athira SS, Mohanan PV. Comprehensive biology of antipyretic pathways. Cytokine. 2019
  10. Goldbach JM, Roth J, Zeisberger E. Fever suppression by subdiaphragmatic vagotomy in guinea pigs depends on the route of pyrogen administration. Am J Physiol. 1997
  11. R675-81. 11. Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med. 1997
  12. Limanaqi F, Biagioni F, Gaglione A, Busceti CL, Fornai F. A Sentinel in the Crosstalk Between the Nervous andImmune System: The (Immuno)-Proteasome. Front. Immunol. 2019
  13. Bone RC. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do and do not know about cytokine regulation. Crit Care Med. 1996
  14. Nassberger L, Traskman-Bendz L. Increased soluble interleukin-2 receptor concentrations in suicide attempters. Acta Psychiatr Scand. 1993
  15. Lindqvist D, Janelidze S, Hagell P, Erhardt S, Samuelsson M, et al. Interleukin-6 is elevated in the cerebrospinal fluid of suicideattempters and related to symptom severity. Biol Psychiatry. 2009
  16. Tonelli LH, Stiller J, Rujescu D, Giegling I, Schneider B, et al. Elevated cytokine expression in the o