Journals / Çağdaş Cerrahi Dergisi / 2002 / Cilt: 16 - Sayı: 3

Primary hyperparathyroidism: still an underestimated disease in Turkey

Türkiye'de henüz yeterince dikkat çekmeyen bir hastalık: Primer hiperparatiroidi

Pages
137–143
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, primary hyperparathyroidism is still an underestimated disease in Turkey and patients are rarely asymptomatic due to delayed diagnosis. 94 % of the patients are successfully treated during the initial operation and 86 % after a reoperation.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study we aimed to evaluate the results of surgical treatment of 130 patients who were treated for primary hyperparathyroidism and followed up in our hospital between 1994-2002.
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Key Findings & Data:There were 116 women and 14 men with a mean age of 42.3 (18-72 years) and 45.6 (35-78 years) respectively.
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Conclusion & Impact:In conclusion, primary hyperparathyroidism is still an underestimated disease in Turkey and patients are rarely asymptomatic due to delayed diagnosis. 94 % of the patients are successfully treated during the initial operation and 86 % after a reoperation.
🔬Design:Research Article
📍Scope:2002 Verileri
⚙️Variables:Domain Parameters

Abstract

In this study we aimed to evaluate the results of surgical treatment of 130 patients who were treated for primary hyperparathyroidism and followed up in our hospital between 1994-2002. There were 116 women and 14 men with a mean age of 42.3 (18-72 years) and 45.6 (35-78 years) respectively. The mean f allow up time was 38 months. The mean period of time since onset of symptoms till diagnosis was 68 (3-120 months). Severe osteodystrophic changes were present in 80 % (104 patients). Only 3 % (4 patients) were asymptomatic. Preoperative localisation studies included ultrasound (US) Magnetic resonance imaging (MRI) and Tc-sesta MIBI 99m scintigram (Sg). An initial operation was performed in 116 patients, a second operation was performed in 21 patient and a third operation in one patient, so that a total of 138 operations were performed in 130 patients who had undergone 158 neck operations. Following initial, second and third operations 102 single adenoma, and 10 double adenoma were removed. In 18 patients subtotal parathyroidectomy was performed for primary hyperplasia. The incidence for persistent disase following initial operation was 6 % (7 patients) and for recurrent disase 2 % (2 patients). Operative success rate for the initial operation was 94 % and for the second operation 86 %. The morbidity and mortality rates were / % each. In conclusion, primary hyperparathyroidism is still an underestimated disease in Turkey and patients are rarely asymptomatic due to delayed diagnosis. 94 % of the patients are successfully treated during the initial operation and 86 % after a reoperation. Patients do feel better, but they are rarely free of symptoms.

Özet

Bu çalışmada primer hiperparatiroidi nedeni ile 1994-2002 yılları arasında hastanemizde tedavi ve takip edilen 130 hastanın cerrahi tedavi sonuçları irdelenmiştir. Olguların 116'sı kadın, 14'ü erkek idi ve ortalama yaş kadınlar için 42.3 (18-72), erkekler için 45.6 (35-78) bulundu. Ortalama takip süresi 38 ay dır. Semptomları ortaya çıkışı ile tanı arasında, geçen süre ortalama 68 aydır (3-120 ay). Ağır osteodistrofik değişiklikler % 80 hastada mevcut idi (104 hasta). Sadece % 3 hasta (4 hasta) asemptomatik idi. Preoperatif lokalizalisyon çalışmaları arasında ultrason (US), manyetik rezonans görüntüleme (MRI) ve Tc-sesta MIBI 99m sintigrafisine (Sg) yer verildi. Boyuna yönelik ilk cerrahi girişim 116 hastaya, ikinci cerrahi girişim 21 hastaya, üçüncü cerrahi girişim bir hastaya uygulandı. Toplam 138 cerrahi girişim 130 has-taya uygulanmış oldu ve bu hastaların anamnezlerinde toplam 158 cerrahi girşim bunııyordu. Birinci, ikinci ve üçüncü girişim ardından toplam 102 tek adenom, 10 çift adenom çıkartıldı. 18 hastada primer hipperplazi nedeni ile subtotal paratiroidektomi uygulandı, ilk cerrahi girişim ardından hastalığın devam etme oranı % 6 (7 hasta), nüks oranı % 2 (2 hasta) bulundu, ilk cerrahi girişim için başarı oranı % 94, ikinci cerrahi girişim için haşarı oranı % 86 bulundu. Mortalite ve morbidite oranları % l'dir. Sonuç olarak, yurdumuzda primer hiperparatiroidi henüz yeterince dikkat çekmeyen bir hastalık olup hastaların tanısı nadiren asemptomatik evrede konabilmektedir. Cerrahi başarı oranları ilk girşim için % 94, ikinci girşim için % 86'dır. Hastalar ameliyat sonrası kendilerini daha iyi hissetmekle birlikte, semptomlarından tamamen arınmaları nadirdir.

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Cite This Article

DÜREN, M., USLU, İ., TÜZÜN, Ş., GÜNDOĞDU, S., KADIOĞLU, P., HATEMİ, H., BÜKEY, Y., AÇBAY, Ö., ÖNSEL, Ç., DEVRANOĞLU, C. (2022). Primary hyperparathyroidism: still an underestimated disease in Turkey. Çağdaş Cerrahi Dergisi, Cilt: 16 - Sayı: 3, 137–143. https://ajindex.com/articles/482256

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