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Journals / Clinical and Experimental Health Sciences / 2021 / Cilt: 11 - Sayı: 2

Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats

Zuhal UÇKUN ŞAHİNOĞULLARI
Sevda GÜZEL
Necmiye CANACANKATAN
Cem YALAZA
Deniz KİBAR
Gulsen BAYRAK
Pages
191–198
Publication Date
2021-06-30
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: NAR has potential protective impact on liver injury caused by VCM, and the protective impacts of NAR at distinct doses may occur via different molecular mechanisms.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This investigation aimed to detect the possible protective impacts of naringenin (NAR) on vancomycin (VCM)-induced liver toxicity through measuring caspase-3, -8 and -9 activities as markers of apoptosis and the levels of tumor necrosis factor-alpha, cyclooxygenase-2 and vascular endothelial growth factor as inflammation markers and assessing the histopathological alterations in rats.
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Key Findings & Data:Methods: The rats were allocated into seven groups as, the control group (saline, intraperitoneally (i.p.)), VCM group (400 mg/kg/day, i.p.), Carboxymethyl cellulose group (0.5% CMC, orally), NAR100 group (100 mg/kg/day, orally), VCM+NAR25 group (25 mg/kg/day, orally), VCM+NAR50 group (50 mg/kg/day, orally), VCM+NAR100 group (100 mg/kg/day, orally).
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Conclusion & Impact:Conclusion: NAR has potential protective impact on liver injury caused by VCM, and the protective impacts of NAR at distinct doses may occur via different molecular mechanisms.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Vancomycin · Naringenin · Liver

Abstract

Objective: This investigation aimed to detect the possible protective impacts of naringenin (NAR) on vancomycin (VCM)-induced liver toxicity through measuring caspase-3, -8 and -9 activities as markers of apoptosis and the levels of tumor necrosis factor-alpha, cyclooxygenase-2 and vascular endothelial growth factor as inflammation markers and assessing the histopathological alterations in rats. Methods: The rats were allocated into seven groups as, the control group (saline, intraperitoneally (i.p.)), VCM group (400 mg/kg/day, i.p.), Carboxymethyl cellulose group (0.5% CMC, orally), NAR100 group (100 mg/kg/day, orally), VCM+NAR25 group (25 mg/kg/day, orally), VCM+NAR50 group (50 mg/kg/day, orally), VCM+NAR100 group (100 mg/kg/day, orally). The caspase enzyme activities and inflammation markers were measured using colorimetric methods and ELISA, respectively. Histopathological examinations were performed. Results: The caspase activities and levels of inflammation markers were significantly higher in the VCM group as opposed to the other groups. The caspase activities were significantly ameliorated in the VCM+NAR25 group compared to the VCM+NAR50 and VCM+NAR100 groups, but the levels of inflammation markers were significantly attenuated in VCM+NAR50 group and, especially, VCM+NAR100 group compared to VCM+NAR25 group. Conclusion: NAR has potential protective impact on liver injury caused by VCM, and the protective impacts of NAR at distinct doses may occur via different molecular mechanisms.

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Cite This Article

ŞAHİNOĞULLARI, Z. U., GÜZEL, S., CANACANKATAN, N., YALAZA, C., KİBAR, D., BAYRAK, G. (2021). Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats. Clinical and Experimental Health Sciences, Cilt: 11 - Sayı: 2, 191–198. https://ajindex.com/articles/481569

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