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Journals / Clinical and Experimental Health Sciences / 2022 / Cilt: 12 - Sayı: 1

The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats

Ayhan TANYELİ
Fazile Nur EKİNCİ AKDEMİR
Ersen ERASLAN
Mustafa Can GÜLER
Saime ÖZBEK ŞEBİN
Selim COMAKLI
İlhami GÜLÇİN
Pages
134–140
Publication Date
2022-03-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model.
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Key Findings & Data:Methods: CLP model was created for the rats in the CLP group. 20 mg/kg of Sinapic acid was given in the CLP-Sinapic acid group.
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Conclusion & Impact:Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Cecal ligation puncture · sinapic acid · lung

Abstract

Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model. Methods: CLP model was created for the rats in the CLP group. 20 mg/kg of Sinapic acid was given in the CLP-Sinapic acid group. At the end of the experiment, lung and kidney tissues were collected and biochemical analyzes were evaluated. Results: For the lung and kidney tissue samples; antioxidant levels decreased, and oxidant levels increased in the CLP group. When the immunohistochemical parameters were evaluated, IL-1β, caspase-3, and TNF-α immunopositivity were severe levels in CLP group. But immunopositivity of these parameters have been observed as attenuated in CLP-Sinapic acid group compared to CLP group. Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.

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Cite This Article

TANYELİ, A., AKDEMİR, F. N. E., ERASLAN, E., GÜLER, M. C., ŞEBİN, S. Ö., COMAKLI, S., GÜLÇİN, İ. (2022). The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. Clinical and Experimental Health Sciences, Cilt: 12 - Sayı: 1, 134–140. https://ajindex.com/articles/481165

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References (16)

  1. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. Chest. 1992;101(6):1644-55
  2. Newland A, Provan D, Myint S. Preventing severe infection after splenectomy. BMJ. 2005;331(7514):417-8
  3. Liu MW, Su MX, Wang YH, Wei W, Qin LF, Liu X, et al. Effect of melilotus extract on lung injury by upregulating the expression of cannabinoid CB2 receptors in septic rats. BMC Complement Altern Med. 2014;14:94
  4. Ritter C, Andrades M, Frota Junior ML, Bonatto F, Pinho RA, Polydoro M, et al. Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med. 2003;29(10):1782-9
  5. Bone RC. Gram-Negative Sepsis - Background, Clinical-Features, and Intervention. Chest. 1991;100(3):802-8
  6. Otero-Anton E, Gonzalez-Quintela A, Lopez-Soto A, Lopez-Ben S, Llovo J, Perez LF. Cecal ligation and puncture as a model of sepsis in the rat: Influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels. Eur Surg Res. 2001;33(2):77-9
  7. Gulcin I. Antioxidant and antiradical activities of L-carnitine. Life Sci. 2006;78(8):803-11
  8. Gulcin I. Antioxidant properties of resveratrol: A structure-activity insight. Innov Food Sci Emerg. 2010;11(1):210-8
  9. Abd El-Latif AA, Sayed AA, Soliman AM, Fahmy SR. Exploration of the therapeutic potential effect of Sepia officinalis in animal model of sepsis induced by cecal ligation and puncture. Injury. 2016;47(12):2709-17
  10. Gulcin I. Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). Toxicology. 2006;217(2-3):213-20
  11. Hoste E, Bagshaw S, Bellomo R, Cely C, Colman R, Cruz D, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intens Care Med. 2015;41(8):1411-23
  12. Zhai Y, Zhou X, Dai Q, Fan Y, Huang X. Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol. 2015;98(2):268-76
  13. Gulcin I. Antioxidant activity of food constituents: an overview. Arch Toxicol. 2012;86(3):345-91
  14. Gulcin I. Antioxidants and antioxidant methods: an updated overview. Arch Toxicol. 2020;94(3):651-715
  15. Ansari MA. Sinapic acid modulates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats. Biomed Pharmacother. 2017;93:646-53
  16. Ansari MA, Raish M, Ahmad A, Ahmad SF, Mudassar S, Mohsin K, et al