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Journals / Clinical and Experimental Health Sciences / 2022 / Cilt: 12 - Sayı: 3

The Effects of Therapeutic Intermittent Hypoxia Implementation on Complete Blood Count Parameters: An Experimental Animal Model

Talha KILIÇ
Mustafa SENGOR
Savaş ÜSTÜNOVA
Aysu KILIC
Hayrettin DAŞKAYA
Aysel Yıldız ÖZER
Pages
746–752
Publication Date
2022-09-28
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was determined that significant increase in MONO (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Intermittent hypoxia (IH) implementation is a method performed by intermittently decreasing oxygen concentration in inhaled air at specific rate.
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Key Findings & Data:In the study group, FiO2 level of inhaled air, was reduced to 10% in hypoxic cycle. 5 minutes normoxia-hypoxia cycle was used in each 30 minutes experiment period for study group.
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Conclusion & Impact:It was determined that significant increase in MONO (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Intermittent hypoxia · complete blood count tests · animal model

Abstract

Objective: Intermittent hypoxia (IH) implementation is a method performed by intermittently decreasing oxygen concentration in inhaled air at specific rate. This method varies between studies in terms of its application. This study aims to examine the changes in Complete Blood Count (CBC) parameters caused by IH implementation at therapeutic dose ranges with a single model. Methods: Ten Sprague Dawley type adult male rats were divided into two groups. In the study group, FiO2 level of inhaled air, was reduced to 10% in hypoxic cycle. 5 minutes normoxia-hypoxia cycle was used in each 30 minutes experiment period for study group. Control group remained in normoxic air for 30 minutes. 1 cc of blood was taken from mandibular vein from all rats at the end of 6th day. CBC analyzes were performed and differences between two groups were investigated. Results: Significant differences were detected in some CBC parameters between the two groups. It was determined that significant increase in MONO (p

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Cite This Article

KILIÇ, T., SENGOR, M., ÜSTÜNOVA, S., KILIC, A., DAŞKAYA, H., ÖZER, A. Y. (2022). The Effects of Therapeutic Intermittent Hypoxia Implementation on Complete Blood Count Parameters: An Experimental Animal Model. Clinical and Experimental Health Sciences, Cilt: 12 - Sayı: 3, 746–752. https://ajindex.com/articles/481091

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