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Journals / Cumhuriyet Science Journal / 2022 / Cilt: 43 - Sayı: 1

Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties

Murat DOĞAN
Duygu TAŞKIN
Mizgin ERMANOĞLU
Turan ARABACI
Pages
27–32
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the results, it was observed that the extract-loaded chitosan nanoparticles had a strong antiproliferative activity in both MCF 7 and HT29 cells.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, antioxidant and antiproliferative properties of ‘‘Achillea phrygia’’ were investigated.
📊
Key Findings & Data:Characterization of nanoparticles was made, antiproliferative activities and IC50 values of nanoparticles and only chloroform extract was calculated by cell culture studies and XTT cell viability test.
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Conclusion & Impact:According to the results, it was observed that the extract-loaded chitosan nanoparticles had a strong antiproliferative activity in both MCF 7 and HT29 cells.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, antioxidant and antiproliferative properties of ‘‘Achillea phrygia’’ were investigated. Since the antioxidant and antiproliferative activity of B sub-extract from plant’s chloroform extract is higher than other extracts, B sub-extract of Achillea phrygia was used in the preparation of nanoparticles. Characterization of nanoparticles was made, antiproliferative activities and IC50 values of nanoparticles and only chloroform extract was calculated by cell culture studies and XTT cell viability test. According to the results, it was observed that the extract-loaded chitosan nanoparticles had a strong antiproliferative activity in both MCF 7 and HT29 cells. The results of this study support that bioactive extract of the Achillea phrygia plant can be prepared as an herbal medicine candidate by preparing formulations with biopolymers and being investigated in cancer studies.

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Cite This Article

DOĞAN, M., TAŞKIN, D., ERMANOĞLU, M., ARABACI, T. (2022). Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties. Cumhuriyet Science Journal, Cilt: 43 - Sayı: 1, 27–32. https://ajindex.com/articles/477472

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References (12)

  1. Demirci B., Tabanca N., Wedge D.E., Khan S.I., Khan I.A., Aytac Z., Baser K.H.C., Chemical Composition and Biological Activities of Four Achillea Essential Oils from Turkey, Planta Medica, 75(4) (2009) 420-421
  2. Azaz A. D., Arabaci T., Sangun M. K., Essential Oil Composition and Antimicrobial Activities of Achillea biserrata M. Bieb. and Achillea salicifolia Besser subsp salicifolia Collected in Turkey, Asian Journal of Chemistry, 21(4) (2009) 3193-3198
  3. Chin Y., Chin W., Balunas M.J., Chai H.B., Kinghorn A.D. Drug discovery from natural sources, AAPS J., 8 (2006) E239–E253
  4. DeSantis C.E., Lin C.C., Mariotto A.B., Siegel R.L., Stein K.D., Kramer J.L., Cancer treatment and survivorship statistics, CA Cancer J. Clin., 64 (2014) 252–271
  5. Martinho N., Damgé C., Reis C.P., Recent advances in drug delivery systems, J. Biomater Nanobiotechnol., 2 (2011) 510-526
  6. Rodrigues T., Reker D., Schneider P., Schneider G. Counting on natural products for drug design, Nat. Chem., 8 (2016) 531-541
  7. Alfatemi S.M.H., Rad J.S., Rad M.S., Mohsenzadeh S., Teixeira da Silva J.A., Chemical composition, antioxidant activity and in vitro antibacterial activity of Achillea wilhelmsii C. Koch essential oil on methicillin-susceptible and methicillin-resistant Staphylococcus aureus spp., Biotech., 5(1) (2015) 39-44
  8. Akcin A., Akcin T.A., Seyis F., Coban A.Y., Durupinar B. Antimicrobial and Antioxidant Activity of the Essential Oil of the Turkish Endemic Species Achillea phrygia Boiss. & Bal., Journal of Essential Oil Bearing Plants, 17(2) (2014) 219-227
  9. Ghani A., Azizi M., Hassanzadeh-Khayyat M., Pahlavanpour A.A., Essential oil composition of Achillea eriophora, A. nobilis, A. biebersteinii and A. wilhelmsii from Iran, J. Essent. Oil Bear, Plants, 11 (5) (2008) 460–467
  10. Ghasemi Y., Khalaj A., Mohagheghzadeh A., Khosarav A., Composition and in vitro antimicrobial activity of the essential oil of Achillea eriophora, Chem. Nat. Comp., 44 (5) (2008) 663–665
  11. Kesdek M., Kordali S., Usanmaz A., Ercisli S., The toxicity of essential oils of some plant species against adults of colorado potato beetle, Leptinotarsa decemlineata Say (Coleoptera: Chrysomelidae), Comptes Rendus De L., Academie Bulgare Des Sciences, 68(1) (2015) 127-136
  12. Kocak A., Bagci E., & Bakoglu A. Chemical Composition of Essential Oils of Achillea teretifolia Willd. and A. millefolium L. subsp millefolium Growing in Turkey, Asian Journal of Chemistry, 22(5) (2010) 3653-3658. [