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Journals / Cumhuriyet Dental Journal / 2014 / Cilt: 17 - Sayı: 3

Comparative analysis of the potential effect of phase I therapy on gingival crevicular fluid myeloperoxidase levels in non-diabetic and diabetic patients with periodontitis

Hakan ÖZDEMİR
Hüseyin AYDIN
Nermin YAMALIK
Hakan DEVELİOĞLU
Kaya EREN
Pages
256–266
Publication Date
2022-10-11
DOI
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Results: Despite the relatively stable clinical measures and GCF MPO content in theperiodontally-healthy subjects, the clinical periodontal status improved, as significantreductions were observed in all of the clinical parameters in periodontitis patients with andwithout diabetes (p

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Objective & Hypothesis:Objectives: To evaluate the effect of periodontal therapy on clinical parameters as well as onmyeloperoxidase (MPO) activity in the gingival crevicular fluid (GCF) of patients with type 2diabetes mellitus and of systemically healthy individuals.
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Key Findings & Data:Materials and Methods: 24 type 2 DM patients subjects, and 21 systemically healthyindividuals, both groups with chronic periodontitis, and systemically and periodontally healthyindividuals were enrolled.
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Conclusion & Impact:Results: Despite the relatively stable clinical measures and GCF MPO content in theperiodontally-healthy subjects, the clinical periodontal status improved, as significantreductions were observed in all of the clinical parameters in periodontitis patients with andwithout diabetes (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To evaluate the effect of periodontal therapy on clinical parameters as well as onmyeloperoxidase (MPO) activity in the gingival crevicular fluid (GCF) of patients with type 2diabetes mellitus and of systemically healthy individuals. Materials and Methods: 24 type 2 DM patients subjects, and 21 systemically healthyindividuals, both groups with chronic periodontitis, and systemically and periodontally healthyindividuals were enrolled. Periodontal clinical parameters, namely periodontal probing depth(PD), plaque index (PI), gingival index (GI), clinical attachment level (CAL), and gingivalbleeding time index (GBI), as well as GCF MPO activity, were assessed before and 3 months afternon-surgical periodontal therapy. GCF enzyme activity was spectrophotometrically analyzed.Possible correlation between clinical periodontal status and MPO activity was also evaluated. Results: Despite the relatively stable clinical measures and GCF MPO content in theperiodontally-healthy subjects, the clinical periodontal status improved, as significantreductions were observed in all of the clinical parameters in periodontitis patients with andwithout diabetes (p

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Cite This Article

ÖZDEMİR, H., AYDIN, H., YAMALIK, N., DEVELİOĞLU, H., EREN, K. (2022). Comparative analysis of the potential effect of phase I therapy on gingival crevicular fluid myeloperoxidase levels in non-diabetic and diabetic patients with periodontitis. Cumhuriyet Dental Journal, Cilt: 17 - Sayı: 3, 256–266. https://ajindex.com/articles/477151

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References (15)

  1. Boutros SM. Michalowicz BS, Smith, QT, Aeppli DM. Crevicular fluid enzymes from endosseous dental implants and natural teeth. Int J Oral Maxillofac Implants 1996;11(3):322-330
  2. Cao F, Smith QT.Crevicular fluid myeloperoxidase at healthy and periodontitis sites. J Clin Periodontol 1989;16(1):17-20
  3. Cutler CW, Machen, RL, Jotwani R, Iacopino AM. Heightened gingival inflammation and attachment loss in type 2 diabetics with hiperlipidemia. J Periodontol 1999;70(11):1313- 1321
  4. Eiserich JP, Hristova M, Cross CE, Jones AD, Freeman BA, Hallival B, et al. Formation of nitric oxide- derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 1998;391(6665):393-397
  5. Eley BM, Cox SW. Advances in periodontal diagnosis.7. Proteolytic and hydrolytic enzymes link with periodontitis. Br Dent J 1998;184(7):323-328
  6. Figueredo CM, Gustaffson A.Protease activity in gingival crevicular fluid. Presence of free protease. J Clin Periodontol 1998;25(4):306-310
  7. Gursoy UK, Marakoglu I, Ersan S. Periodontal status and cytoplasmic enzyme activities in gingival crevicular fluid of type 2 diabetic and/or obese patients with chronic periodontitis. J Int Acad Periodontol 2006;8(1):2-5
  8. Gonçalves D, Correa FO, Khalil NM, de Faria Oliveira OM, Orrico SR.The effect of non-surgical periodontal therapy on peroxidase activity in diabetic patients: a case-control pilot study. J Clin Periodontol 2008;35:799-806
  9. Iacopino AM. Periodontitis and diabetes interrelationships: Role of inflammation. Ann Periodontol 2001;6(1):125-137
  10. Karjalainen KM, Knuuttila ML. The onset of diabetes and poor metabolic control increases gingival bleeding in children and adolescents with insulin- dependent diabetes mellitus. J Clin Periodontol 1996;23(12):1060-1067
  11. Kawamura M, Fukuda S, Kawabata K, Iwamoto Y. Comparison of health behaviour and oral/medical conditions in non-insulin-dependent (Type II) diabetics and non-diabetics. Aust Dent J 1998;43(5):315-320
  12. Kowolik MJ, Grant M. Myeloperoxidase activity in human gingival crevicular neutrophils. Arch Oral Biol 1983;28(4):293-295
  13. Lamster IB, Oshrain RL, Fiorello LA, Celenti RS, Gordon, JM. A comparison of 4 methods of data presentation for lysosomal enzyme activity in gingival crevicular fluid. J Clin Periodontol 1988;15(6):347-352
  14. Löe H, Sillness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-551
  15. Nishimura F, Takahashi K, Kurihara M, Takashiba S, Muray