Journals / Cerrahpaşa Medical Journal / 2020 / Cilt: 44 - Sayı: 2

Seizure Outcome in Adult Patients with Isolated Focal Cortical Dysplasia in Modern Era

Modern Çağda Yetişkin Fokal Kortikal Displazi Hastalarının Nöbet Sonlanımı

Pages
86–92
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Both type I (75%) and type II FCD (63.7%) showed higher seizure-free rate, and no significant difference was found (p=0.6).Conclusion: Surgery is safe and results in high seizure-free rate in adult patients with isolated FCD, but it is not enough because we cannot still explain why some patients continue to have seizure after complete removal of the dysplastic area.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Focal cortical dysplasia (FCD) is the most common cause of focal epilepsy in children and adults.
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Key Findings & Data:The aim of this retrospective study is to provide long-term seizure outcome in adults with isolated FCD.Methods: A total of 23 adult patients operated on type I and II FCD were included.
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Conclusion & Impact:Both type I (75%) and type II FCD (63.7%) showed higher seizure-free rate, and no significant difference was found (p=0.6).Conclusion: Surgery is safe and results in high seizure-free rate in adult patients with isolated FCD, but it is not enough because we cannot still explain why some patients continue to have seizure after complete removal of the dysplastic area.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Focal cortical dysplasia (FCD) is the most common cause of focal epilepsy in children and adults. The long-term seizure outcome has been reported in children, but very limited data are available for adults. The aim of this retrospective study is to provide long-term seizure outcome in adults with isolated FCD.Methods: A total of 23 adult patients operated on type I and II FCD were included. Medical history, seizure semiology, and radiological features were reviewed from the patients’ charts. Long-term seizure outcome was obtained with telephone interviews and last follow-up data available in archive.Results: At the last follow-up, 16 patients (69.6%) were totally seizure free even without aura and 7 patients (30.4%) continued to have seizure. Both type I (75%) and type II FCD (63.7%) showed higher seizure-free rate, and no significant difference was found (p=0.6).Conclusion: Surgery is safe and results in high seizure-free rate in adult patients with isolated FCD, but it is not enough because we cannot still explain why some patients continue to have seizure after complete removal of the dysplastic area.

Özet

Amaç: Fokal kortikal displazi (FKD) yetişkin ve çocuklardaki en sık görülen fokal epilepsi sebebidir. Uzun dönem nöbet akıbetleri çocuklarda raporlanmıştır ancak erişkin hastalar için etkin veriler oldukça sınırlıdır. Bu retrospektif çalışmadaki amaç erişkin izole FKD hastalarında uzun dönem nöbet sonuçlarının ortaya koyulmasıdır. Yöntem: Toplamda 23 tip-1 ve tip-2 FKD hastası opere edilmiştir. Hastaların tıbbi öyküsü, nöbet semiyolojisi ve radyolojik özellikleri incelendi. Uzun dönem nöbet durumları hakkında bilgiler, hastalarla yapılan telefon görüşmeleri ve güncel arşiv bilgilerinden edinildi. Bulgular: On altı hasta aurasız olarak tamamen nöbetsiz izlenmiştir, 7 hastanın nöbetleri devam etmektedir. Hem tip-1 hem de tip-2 FKD’de nöbetsizlik oranı daha yüksektir ve her ikisi arasında sonuçlarda anlamı fark bulunmamıştır. Sonuç: İzole FKD hastalarında cerrahi güvenlidir ve yüksek nöbetsizlik oranı ile sonuçlanmıştır; ancak bazı hastalarda displastik alanın tamamen çıkarılması sonrasında hastaların hala neden nöbet geçirdiklerini açıklayamamamız nedeniyle cerrahi tamamen yeterli değilir.

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Cite This Article

TAHMAZOĞLU, B., KARTUM, T. A., KEMERDERE, R., SAYYAHMELLI, S., TANRIVERDİ, T., YENİ, S. N. (2022). Seizure Outcome in Adult Patients with Isolated Focal Cortical Dysplasia in Modern Era. Cerrahpaşa Medical Journal, Cilt: 44 - Sayı: 2, 86–92. https://ajindex.com/articles/473164

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